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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">hepato</journal-id><journal-title-group><journal-title xml:lang="ru">Анналы хирургической гепатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5464</issn><issn pub-type="epub">2408-9524</issn><publisher><publisher-name>НЭИКОН ИСП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.16931/1995-5464.2016268-72</article-id><article-id custom-type="elpub" pub-id-type="custom">hepato-148</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПОДЖЕЛУДОЧНАЯ ЖЕЛЕЗА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PANCREAS</subject></subj-group></article-categories><title-group><article-title>ПАРАПАНКРЕАТИТ БЕЗ КТ-ПРИЗНАКОВ НЕКРОЗА ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ У БОЛЬНЫХ ОСТРЫМ ПАНКРЕАТИТОМ</article-title><trans-title-group xml:lang="en"><trans-title>PARAPANCREATITIS WITHOUT CT-SIGNS OF PANCREATIC NECROSIS IN PATIENTS WITH ACUTE PANCREATITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дюжева</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyuzheva</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дюжева Татьяна Геннадьевна — доктор мед. наук, профессор, заведующая отделом гепатопанкреатобилиарной и регенеративной хирургии НИИ молекулярной медицины </p><p>Для корреспонденции: Дюжева Татьяна Геннадьевна — 115432, Москва, ул. Сайкина, д. 21, кв. 42</p></bio><bio xml:lang="en"><p>Dyuzheva Tat’yana Gennad’evna — Doct. of Med. Sci., Professor, Head of the Department of Hepatopancreatobiliary and Regenerative Surgery, Research Institute of Molecular Medicine </p><p>For correspondence: Dyuzheva Tat’yana Gennad’evna — 42-21, Saikina str., Moscow, 115432, Russian Federation</p></bio><email xlink:type="simple">dtg679@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джус</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhus</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шефер</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shefer</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семененко</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Semenenko</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Платонова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Platonova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гальперин</surname><given-names>Э. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Galperin</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Городская клиническая больница им. С.С. Юдина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S.S. Yudin Municipal Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>22</day><month>02</month><year>2018</year></pub-date><volume>21</volume><issue>2</issue><fpage>68</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дюжева Т.Г., Джус Е.В., Шефер А.В., Семененко И.А., Платонова Л.В., Гальперин Э.И., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Дюжева Т.Г., Джус Е.В., Шефер А.В., Семененко И.А., Платонова Л.В., Гальперин Э.И.</copyright-holder><copyright-holder xml:lang="en">Dyuzheva T.G., Dzhus E.V., Shefer A.V., Semenenko I.A., Platonova L.V., Galperin E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hepato.elpub.ru/jour/article/view/148">https://hepato.elpub.ru/jour/article/view/148</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучить характер парапанкреатита и особенности течения заболевания у больных острым панкреатитом при отсутствии признаков некроза поджелудочной железы по данным компьютерной томографии (КТ).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведен анализ лечения 38 больных острым панкреатитом. При КТ с болюсным введением контрастного препарата признаков нарушения его накопления тканью поджелудочной железы не отмечено. Перипанкреатические изменения оценивали по негомогенным острым некротическим скоплениям и гомогенным острым перипанкреатическим жидкостным скоплениям. О распространенности парапанкреатита судили по классификациям Balthazar (2002) и K. Ishikawa и соавт. (2006).</p></sec><sec><title>Результаты</title><p>Результаты. Острые некротические скопления выявлены у 15 больных, индекс по Balthazar составил 3,7 ± 0,1, по K. Ishikawa — 2,46 ± 0,45 слева и 0,86 ± 0,4 справа (р &lt; 0,01). Консервативное лечение применили 7 (47%) больным. В 8 (53%) наблюдениях выполнены вмешательства: 3 больным — только чрескожные пункции, 5 больных после пункций были оперированы. Показанием к операции на 21-34-е сутки считали нарастание объема скоплений и инфицирование. Умер 1 больной. У пациентов, подвергнутых консервативному лечению, отмечена тенденция к меньшей выраженности парапанкреатита по градации японских авторов (2,0 ± 0,8) по сравнению с больными, которым выполняли пункции и операции (3,7 ± 1,5; р &gt; 0,5). По индексу Balthazar такой тенденции не было (3,4 ± 0,5 и 3,9 ± 0,4; р &gt; 0,05). Больные выписаны через 34 ± 5 дней. Острые перипанкреатические жидкостные скопления отмечены у 23 больных. Индекс по Balthazar составил 2,5 ± 0,2 балла, градация по японской классификации — 1,3 ± 0,2 слева, 0,8 ± 0,2 справа. Консервативное лечение проведено 22 (96%) больным, 1 пациенту выполнена чрескожная пункция. Все больные выписаны через 16 ± 1 день.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные результаты свидетельствуют о важности выявления острых некротических скоплений при отсутствии некроза в ПЖ в качестве маркера перипанкреатического некроза. В 33% подобных наблюдений требовались операции в связи с инфицированием. Классификация парапанкреатита по K. Ishikawa в большей степени отражает развитие парапанкреатита и его локализацию, чем индекс воспалительных изменений по Balthazar.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study the nature of peripancreatic lesions and its course in patients with AP without CT-signs of pancreatic necrosis.</p></sec><sec><title>Material and Methods</title><p>Material and Methods. We had analyzed the treatment of 38 patients with AP in whom contrast-enhanced CT did not reveal disorders of contrast accumulation by pancreatic tissue. Peripancreatic changes were assessed by presence of inhomogeneous acute necrotic collections and homogeneous acute peripancreatic fluid collections. Balthazar (2002) and K. Ishikawa et al. (2006) classification was used to estimate prevalence of parapancreatitis.</p></sec><sec><title>Results</title><p>Results. Acute necrotic collections were revealed in 15 patients. Balthazar index was 3.7 ± 0.1, K. Ishikawa index — 2.46 ± 0.45 on the left side and 0.86 ± 0.4 on the right side (p &lt; 0.01). 7 (47%) patients were treated conservatively.</p><p>8 (53%) patients were exposed to interventions including percutaneous punctures alone in 3 cases and 5 patients underwent surgery after puncture. The indication for surgery (in 21—34 days) was the increase of collections' volume and signs of infection. 1 patient died. Patients after conservative treatment had less severe parapancreatitis (2.0 ± 0.8) compared with patients who underwent puncture and surgery (3.7 ± 1.5, p &lt; 0.5) according to gradation of Japanese authors. There were no such differences in Balthazar index (3.4 ± 0.5 and 3.9 ± 0.4, p &gt; 0.05). Patients were discharged after 34 ± 5 days. Acute peripancreatic fluid collections were in 23 patients. Balthazar index was 2.5 ± 0.2, the gradation by Japanese classification — 1.3 ± 0.2 on the left side and 0.8 ± 0.2 on the right side. Conservative treatment was applied in 22 (96%) patients, 1 patient was exposed to percutaneous puncture. All patients were discharged after 16 ± 1 day.</p></sec><sec><title>Conclusion</title><p>Conclusion. Our data evidence the importance to identify acute necrotic collections in the absence of pancreatic necrosis as a marker of peripancreatic necrosis. 33% of these patients required surgery due to infection. Classification of parapancreatitis by Kazuo Ishikawa reflects parapancreatitis development and its localization more precisely than Balthazar index.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острый панкреатит</kwd><kwd>острое перипанкреатическое жидкостное скопление</kwd><kwd>острое некротическое скопление</kwd><kwd>компьютерная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute pancreatitis</kwd><kwd>acute peripancreatic fluid collection</kwd><kwd>acute necrotic collection</kwd><kwd>CT</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Thoeni R.F. The revised Atlanta Classification of acute pancreatitis: its importance for the radiologist and its effect on treatment. Radiology. 2013; 262 (3): 751-764. doi: 10.1148/radiol.11110947.</mixed-citation><mixed-citation xml:lang="en">Thoeni R.F. The revised Atlanta Classification of acute pancreatitis: its importance for the radiologist and its effect on treatment. Radiology. 2013; 262 (3): 751-764. doi: 10.1148/radiol.11110947.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Balthazar E.J., Robinson D.L., Megibow A.J., Ranson J.H. Acute pancreatitis: value of CT in establishing prognosis. Radiology. 1990; 174 (2): 331-336.</mixed-citation><mixed-citation xml:lang="en">Balthazar E.J., Robinson D.L., Megibow A.J., Ranson J.H. Acute pancreatitis: value of CT in establishing prognosis. Radiology. 1990; 174 (2): 331-336.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ishikawa K., Idoguchi K., Tanaka H., Tohma Y., Ukai I., Watanabe H., Matsuoka T., Yokota J., Sugimoto T. Classification of acute pancreatitis based on retroperitoneal extension: Application of the concept of interfascial planes. Eur. J. Radiol. 2006; 60 (3): 445-452.</mixed-citation><mixed-citation xml:lang="en">Ishikawa K., Idoguchi K., Tanaka H., Tohma Y., Ukai I., Watanabe H., Matsuoka T., Yokota J., Sugimoto T. Classification of acute pancreatitis based on retroperitoneal extension: Application of the concept of interfascial planes. Eur. J. Radiol. 2006; 60 (3): 445-452.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Banks P.A., Bollen T.L., Dervenis C., Gooszen H.G., Johnson C.D., Sarr M.G., Tsiotos G.G., Vege S.S. Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013; 62 (1): 102-111. doi: 10.1136/gutjnl-2012-302779.</mixed-citation><mixed-citation xml:lang="en">Banks P.A., Bollen T.L., Dervenis C., Gooszen H.G., Johnson C.D., Sarr M.G., Tsiotos G.G., Vege S.S. Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013; 62 (1): 102-111. doi: 10.1136/gutjnl-2012-302779.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bradley E.L. A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch. Surg. 1993; 128 (5): 586-590.</mixed-citation><mixed-citation xml:lang="en">Bradley E.L. A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch. Surg. 1993; 128 (5): 586-590.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">O'Connor O.J., McWilliams S., Maher M.M. Imaging of acute pancreatitis. AJR. 2011; 197 (2): W221-W225. doi: 10.2214/AJR.10.4338.</mixed-citation><mixed-citation xml:lang="en">O'Connor O.J., McWilliams S., Maher M.M. Imaging of acute pancreatitis. AJR. 2011; 197 (2): W221-W225. doi: 10.2214/AJR.10.4338.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Balthazar E.J. Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology. 2002; 223 (3): 603-613.</mixed-citation><mixed-citation xml:lang="en">Balthazar E.J. Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology. 2002; 223 (3): 603-613.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bruennler T., Hamer O.W., Lang S., Gruene S., Wrede C.E., Zorger N., Herold T., Siebig S., Rockmann F., Salzberger B., Feuerbach S., Schoelmerich J., Langgartner J. Outcome in a large unselected series of patients with acute pancreatitis. Hepatogastroenterology. 2009; 56 (91-92): 871-876.</mixed-citation><mixed-citation xml:lang="en">Bruennler T., Hamer O.W., Lang S., Gruene S., Wrede C.E., Zorger N., Herold T., Siebig S., Rockmann F., Salzberger B., Feuerbach S., Schoelmerich J., Langgartner J. Outcome in a large unselected series of patients with acute pancreatitis. Hepatogastroenterology. 2009; 56 (91-92): 871-876.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
