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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">hepato</journal-id><journal-title-group><journal-title xml:lang="ru">Анналы хирургической гепатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5464</issn><issn pub-type="epub">2408-9524</issn><publisher><publisher-name>НЭИКОН ИСП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.16931/1995-5464.2019210-24</article-id><article-id custom-type="elpub" pub-id-type="custom">hepato-505</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МИНИИНВАЗИВНЫЕ ТЕХНОЛОГИИ ПРИ МЕХАНИЧЕСКОЙ ЖЕЛТУХЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MINIMALLY INVASIVE TECHNOLOGIES FOR OBSTRUCTIVE JAUNDICE</subject></subj-group></article-categories><title-group><article-title>Дифференцированный подход к применению минимально инвазивных методов лечения опухолевой механической желтухи</article-title><trans-title-group xml:lang="en"><trans-title>Differentiated approach to the minimally invasive management of malignant obstructive jaundice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5088-5538</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гальперин</surname><given-names>Э. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Galperin</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гальперин Эдуард Израилевич – доктор мед. наук, профессор кафедры госпитальной хирургии ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет), Почетный президент Ассоциации гепатопанкреатобилиарных хирургов стран СНГ</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Eduard I. Galperin – Doct. of Sci. (Med.), Professor of the Chair of Hospital-Based Surgery, Sechenov First Moscow State Medical University (Sechenov University) </p><p>8, bld. 2, Trubetskaya str., Moscow, 119991 </p></bio><email xlink:type="simple">edgalp@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5011-4853</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахаладзе</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhaladze</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахаладзе Гурам Германович – доктор мед. наук, профессор, главный научный сотрудник научно-исследовательского отдела хирургии и хирургических технологий в онкологии ФГБУ РНЦРР Минздрава России </p><p>117997, Москва, ул. Профсоюзная, д. 86. Тел.: +7-903-590-06-86 </p></bio><bio xml:lang="en"><p>Guram G. Akhaladze – Doct. of Sci. (Med.), Professor, Chief Research Fellow of Scientific Department of Surgery and Surgical Technologies in Oncology, Russian Scientific Center of Roentgenoradiology </p><p>86, Profsoyusnaya str., Moscow, 117997</p><p>Phone: +7-903-590-06-86 </p></bio><email xlink:type="simple">gur371ax@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8489-2568</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ветшев</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vetshev</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ветшев Петр Сергеевич – доктор мед. наук, профессор, советник по клинической и научной работе ФГБУ “НМХЦ им. Н.И. Пирогова” Минздрава России, Заслуженный врач РФ, председатель координационного совета “Миниинвазивные технологии под контролем УЗИ и РТВ” Ассоциации гепатопанкреатобилиарных хирургов стран СНГ</p><p>105203, Москва, ул. Нижняя Первомайская, д. 70 </p></bio><bio xml:lang="en"><p>Peter S. Vetshev – Doct. of Sci. (Med.), Professor, Deputy Chief Executive Officer for Medical and Scientific Work of the Pirogov National Medical Surgical Center, Honored Doctor of the Russian Federation, Chairman of the Coordination Council “Minimally invasive technologies under ultrasound and X-ray assistance” of the Association of Hepatopancreatobiliary Surgeons of the CIS countries </p><p>70, str. Nizhnyaya Pervomayskaya, Moscow, 105203 </p></bio><email xlink:type="simple">p.vetshev@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0573-7573</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дюжева</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyuzheva</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дюжева Татьяна Геннадьевна – доктор мед. наук, профессор кафедры госпитальной хирургии ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)</p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Tatyana G. Dyuzheva – Doct. of Sci. (Med.), Professor of the Chair of Hospital-Based Surgery, Sechenov First Moscow State Medical University (Sechenov University) </p><p>8, bld. 2, Trubetskaya str., Moscow, 119991 </p></bio><email xlink:type="simple">dtg679@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра госпитальной хирургии лечебного факультета ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chair of Hospital-Based Surgery, Faculty of Medicine of the Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ “Национальный медико-хирургический центр им. Н.И. Пирогова” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov National Medical Surgical Center of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2019</year></pub-date><volume>24</volume><issue>2</issue><fpage>10</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гальперин Э.И., Ахаладзе Г.Г., Ветшев П.С., Дюжева Т.Г., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Гальперин Э.И., Ахаладзе Г.Г., Ветшев П.С., Дюжева Т.Г.</copyright-holder><copyright-holder xml:lang="en">Galperin E.I., Akhaladze G.G., Vetshev P.S., Dyuzheva T.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hepato.elpub.ru/jour/article/view/505">https://hepato.elpub.ru/jour/article/view/505</self-uri><abstract><p>Отношение к предоперационному билиарному дренированию (ПБД) при опухолевой механической желтухе за последнее время дважды менялось. Это обусловлено такими факторами, как осложнения минимально инвазивных методов ПБД, уровень блока желчных протоков, холангит, необходимость проведения неоадъювантной химиотерапии, срок до планируемой операции, тяжелое общее состояние больного, величина будущего остатка печени при планируемой резекции. В медицинских поисковых системах PubMed, MD Consult и National Library of Medicine изучили публикации по ключевым словам “механическая желтуха (МЖ)”, “клеточный иммунитет”, “предоперационное билиарное дренирование”, “селективное билиарное дренирование”, “дистальный и проксимальный блок желчных протоков”, “осложнения”. Ориентировались в основном на рандомизированные клинические исследования и метаанализы, мнения авторитетных специалистов в гепатопанкреатобилиарной хирургии, а также результаты собственных экспериментальных и клинических исследований. Анализ показал, что ПБД не является безопасной процедурой и его применение связано с увеличением числа осложнений. К абсолютным показаниям к ПБД следует отнести холангит, необходимость проведения неоадъювантной химиотерапии, повышенный риск радикальной операции и нерезектабельную опухоль. При уточнении показаний к ПБД при проксимальном блоке, вызванном воротной холангиокарциномой, следует ориентироваться на объем и функциональное состояние будущего остатка печени.</p></abstract><trans-abstract xml:lang="en"><p>Attitude towards preoperative biliary drainage for malignant obstructive jaundice have recently changed twice. This is due certain factors including complications of minimally invasive biliary drainage, level of bile duct block, cholangitis, need for neoadjuvant chemotherapy, time to scheduled surgery, severe general condition of patient, future liver remnant volume. We comprehensively searched PUBMED, MD Consult and National Library of Medicine using the following keywords: “obstructive jaundice (OJ)”, “cellular immunity”, “preoperative biliary drainage”, “selective biliary drainage”, “distal and proximal bile duct block”, “complications”. Randomized clinical trials and meta-analyzes, opinions of reputable specialists in hepatopancreatobiliary surgery and our own experimental and clinical studies were foreground. The analysis showed that preoperative biliary drainage is not a safe procedure and results an increased number of complications. Absolute indications for preoperative biliary drainage are cholangitis, need for neoadjuvant chemotherapy, increased risk of radical surgery and unresectable tumor. Future liver remnant volume should be considered in patients with portal cholangiocarcinoma followed by proximal block to determine indications for preoperative biliary drainage.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>печень</kwd><kwd>желчные протоки</kwd><kwd>механическая желтуха</kwd><kwd>миниинвазивные вмешательства</kwd><kwd>билиарное дренирование</kwd><kwd>холангит</kwd><kwd>холангиокарцинома</kwd><kwd>осложнения</kwd><kwd>резекция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver</kwd><kwd>bile ducts</kwd><kwd>obstructive jaundice</kwd><kwd>minimally invasive interventions</kwd><kwd>biliary drainage</kwd><kwd>cholangitis</kwd><kwd>cholangiocarcinoma</kwd><kwd>complications</kwd><kwd>resection</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wente M.N., Bassi C., Dervenis C., Gouma D.J., Izbicki J.R., Neoptolemos J.P., Padbury R.T., Sarr M.G., Traverso L.W., Yeo C.J., Büchler M.W. 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