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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">hepato</journal-id><journal-title-group><journal-title xml:lang="ru">Анналы хирургической гепатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5464</issn><issn pub-type="epub">2408-9524</issn><publisher><publisher-name>НЭИКОН ИСП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.16931/1995-5464.2018433-44</article-id><article-id custom-type="elpub" pub-id-type="custom">hepato-372</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВОЗМОЖНОСТИ РЕЗЕКЦИОННОЙ ХИРУРГИИ И ТРАНСПЛАНТАЦИИ ПЕЧЕНИ В ЛЕЧЕНИИ ОПУХОЛЕВЫХ И ПАРАЗИТАРНЫХ ЗАБОЛЕВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POSSIBILITIES OF RESECTION SURGERY AND LIVER TRANSPLANTATION FOR MALIGNANT AND PARASITIC DISEASES</subject></subj-group></article-categories><title-group><article-title>"Большие мелочи" обширных резекций печени при альвеококкозе</article-title><trans-title-group xml:lang="en"><trans-title>"Big trifles" of advanced liver resections for alveococcosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загайнов</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagaynov</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загайнов Владимир Евгеньевич - доктор медицинских наук, главный специалист по хирургии ФБУЗ ПОМЦ ФМБА России, заведующий кафедрой факультетской хирургии и трансплантологии ФГБОУ ВО ПИМУ МР.</p><p>603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1; 603109, Нижний Новгород, ул. Ильинская, д. 14</p></bio><bio xml:lang="en"><p>Vladimir E. Zagaynov — Doct. of Med. Sci., Chief Specialist for Surgery of Privolzhskiy Regional Medical Center of FMBA of Russia, Head of the Chair of Faculty-Based Surgery and Transplantology PRMU of MH RF.</p></bio><email xlink:type="simple">zagainov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9202-1321</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киселев</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiselev</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Киселев Николай Михайлович - ассистент кафедры факультетской хирургии и трансплантологии ФГБОУ ВО ПИМУ Минздрава России, врач-хирург онкологического отделения ФБУЗ ПОМЦ ФМБА России.</p><p>603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1; 603109, Нижний Новгород, ул. Ильинская, д. 14, тел.: +7-910-147-37-22</p><p>6113-0956</p></bio><bio xml:lang="en"><p>Nikolay M. Kiselev — Assistant of the Chair of Faculty-Based Surgery and Transplantology of Privolzhskiy Research Medical University of Ministry of Health of the Russian Federation, Oncologist of the Privolzhskiy Regional Medical Center of FMBA of Russia.</p><p>10/1, Minin and Pozharsky str., Nizhny Novgorod, 603005; 14, Ilinskaya str., Nizhny Novgorod, 603109</p></bio><email xlink:type="simple">kiselev_1989@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бельский</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belskiy</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бельский Владислав Александрович - главный специалист по анестезиологии-реаниматологии ФБУЗ ПОМЦ ФМБА России.</p><p>603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1</p></bio><bio xml:lang="en"><p>Vladislav A. Belskiy — Chief Specialist for Anesthesiology and Intensive Care, Privolzhskiy Regional Medical Center of FMBA of Russia.</p></bio><email xlink:type="simple">vlad.belsky@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыхтик</surname><given-names>П. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Rykhtik</surname><given-names>P. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рыхтик Павел Иванович — кандидат медицинских наук, главный специалист по лучевой диагностике ФБУЗ ПОМЦ ФМБА России</p><p>603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1</p></bio><bio xml:lang="en"><p>Pavel I. Rykhtik — Cand. of Med. Sci., Chief Specialist for Radiological Diagnosis, Privolzhskiy Regional Medical Center of FMBA of Russia.</p><p>10/1, Minin and Pozharsky str., Nizhny Novgorod, 603005</p></bio><email xlink:type="simple">rykhtik@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бобров</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bobrov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бобров Николай Викторович — ассистент кафедры факультетской хирургии и трансплантологии ФГБОУ ВО ПИМУ Минздрава России, врач-хирург онкологического отделения ФБУЗ ПОМЦ ФМБА России.</p><p>603005, Нижний Новгород, пл. Минина и Пожарского, д. 10/1; 603109, Нижний Новгород, ул. Ильинская, д. 14</p></bio><bio xml:lang="en"><p>Nikolay V. Bobrov — Assistant of the Chair of Faculty-Based Surgery and Transplantology of Privolzhskiy Research Medical University of Ministry of Health of the Russian Federation, Oncologist of the Privolzhskiy Regional Medical Center of FMBA of Russia.</p><p>10/1, Minin and Pozharsky str., Nizhny Novgorod, 603005; 14, Ilinskaya str., Nizhny Novgorod, 603109</p></bio><email xlink:type="simple">nikolay_bobrov15@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУВО “Приволжский исследовательский медицинский университет ” Министерства з дравоохранения Российской Федерации; ФБУЗ “Приволжский окружной медицинский центр” ФМБА России<country>Россия</country></aff><aff xml:lang="en">Privolzhskiy Research Medical University of Ministry of Health of the Russian Federation; Privolzhskiy Regional Medical Center of FMBA of Russia<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБОУВО “Приволжский исследовательский медицинский университет ” Министерства з дравоохранения Российской Федерации<country>Россия</country></aff><aff xml:lang="en">Privolzhskiy Research Medical University of Ministry of Health of the Russian Federation<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>13</day><month>01</month><year>2019</year></pub-date><volume>23</volume><issue>4</issue><fpage>33</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Загайнов В.Е., Киселев Н.М., Бельский В.А., Рыхтик П.И., Бобров Н.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Загайнов В.Е., Киселев Н.М., Бельский В.А., Рыхтик П.И., Бобров Н.В.</copyright-holder><copyright-holder xml:lang="en">Zagaynov V.E., Kiselev N.M., Belskiy V.A., Rykhtik P.I., Bobrov N.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hepato.elpub.ru/jour/article/view/372">https://hepato.elpub.ru/jour/article/view/372</self-uri><abstract><sec><title>Цель</title><p>Цель. Анализ технических приемов, применяемых при обширных резекциях печени с использованием трансплантационных технологий, непосредственно влияющих на результаты операции при распространенном альвеококкозе печени.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. С 2008 по 2018 г. лечение провели 65 пациентам с массивным осложненным альвекокко-зом печени. В 53 (82%) наблюдениях выполнена радикальная операция. Механическая желтуха отмечена у 45% пациентов, синдром портальной гипертензии — у 25%, паллиативные операции в анамнезе были у 58% больных. У 33 (50,8%) пациентов было распространенное паразитарное поражение с вовлечением афферентных и (или) эфферентных сосудов. Отдаленные метастазы выявлены у 6 больных: у 5 обнаружено метастатическое поражение легких, у 1 — поражение головного мозга и легких.</p></sec><sec><title>Результаты</title><p>Результаты. Выполнено 47 резекционных вмешательств R0 с применением трансплантационных технологий, из них 4 экстракорпоральных резекции и 6 трансплантаций печени. Реконструкция магистральных афферентных и эфферентных сосудов сопровождала 47% резекций печени: нижнюю полую вену реконструировали в 25 наблюдениях, воротную вену — также в 25. В 33 наблюдениях выполнена резекция внепеченочных желчных протоков. Осложнения в послеоперационном периоде развились у 26 пациентов: II по Clavien—Dindo — у 5, IIIb — у 13, IVb — у 2, V — у 6. Желчеистечение согласно ISGLS класса В выявлено у 6 больных, класса С — у 11. Заключение. Обширная резекция с применением трансплантационных технологий и трансплантация печени или ее фрагмента позволяют достичь радикального излечения 82% пациентов. Обширные операции оправданы при массивном альвеококкозе, поскольку позволяют добиться хороших отдаленных результатов. Для выполнения подобных вмешательств существует множество технических приемов, позволяющих избежать большинства досадных осложнений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. Analysis of the techniques of advanced liver resections involving transplantation technologies which affect the results of surgery for advanced liver alveococcosis.</p></sec><sec><title>Material and methods</title><p>Material and methods. There were 65 patients with massive complicated liver alveococcosis for the period from 2008 to 2018. Radical procedures were applied in 82% of cases (n = 53). Mechanical jaundice was observed in 45% of</p><p>patients, portal hypertension — in 25%. Previous palliative surgery was applied in 58% of patients. Thirty-three patients (50.8%) had advanced parasitic lesion with involvement of afferent and (or) efferent vascular structures. Distant metastases were detected in 6 patients: metastatic lung lesions occurred in 5 of them, simultaneous injury of brain and lungs — in 1 case.</p></sec><sec><title>Results</title><p>Results. There were 47 RO-resections with application of transplantation technologies including 4 extracorporeal resections and 6 orthotropic liver transplantations. Reconstruction of great afferent and efferent vascular structures was performed in 47% of cases: IVC repair — 25 cases, PV repair — 25 cases. Resection of extrahepatic bile ducts was made in 33 cases. Postoperative complications occurred in 26 cases: Clavien-Dindo type II — 5, IIIb — 13, IVb — 2, V — 6. Bile leakage ISGLS class B occurred in 6 cases, class C — in 11 cases.</p></sec><sec><title>Conclusion</title><p>Conclusion. Transplantation technologies for advanced liver resections and liver or its segment transplantation allow to achieve radical surgery in 82% of patients. Advanced operations are indicated for advanced liver alveococcosis due to good outcomes. There are various technical aspects of such operations which are useful to avoid most of complications.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>печень</kwd><kwd>желчные протоки</kwd><kwd>альвеококкоз</kwd><kwd>экстракорпоральная резекция</kwd><kwd>трансплантация</kwd><kwd>гепат-эктомия</kwd><kwd>противопаразитарная терапия</kwd><kwd>осложнения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver</kwd><kwd>bile ducts</kwd><kwd>alveococcosis</kwd><kwd>extracorporeal resection</kwd><kwd>transplantation</kwd><kwd>hepatectomy</kwd><kwd>antiparasitic therapy</kwd><kwd>complications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yong-de A., Wen-Jun Z., Ya-Min G., Xiu-Min H. Advances in surgical operation treatment of hepatic echinococcosis. 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