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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">hepato</journal-id><journal-title-group><journal-title xml:lang="ru">Анналы хирургической гепатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5464</issn><issn pub-type="epub">2408-9524</issn><publisher><publisher-name>НЭИКОН ИСП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.16931/1995-5464.201838-13</article-id><article-id custom-type="elpub" pub-id-type="custom">hepato-348</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПОДЖЕЛУДОЧНАЯ ЖЕЛЕЗА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PANCREAS</subject></subj-group></article-categories><title-group><article-title>Комбинированное хирургическое лечение больных раком головки поджелудочной железы</article-title><trans-title-group xml:lang="en"><trans-title>Combined surgical treatment of pancreatic head cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабунин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabunin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шабунин Алексей Васильевич – доктор мед. наук, профессор, член-корр. РАН, заведующий кафедрой хирургии Российской медицинской академии непрерывного профессионального образования, главный врач Городской клинической больницы им. С.П. Боткина. </p><p> </p></bio><bio xml:lang="en"><p>Alexey V. Shabunin – Doct. of Med. Sci., Professor, Corresponding-member of RAS, Head of the Chair of Surgery of Russian Medical Academy of Continuous Professional Education, Chief Physician of the Botkin Municipal Hospital. </p><p> 5, 2-nd Botkinsky pr., Moscow, 125284;  2/1, Barrikadnaya str., Moscow, 125993.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпов Алексей Андреевич – врач-хирург отделения хирургии печени и поджелудочной железы Городской клинической больницы им. С.П. Боткина. </p><p>125284, г. Москва, 2-й Боткинский пр-д, д. 5.</p></bio><bio xml:lang="en"><p>Alexey A. Karpov – Surgeon of the Department of Hepatopancreatobiliary Surgery of Botkin Municipal Hospital. </p><p>5, 2-nd Botkinsky pr., Moscow, 125284</p></bio><email xlink:type="simple">botkin.karpov@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кижаев</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kizhaev</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кижаев Евгений Васильевич – доктор мед. наук, профессор, заведующий кафедрой радиотерапии и радиологии Российской медицинской академии непрерывного профессионального образования. </p><p>125993, г. Москва, ул. Баррикадная, д. 2/1.</p></bio><bio xml:lang="en"><p>Evgeniy V. Kizhaev – Doct. of Med. Sci., Professor of the Chair of Radiotherapy and Radiology, Russian Medical Academy of Continuous Professional Education. </p><p>2/1, Barrikadnaya str., Moscow, 125993.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бедин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bedin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бедин Владимир Владимирович – канд. мед. наук, доцент кафедры хирургии Российской медицинской академии непрерывного профессионального образования, заместитель главного врача по хирургии Городской клинической больницы им. С.П. Боткина, г. Москва.</p><p>125284, г. Москва, 2-й Боткинский пр-д, д. 5; 125993, г. Москва, ул. Баррикадная, д. 2/1.</p></bio><bio xml:lang="en"><p>Vladimir V. Bedin – Cand. of Med. Sci., Associate Professor of the Chair of Surgery of Russian Medical Academy of Continuous Professional Education, Deputy Chief Physician for Surgical Care of Botkin Municipal Hospital.</p><p>5, 2-nd Botkinsky pr., Moscow, 125284;  2/1, Barrikadnaya str., Moscow, 125993.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тавобилов</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Tavobilov</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тавобилов Михаил Михайлович – канд. мед. наук, доцент кафедры хирургии Российской медицинской академии непрерывного профессионального образования, заведующий отделением хирургии печени и поджелудочной железы Городской клинической больницы им. С.П. Боткина, г. Москва.</p><p>125284, г. Москва, 2-й Боткинский пр-д, д. 5; 125993, г. Москва, ул. Баррикадная, д. 2/1.</p></bio><bio xml:lang="en"><p>Mikhail M. Tavobilov – Cand. of Med. Sci., Associate Professor of the Chair of Surgery of Russian Medical Academy of Continuous Professional Education, Head of the Department of Hepatopancreatobiliary Surgery of Botkin Municipal Hospital.</p><p>5, 2-nd Botkinsky pr., Moscow, 125284;  2/1, Barrikadnaya str., Moscow, 125993.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паклина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Paklina</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Паклина Оксана Владимировна – доктор мед. наук, профессор, заведующая патологоанатомическим отделением, Городская клиническая больница им. С.П. Боткина, Москва.</p><p>125284, г. Москва, 2-й Боткинский пр-д, д. 5.</p></bio><bio xml:lang="en"><p>Oksana V. Paklina – Doct. of Med. Sci., Professor, Head of the Pathology Department, Botkin Municipal Hospital.</p><p>5, 2-nd Botkinsky pr., Moscow, 125284.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сетдикова</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Setdikova</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сетдикова Галия Равилевна – канд. мед. наук, врач-патологоанатом патологоанатомического отделения, Городская клиническая больница им. С.П. Боткина, Москва.</p><p> 125284, г. Москва, 2-й Боткинский пр-д, д. 5.</p></bio><bio xml:lang="en"><p>Galiya R. Setdikova – Cand. of Med. Sci., Physician of the Pathology Department, Botkin Municipal Hospital. </p><p>5, 2-nd Botkinsky pr., Moscow, 125284.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Городская клиническая больница им. С.П. Боткина Департамента здравоохранения города Москвы;  Российская медицинская академия непрерывного профессионального образования Министерства здравоохранения Российской Федерации.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Botkin Municipal Hospital of Moscow Healthcare Department; Chair of Surgery and 3 Chair of Radiotherapy and Radiology, Russian Medical Academy of Continuous Professional Education of Healthcare Ministry of the Russian Federation.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Городская клиническая больница им. С.П. Боткина Департамента здравоохранения города Москвы.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Botkin Municipal Hospital of Moscow Healthcare Department.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования Министерства здравоохранения Российской Федерации.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2018</year></pub-date><volume>23</volume><issue>3</issue><fpage>8</fpage><lpage>13</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шабунин А.В., Карпов А.А., Кижаев Е.В., Бедин В.В., Тавобилов М.М., Паклина О.В., Сетдикова Г.Р., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Шабунин А.В., Карпов А.А., Кижаев Е.В., Бедин В.В., Тавобилов М.М., Паклина О.В., Сетдикова Г.Р.</copyright-holder><copyright-holder xml:lang="en">Shabunin A.A., Karpov A.A., Kizhaev E.V., Bedin V.V., Tavobilov M.M., Paklina O.V., Setdikova G.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hepato.elpub.ru/jour/article/view/348">https://hepato.elpub.ru/jour/article/view/348</self-uri><abstract><sec><title>Цель</title><p>Цель. Улучшить результаты лечения больных раком головки поджелудочной железы применением комбинированного хирургического способа лечения, включающего радикальную операцию и интраоперационную лучевую терапию.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведено проспективное клиническое исследование, в котором пациентам с протоковой аденокарциномой головки поджелудочной железы после резекционного этапа операции проводили интраоперационное лучевое воздействие на ложе удаленной опухоли.</p></sec><sec><title>Результаты</title><p>Результаты. С января 2013 по декабрь 2016 г. выполнено 63 радикальных оперативных вмешательства по поводу рака головки поджелудочной железы. В 31 наблюдении применили интраоперационную лучевую терапию. Анализировали показатели однолетней и трехлетней общей и безрецидивной выживаемости.</p></sec><sec><title>Заключение</title><p>Заключение. Хирургическое вмешательство, дополненное интраоперационной лучевой терапией, является безопасным и современным методом комбинированного лечения больных раком головки поджелудочной железы, позволяющим улучшить показатели выживаемости. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To improve the outcomes in patients with pancreatic head cancer using intraoperative radiotherapy (IORT).</p></sec><sec><title>Material and methods</title><p>Material and methods. Prospective trial included patients with ductal adenocarcinoma of the pancreatic head who underwent pancreatic surgery followed by IORT.</p></sec><sec><title>Results</title><p> Results. There were 63 patients with pancreatic ductal adenocarcinoma for the period from January 2013 till December 2016. IORT was applied in 31 cases. Annual, 3-year survival and disease-free survival were analyzed.</p></sec><sec><title>Conclusion</title><p>Conclusion. Surgery followed by IORT is safe and current approach for pancreatic head cancer.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>поджелудочная железа</kwd><kwd>рак</kwd><kwd>интраоперационная лучевая терапия</kwd><kwd>панкреатодуоденальная резекция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreas</kwd><kwd>cancer</kwd><kwd>intraoperative radiotherapy</kwd><kwd>pancreaticoduodenectomy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gong J., Gong J., Tuli R., Shinde A., Hendifar A.E. Metaanalyses of treatment standards for pancreatic cancer. Clin. Oncol. 2016; 4 (3): 315–325. DOI: 10.3892/mco.2015.716.</mixed-citation><mixed-citation xml:lang="en">Gong J., Gong J., Tuli R., Shinde A., Hendifar A.E. Metaanalyses of treatment standards for pancreatic cancer. Clin. Oncol. 2016; 4 (3): 315–325. DOI: 10.3892/mco.2015.716.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sinn M., Bahra M., Denecke T., Travis S., Pelzer U., Riess H. Perioperative treatment options in resectable pancreatic cancer – how to improve long-term survival. World J. Gastrointest. Oncol. 2016; 8 (3): 248–257. DOI: 10.4251/wjgo.v8.i3.248.</mixed-citation><mixed-citation xml:lang="en">Sinn M., Bahra M., Denecke T., Travis S., Pelzer U., Riess H. Perioperative treatment options in resectable pancreatic cancer –  how to improve long-term survival. World J. Gastrointest. Oncol. 2016; 8 (3): 248–257. DOI: 10.4251/wjgo.v8.i3.248.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ansari D., Gustafsson A., Andersson R. Update on the management of pancreatic cancer: surgery is not enough. World J. Gastroenterol. 2015; 21 (11): 3157–3165. DOI: 10.3748/wjg.v21.i11.3157.</mixed-citation><mixed-citation xml:lang="en">Ansari D., Gustafsson A., Andersson R. Update on the management of pancreatic cancer: surgery is not enough. World J. Gastroenterol. 2015; 21 (11): 3157–3165.  DOI: 10.3748/wjg.v21.i11.3157.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Li D., O’Reilly E.M. Adjuvant and neoadjuvant therapy for pancreatic cancer. Surg. Oncol. Clin. N. Am. 2016; 25 (2): 311– 326. DOI: 10.1016/j.soc.2015.11.010.</mixed-citation><mixed-citation xml:lang="en">Li D., O’Reilly E.M. Adjuvant and neoadjuvant therapy for pancreatic cancer. Surg. Oncol. Clin. N. Am. 2016; 25 (2): 311– 326. DOI: 10.1016/j.soc.2015.11.010.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kang M.J., Jang J.Y., Kim S.W. Surgical resection of pancreatic head cancer: What is the optimal extent of surgery. Cancer Lett. 2016; 382 (2): 259–265. DOI: 10.1016/j.canlet.2016.01.042.</mixed-citation><mixed-citation xml:lang="en">Kang M.J., Jang J.Y., Kim S.W. Surgical resection of pancreatic head cancer: What is the optimal extent of surgery. Cancer Lett. 2016; 382 (2): 259–265. DOI: 10.1016/j.canlet.2016.01.042.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Verbeke C.S. Resection margins and R1 rates in pancreatic cancer – are we there yet? Histopathology. 2008; 52: 787–796. DOI: 10.1111/j.1365-2559.2007.02935.x.</mixed-citation><mixed-citation xml:lang="en">Verbeke C.S. Resection margins and R1 rates in pancreatic cancer – are we there yet? Histopathology. 2008; 52: 787–796. DOI: 10.1111/j.1365-2559.2007.02935.x.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Verbeke C.S., Leitch D., Menon K.V., McMahon M.J., Guillou P.J., Anthoney A. Redefining the R1 resection in pancreatic cancer. Br. J. Surg. 2006; 93 (10): 1232–1237. DOI: 10.1002/bjs.5397.</mixed-citation><mixed-citation xml:lang="en">Verbeke C.S., Leitch D., Menon K.V., McMahon M.J., Guillou P.J., Anthoney A. Redefining the R1 resection in pancreatic cancer. Br. J. Surg. 2006; 93 (10): 1232–1237.  DOI: 10.1002/bjs.5397.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Esposito I., Kleeff I., Bergmann F., Reiser C., Herpel E., Friess H. Most pancreatic cancer resections are R1 resections. Ann. Surg. Oncol. 2008; 15 (6): 1651–1660. DOI: 10.1245/s10434-008-9839-8.</mixed-citation><mixed-citation xml:lang="en">Esposito I., Kleeff I., Bergmann F., Reiser C., Herpel E., Friess H. Most pancreatic cancer resections are R1 resections. Ann. Surg. Oncol. 2008; 15 (6): 1651–1660.  DOI: 10.1245/s10434-008-9839-8.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Calvo F., Sole C., Herranz R., Lopez-Bote M., Pascau J., Santos A., Muñoz-Calero A., Ferrer C., Garcia-Sabrido J.J. Intraoperative radiotherapy with electrons: fundamentals, results, and innovation. Ecancer medical science. 2013; 7: 339. DOI: 10.3332/ecancer.2013.339.</mixed-citation><mixed-citation xml:lang="en">Calvo F., Sole C., Herranz R., Lopez-Bote M., Pascau J., Santos A., Muñoz-Calero A., Ferrer C., Garcia-Sabrido J.J. Intraoperative radiotherapy with electrons: fundamentals, results, and innovation. Ecancer medical science. 2013; 7: 339. DOI: 10.3332/ecancer.2013.339.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Martínez-Noguera A., Montserrat E., García T., Larrosa R., Clotet M. Radiologic history exhibit. Cèsar Comas and Agustí Prió: pioneers and martyrs of Spanish radiology. Radiographics. 1996; 16 (5): 1215–1220. DOI: 10.1148/radiographics.16.5.8888401.</mixed-citation><mixed-citation xml:lang="en">Martínez-Noguera A., Montserrat E., García T., Larrosa R., Clotet M. Radiologic history exhibit. Cèsar Comas and Agustí Prió: pioneers and martyrs of Spanish radiology. Radiographics. 1996; 16 (5): 1215–1220. DOI: 10.1148/radiographics.16.5.8888401.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Abe M., Nishimura Y., Shibamoto Y. Intraoperative radiation therapy for gastric cancer. World J. Surg. 1995; 19 (4): 544–547. PMID: 7676698.</mixed-citation><mixed-citation xml:lang="en">Abe M., Nishimura Y., Shibamoto Y. Intraoperative radiation therapy for gastric cancer. World J. Surg. 1995; 19 (4): 544–547. PMID: 7676698.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Krengli F.M., Calvo M., Sole C.V., Fastner G., Alessandro M., Maluta S., Corvò R., Sperk E., Litoborski M., Pisani C., Fillini C., Fusconi F., Osti M.F., Tomio L., Marsiglia H., Ciabattoni A., Polkowski W., Grazia A.Di., Gava A., Kuten A., Iotti C., Gonzalez C., Sallabanda M., Dubois J.B., Catalano G., Valentini V. Clinical and technical characteristics of intraoperative radiotherapy. Analysis of the ISIORT-Europe database. Strahlenther Onkol. 2013; 189 (9): 729–737. DOI: 10.1007/s00066-013-0395-1.</mixed-citation><mixed-citation xml:lang="en">Krengli F.M., Calvo M., Sole C.V., Fastner G., Alessandro M., Maluta S., Corvò R., Sperk E., Litoborski M., Pisani C., Fillini C., Fusconi F., Osti M.F., Tomio L., Marsiglia H., Ciabattoni A., Polkowski W., Grazia A.Di., Gava A., Kuten A., Iotti C., Gonzalez C., Sallabanda M., Dubois J.B., Catalano G., Valentini V. Clinical and technical characteristics of intraoperative radiotherapy. Analysis of the ISIORT-Europe database. Strahlenther Onkol. 2013; 189 (9): 729–737.  DOI: 10.1007/s00066-013-0395-1.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
