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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">hepato</journal-id><journal-title-group><journal-title xml:lang="ru">Анналы хирургической гепатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5464</issn><issn pub-type="epub">2408-9524</issn><publisher><publisher-name>НЭИКОН ИСП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.16931/1995-5464.2017245-53</article-id><article-id custom-type="elpub" pub-id-type="custom">hepato-20</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕЧЕНЬ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LIVER</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ ЭНДОСКОПИЧЕСКИХ ВМЕШАТЕЛЬСТВ У БОЛЬНЫХ ЦИРРОЗОМ ПЕЧЕНИ</article-title><trans-title-group xml:lang="en"><trans-title>THE EFFECTIVENESS OF ENDOSCOPIC INTERVENTIONS IN LIVER CIRRHOSIS PATIENTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Назыров</surname><given-names>Ф. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Nazyrov</surname><given-names>F. G.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Девятов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Devyatov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабаджанов</surname><given-names>А. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Babadzhanov</surname><given-names>A. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бабаджанов Азам Хасанович – доктор медицинских наук, старший научный сотрудник отделения хирургии портальной гипертензии и панкреатодуоденальной зоны </p><p>Для корреспонденции*: Бабаджанов Азам Хасанович – 100115, Ташкент, ул. Малая кольцевая (Фархадская), д. 10, АО “РСЦХ им. акад. В. Вахидова”. Тел.: 998-90-175-17-03. E-mail: azam746@mail.ru</p></bio><bio xml:lang="en"><p>Babadzhanov Azam Khasanovich – Doct. of Med. Sci., Senior Researcher of the Department of Portal Hypertension and Pancreatoduodenal Zone Surgery </p><p>For correspondence*: Babadzhanov Azam Khasanovich – 10, Farkhad str., Acad. V. Vahidov Republican Specialized Center of Surgery JSC, 100115, Tashkent, Uzbekistan. Phone: 998-90-175-17-03. E-mail: azam746@mail.ru</p></bio><email xlink:type="simple">azam746@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джуманиязов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhumaniyazov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Байбеков</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Baybekov</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>АО “Республиканский специализированный центр хирургии им. академика В. Вахидова”</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Vahidov Republican Specialized Center of Surgery</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>24</day><month>10</month><year>2017</year></pub-date><volume>22</volume><issue>2</issue><fpage>45</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Назыров Ф.Г., Девятов А.В., Бабаджанов А.Х., Джуманиязов Д.А., Байбеков Р.Р., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Назыров Ф.Г., Девятов А.В., Бабаджанов А.Х., Джуманиязов Д.А., Байбеков Р.Р.</copyright-holder><copyright-holder xml:lang="en">Nazyrov F.G., Devyatov A.V., Babadzhanov A.K., Dzhumaniyazov D.A., Baybekov R.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hepato.elpub.ru/jour/article/view/20">https://hepato.elpub.ru/jour/article/view/20</self-uri><abstract><sec><title>Цель</title><p>Цель. Проанализировать выживаемость больных циррозом печени и оценить эффективность эндоскопических вмешательств в профилактике кровотечений портального генеза.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Под наблюдением находились 449 больных с варикозным пищеводно-желудочным кровотечением, вызванным портальной гипертензией цирротического генеза, которые распределены на две группы. Основную группу составили 239 больных, пролеченных в 2010–2015 гг., контрольную – 210 пациентов (1996–2010 гг.).</p></sec><sec><title>Результаты</title><p>Результаты. Доля больных без рецидивов кровотечения из пищеводно-желудочных вариксов после эндоскопического гемостаза составила 27% (33 пациента) в контрольной группе и 54,2% (64) – в основной. При этапной тактике, включающей проведение портосистемного шунтирования после эндоскопического вмешательства, этот показатель оказался равным 32,4% (45) и 61,6% (109) соответственно группам. В отдаленном периоде после эндоскопических процедур рецидива кровотечения не отмечено в 40,7% (33 из 81) наблюдений в контрольной группе и в 68,1% (64 из 94) – в основной. При применении эндоскопического гемостаза вместе с шунтирующей операцией доля пациентов без рецидива составила 45,9% (45 из 98 больных) и 71,2% (102 из 153). В группе больных, получавших только медикаментозную терапию, лишь в 3 (10,7%) случаях удалось избежать рецидива кровотечения, что свидетельствует о ее низкой эффективности.</p></sec><sec><title> Заключение</title><p> Заключение. Современные возможности эндоскопических технологий позволили улучшить результаты лечения варикозных пищеводно-желудочных кровотечений. Этапное применение эндоскопических методов и портосистемных шунтирующих вмешательств позволяет улучшить показатели годовой выживаемости больных с 80 до 88% и трехгодичной – с 42 до 64%. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To analyze the survival of liver cirrhosis patients and to assess the effectiveness of endoscopic interventions to prevent bleedings of portal genesis.</p></sec><sec><title> Material and Мethods</title><p> Material and Мethods. The study included 449 liver cirrhotic patients with portal hypertension and bleeding from gastroesophageal varices. All patients were divided into 2 groups. The main group included 239 patients for the period 2010–2015 and the control group – 210 patients for the period 1996–2010.</p></sec><sec><title> Results</title><p> Results. There were 33 (27%) patients without recurrent variceal bleeding after endoscopic interventions in the control group and 64 (54.2%) patients in the main group. These values were 32.4% (45) and 109 (61.6%) respectively in case of staged approach including endoscopic hemostasis followed by portosystemic bypass. Long-term recurrence-free period was observed in 40.7% (33) cases of the control group and in 68.1% (64 of 94) cases of the main group after endoscopy. In case of endoscopic interventions followed by portosystemic bypass recurrence was absent in 45.9% (45 of 98 patients) and 71.2% (102 out of 153 patients) in both groups respectively. Conservative therapy alone was effective only in 3 (10.7%) cases to prevent recurrent bleeding that determines its low therapeutic ineffectiveness.</p></sec><sec><title>Conclusion</title><p>Conclusion. Modern possibilities of endoscopic technologies have significantly improved treatment and prevention of variceal bleeding. Staged application of endoscopy and portosystemic decompression improves 1-year survival from 80% to 88% and 3-year survival from 42% to 64%. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>цирроз печени</kwd><kwd>портальная гипертензия</kwd><kwd>варикозное пищеводно-желудочное кровотечение</kwd><kwd>портосистемное шунтирование</kwd><kwd>эндоскопическое лигирование</kwd><kwd>эндоскопическая склеротерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver cirrhosis</kwd><kwd>portal hypertension</kwd><kwd>gastroesophageal variceal bleeding</kwd><kwd>portosystemic bypass</kwd><kwd>endoscopic ligation</kwd><kwd>endoscopic sclerotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Figueiredo A., Romero-Bermejo F., Perdigoto R., Marcelino P. The end-organ impairment in liver cirrhosis: appointments for critical care. Crit. Care Res. Pract. 2012; 2012: 539412. 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