<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">hepato</journal-id><journal-title-group><journal-title xml:lang="ru">Анналы хирургической гепатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5464</issn><issn pub-type="epub">2408-9524</issn><publisher><publisher-name>НЭИКОН ИСП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.16931/1995-5464.2019437-44</article-id><article-id custom-type="elpub" pub-id-type="custom">hepato-529</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОМПЛЕКСНОЕ ЛЕЧЕНИЕ МЕТАСТАЗОВ КОЛОРЕКТАЛЬНОГО РАКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COMPREHENSIVE TREATMENT OF COLORECTAL CANCER METASTASES</subject></subj-group></article-categories><title-group><article-title>Метастазы колоректального рака в печени, не контролируемые системной химиотерапией: роль внутриартериальной химиотерапии</article-title><trans-title-group xml:lang="en"><trans-title>Intraarterial chemotherapy in treatment of unresectable colorectal liver metastases refractory to systemic chemotherapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7683-5042</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поликарпов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Polikarpov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, врач отделения ангиографии, профессор кафедры радиологии и хирургических технологий 197758, Санкт-Петербург, поселок Песочный, ул. Ленинградская, д. 70, Российская Федерация </p><p>Тел.: 8-812-596-87-66Факс: 8-812-596-67-05 </p></bio><bio xml:lang="en"><p>Doct. of Sci. (Med.), Physician of the Department of Angiography, Professor</p><p>Phone: +7-812-596-87-66. Fax: +7-812-596-67-05 70, Leningradskaya str., Pesochny, 197758, S.-Petersburg, Russian Federation </p></bio><email xlink:type="simple">pol1110@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9190-116X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таразов</surname><given-names>П. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarazov</surname><given-names>P. G.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>70, Leningradskaya str., Pesochny, 197758, S.-Petersburg, Russian Federation</p></bio><email xlink:type="simple">tarazovp@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3323-7576</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кагачева</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kagacheva</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Врач хирург отделения ангиографии</p><p>197758, Санкт-Петербург, поселок Песочный, ул. Ленинградская, д. 70, Российская Федерация </p></bio><bio xml:lang="en"><p>70, Leningradskaya str., Pesochny, 197758, S.-Petersburg, Russian Federation</p></bio><email xlink:type="simple">tatiana.kagacheva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8415-946X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боровик</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Borovik</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>70, Leningradskaya str., Pesochny, 197758, S.-Petersburg, Russian Federation</p></bio><email xlink:type="simple">borovik1968@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6878-6762</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>70, Leningradskaya str., Pesochny, 197758, S.-Petersburg, Russian Federation</p></bio><email xlink:type="simple">av_kozlov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8746-8452</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гранов</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Granov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>член-корр. РАН, доктор мед. наук, профессор, научный руководитель </p><p>197758, Санкт-Петербург, поселок Песочный, ул. Ленинградская, д. 70, Российская Федерация </p></bio><bio xml:lang="en"><p>70, Leningradskaya str., Pesochny, 197758, S.-Petersburg, Russian Federation</p></bio><email xlink:type="simple">dmitriigranov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр радиологии и хирургических технологий им. акад. А.М. Гранова” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Granov Russian Scientific Centre of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>03</day><month>12</month><year>2019</year></pub-date><volume>24</volume><issue>4</issue><fpage>37</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Поликарпов А.А., Таразов П.Г., Кагачева Т.И., Боровик В.В., Козлов А.В., Гранов Д.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Поликарпов А.А., Таразов П.Г., Кагачева Т.И., Боровик В.В., Козлов А.В., Гранов Д.А.</copyright-holder><copyright-holder xml:lang="en">Polikarpov A.A., Tarazov P.G., Kagacheva T.I., Borovik V.V., Kozlov A.V., Granov D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hepato.elpub.ru/jour/article/view/529">https://hepato.elpub.ru/jour/article/view/529</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>печень</kwd><kwd>метастазы колоректального рака</kwd><kwd>внутриартериальная химиотерапия</kwd><kwd>химиоэмболизация</kwd><kwd>химиорезистентность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver</kwd><kwd>colorectal cancer metastases</kwd><kwd>intraarterial chemotherapy</kwd><kwd>chemoembolization</kwd><kwd>chemoresistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алиев В.А., Барсуков Ю.Ю., Николаев А.В. Колоректальный рак с синхронными отдаленными метастазами: обоснование циторедуктивных операций и перспектив – взгляд хирурга. Онкологическая колопроктология. 2012; 4: 15–20.</mixed-citation><mixed-citation xml:lang="en">Aliev V.A., Barsukov Y.Y., Nikolaev A.V. Colorectal cancer with synchronous distant metastases: rationale for cytoreductive surgery and its perspectives – a surgeon’s view. Oncological Coloproctology. 2012; 4: 15–20. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Горчаков С.В., Правосудов И.В., Васильев С.В., Олейник В.В., Оношко М.В., Попов Д.Е. Современные подходы к лечению больных колоректальным раком с метаста зами в печень. Вестник Санкт-Петербургского университета. Медицина. 2015; 3: 55–68.</mixed-citation><mixed-citation xml:lang="en">Gorchakov S.V., Pravosudov I.V., Vasil'ev S.V., Oleynic V.V., Onoshko M.V., Popov D.E. Modern approaches to treatment of colorectal cancer patients with liver metastases. Vestnik of Saint Petersburg University. Medicine. 2015; 3: 55–68. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). Московский научно-исследовательский онкологический институт имени П.А. Герцена. М., 2017. 250 c.</mixed-citation><mixed-citation xml:lang="en">Kaprin A.D., Starinskij V.V., Petrova G.V. Zlokachestvennye novoobrazovaniya v Rossii v 2015 godu (zabolevaemost' i smertnost') [Malignant neoplasms in Russia in 2015 (morbidity and mortality)]. Moscow Research Cancer Institute named after P.A. Herzen. Moscow, 2017. 250 p. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Трякин А.А., Артамонова Е.В., Болотина Л.В. Колоректальный рак. RUSSCO, 2016. С. 266–285.</mixed-citation><mixed-citation xml:lang="en">Tryakin A.A., Artamonova E.V., Bolotina L.V. Kolorektal'nyj rak [Practical recommendations for the treatment of malignant tumors of the Russian Society of Clinical Oncology]. RUSSCO, 2016. P. 266–285. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Adenis A., de la Fouchardiere C., Paule B., Burtin P., Tougeron D., Wallet J., Dourthe L.M., Etienne P.L., Mineur L., Clisant S., Phelip J.M., Kramar A., Andre T. Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program. BMC Cancer. 2016; 16 (7): 412–420. https://doi.org/10.1186/s12885-016-2440-9</mixed-citation><mixed-citation xml:lang="en">Adenis A., de la Fouchardiere C., Paule B., Burtin P., Tougeron D., Wallet J., Dourthe L.M., Etienne P.L., Mineur L., Clisant S., Phelip J.M., Kramar A., Andre T. Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: results from a multicenter study (REBECCA) nested within a compassionate use program. BMC Cancer. 2016; 16 (7): 412–420. https://doi.org/10.1186/s12885-016-2440-9</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ychou M., Viret F., Kramar A., Desseigne F., Mitry E., Guimbaud R., Delpero J.R., Rivoire M., Quénet F., Portier G., Nordlinger B. Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases. Cancer Chemother. Pharmacol. 2008; 62 (2): 195–201.</mixed-citation><mixed-citation xml:lang="en">Ychou M., Viret F., Kramar A., Desseigne F., Mitry E., Guimbaud R., Delpero J.R., Rivoire M., Quénet F., Portier G., Nordlinger B. Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases. Cancer Chemother. Pharmacol. 2008; 62 (2): 195–201.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Гранов А.М., Давыдов М.И. Интервенционная радиология в онкологии (пути развития и технологии). Под ред. Таразова П.Г., Гранова Д.А. 2-е изд., доп. СПб., 2013. 546 с.</mixed-citation><mixed-citation xml:lang="en">Granov A.M., Davydov M.I. Intervencionnaya radiologiya v onkologii (puti razvitiya i tekhnologii) [Interventional radiology in oncology (ways of development and technology)]. Tarazov P.G., Granov D.A., eds. 2nd ed., add. Saint Petersburg, 2013. 546 p. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bhutiani N., Martin R.C. Transarterial therapy for colorectal liver metastases. Surg. Clin. North. Am. 2016; 96 (2): 369–391. https://doi.org/10.1016/j.suc.2015.12.003</mixed-citation><mixed-citation xml:lang="en">Bhutiani N., Martin R.C. Transarterial therapy for colorectal liver metastases. Surg. Clin. North. Am. 2016; 96 (2): 369–391. https://doi.org/10.1016/j.suc.2015.12.003</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bhutiani N., Akinwande O., Martin R. Efficacy and toxicity of hepatic intra-arterial drug-eluting (Irinotecan) bead (DEBIRI) therapy in Irinotecan-refractory unresectable colorectal liver metastases. World J. Surg. 2016; 40 (5): 1178–1190. https://doi.org/10.1007/s00268-015-3386-9</mixed-citation><mixed-citation xml:lang="en">Bhutiani N., Akinwande O., Martin R. Efficacy and toxicity of hepatic intra-arterial drug-eluting (Irinotecan) bead (DEBIRI) therapy in Irinotecan-refractory unresectable colorectal liver metastases. World J. Surg. 2016; 40 (5): 1178–1190. https://doi.org/10.1007/s00268-015-3386-9</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Scevola G., Loreni G., Rastelli M., Sposato S., Ramponi S., Miele V. Third-line treatment of colorectal liver metastases using DEBIRI chemoembolization. Med. Oncol. 2017; 34 (3): 37–41. https://doi.org/10.1007/s12032-017-0890-9</mixed-citation><mixed-citation xml:lang="en">Scevola G., Loreni G., Rastelli M., Sposato S., Ramponi S., Miele V. Third-line treatment of colorectal liver metastases using DEBIRI chemoembolization. Med. Oncol. 2017; 34 (3): 37–41. https://doi.org/10.1007/s12032-017-0890-9</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Vogl T.J., Lahrsow M., Albrecht M.H., Hammerstingla R., Thompsonb Z.M., Gruber-Rouh T. Survival of patients with non-resectable, chemotherapy-resistant colorectal cancer liver metastases undergoing conventional lipiodol-based transarterial chemoembolization (cTACE) palliatively versus neoadjuvantly prior to percutaneous thermal ablation. Eur. J. Radiol. 2018; 102 (5): 138–145. https://doi.org/10.1016/j.ejrad.2018.03.015</mixed-citation><mixed-citation xml:lang="en">Vogl T.J., Lahrsow M., Albrecht M.H., Hammerstingla R., Thompsonb Z.M., Gruber-Rouh T. Survival of patients with non-resectable, chemotherapy-resistant colorectal cancer liver metastases undergoing conventional lipiodol-based transarterial chemoembolization (cTACE) palliatively versus neoadjuvantly prior to percutaneous thermal ablation. Eur. J. Radiol. 2018; 102 (5): 138–145. https://doi.org/10.1016/j.ejrad.2018.03.015</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Gennari L., Doci R., Bozzetti F., Veronesi U. Proposal for a clinical classification of liver metastases. Tumori. 1982; 68 (5): 443–449.</mixed-citation><mixed-citation xml:lang="en">Gennari L., Doci R., Bozzetti F., Veronesi U. Proposal for a clinical classification of liver metastases. Tumori. 1982; 68 (5): 443–449.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Konopke R., Roth J., Volk A., Pistorius S., Folprecht G., Zoephel K., Schuetze C., Laniado M., Saeger H., Kersting S. Colorectal liver metastases: an update on palliative treatment options. J. Gastrointest. Liver Dis. 2012; 21 (1): 83–91.</mixed-citation><mixed-citation xml:lang="en">Konopke R., Roth J., Volk A., Pistorius S., Folprecht G., Zoephel K., Schuetze C., Laniado M., Saeger H., Kersting S. Colorectal liver metastases: an update on palliative treatment options. J. Gastrointest. Liver Dis. 2012; 21 (1): 83–91.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Schiergens T.S., von Einem J., Thomas M.N. Multidisciplinary treatment of colorectal liver metastases. Minerva Med. 2017; 108 (6): 527–546. https://doi.org/10.23736/S0026-4806.17.05371-X</mixed-citation><mixed-citation xml:lang="en">Schiergens T.S., von Einem J., Thomas M.N. Multidisciplinary treatment of colorectal liver metastases. Minerva Med. 2017; 108 (6): 527–546. https://doi.org/10.23736/S0026-4806.17.05371-X</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fiorentini G., Aliberti C., Sarti D., Coschiera P., Tilli M., Mulazzani L., Giordani P., Graziano F., Gonzalez A.M., Marcos R.G., Mugnoz F.G., Cantore M., Ricci S., Catalano V., Mambrini A. Locoregional therapy and systemic cetuximab to treat colorectal liver metastases. World J. Gastrointest. Oncol. 2015; 15 (6): 47–54. https://doi.org/10.4251/wjgo.v7.i6.47</mixed-citation><mixed-citation xml:lang="en">Fiorentini G., Aliberti C., Sarti D., Coschiera P., Tilli M., Mulazzani L., Giordani P., Graziano F., Gonzalez A.M., Marcos R.G., Mugnoz F.G., Cantore M., Ricci S., Catalano V., Mambrini A. Locoregional therapy and systemic cetuximab to treat colorectal liver metastases. World J. Gastrointest. Oncol. 2015; 15 (6): 47–54. https://doi.org/10.4251/wjgo.v7.i6.47</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">van Hazel G., Pavlakis N., Goldstein D., Olver I.N., Tapner M.J., Price D., Bower G.D., Briggs G.M., Rossleigh M.A., Taylor D.J., George J. et al. Treatment of fluorouracil-refractory patients with liver metastases from colorectal cancer by using yttrium-90 resin microspheres plus concomitant systemic irinotecan chemotherapy. J. Clin. Oncol. 2009; 7 (25): 4089–4095. https://doi.org/10.1200/JCO.2008.20.8116</mixed-citation><mixed-citation xml:lang="en">van Hazel G., Pavlakis N., Goldstein D., Olver I.N., Tapner M.J., Price D., Bower G.D., Briggs G.M., Rossleigh M.A., Taylor D.J., George J. et al. Treatment of fluorouracil-refractory patients with liver metastases from colorectal cancer by using yttrium-90 resin microspheres plus concomitant systemic irinotecan chemotherapy. J. Clin. Oncol. 2009; 7 (25): 4089–4095. https://doi.org/10.1200/JCO.2008.20.8116</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cercek A., Boucher T., Gluskin J., Aguiló A., Chou J.F., Connell L.C., Capanu M., Reidy-Lagunes D., D'Angelica M., Kemeny N.E. Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies. J. Surg. Oncol. 2016; 114 (6): 655–663. https://doi.org/10.1002/jso.24399</mixed-citation><mixed-citation xml:lang="en">Cercek A., Boucher T., Gluskin J., Aguiló A., Chou J.F., Connell L.C., Capanu M., Reidy-Lagunes D., D'Angelica M., Kemeny N.E. Response rates of hepatic arterial infusion pump therapy in patients with metastatic colorectal cancer liver metastases refractory to all standard chemotherapies. J. Surg. Oncol. 2016; 114 (6): 655–663. https://doi.org/10.1002/jso.24399</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Arai Y., Aoyama T., Inaba Y., Okabe H., Ihaya T., Kichikawa K., Ohashi Y., Sakamoto J., Oba K., Saji S. Phase II study on hepatic arterial infusion chemotherapy using percutaneous catheter placement techniques for liver metastases from colorectal cancer (JFMC28 study). Asia Pac. J. Clin. Oncol. 2015; 11 (1): 41–48. https://doi.org/10.1111/ajco.12324</mixed-citation><mixed-citation xml:lang="en">Arai Y., Aoyama T., Inaba Y., Okabe H., Ihaya T., Kichikawa K., Ohashi Y., Sakamoto J., Oba K., Saji S. Phase II study on hepatic arterial infusion chemotherapy using percutaneous catheter placement techniques for liver metastases from colorectal cancer (JFMC28 study). Asia Pac. J. Clin. Oncol. 2015; 11 (1): 41–48. https://doi.org/10.1111/ajco.12324</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Massmann A., Rodt T., Marquardt S., Seidel R., Thomas K., Wacker F., Richter G.M., Kauczor H.U., Bücker A., Pereira P.L., Sommer C.M. Transarterial chemoembolization (TACE) for colorectal liver metastases – current status and critical review. Langenbeck’s Arch. Surg. 2015; 400 (6): 641–659. https://doi.org/10.1007/s00423-015-1308-9</mixed-citation><mixed-citation xml:lang="en">Massmann A., Rodt T., Marquardt S., Seidel R., Thomas K., Wacker F., Richter G.M., Kauczor H.U., Bücker A., Pereira P.L., Sommer C.M. Transarterial chemoembolization (TACE) for colorectal liver metastases – current status and critical review. Langenbeck’s Arch. Surg. 2015; 400 (6): 641–659. https://doi.org/10.1007/s00423-015-1308-9</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gruber-Rouh T., Naguib N., Eichler K., Naguib N.N., Beeres M., Langenbach M., Vogl T.J. Transarterial chemoembolization of unresectable systemic chemotherapy-refractory liver metastases from colorectal cancer: long-term results over a 10-year period. Int. J. Cancer. 2014; 134 (5): 1225–1231. https://doi.org/10.1159/000488644</mixed-citation><mixed-citation xml:lang="en">Gruber-Rouh T., Naguib N., Eichler K., Naguib N.N., Beeres M., Langenbach M., Vogl T.J. Transarterial chemoembolization of unresectable systemic chemotherapy-refractory liver metastases from colorectal cancer: long-term results over a 10-year period. Int. J. Cancer. 2014; 134 (5): 1225–1231. https://doi.org/10.1159/000488644</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Goi T., Naruse T., Kimura Y., Morikawa M., Koneri K., Yamaguchi A. Hepatic artery infusion therapy is effective for chemotherapy-resistant liver metastatic colorectal cancer. World J. Surg. Oncol. 2015; 13 (9): 296. https://doi.org/10.1186/s12957-015-0704-5</mixed-citation><mixed-citation xml:lang="en">Goi T., Naruse T., Kimura Y., Morikawa M., Koneri K., Yamaguchi A. Hepatic artery infusion therapy is effective for chemotherapy-resistant liver metastatic colorectal cancer. World J. Surg. Oncol. 2015; 13 (9): 296. https://doi.org/10.1186/s12957-015-0704-5</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Zervoudakis A., Boucher T., Kemeny N. Treatment options in colorectal liver metastases: hepatic arterial infusion. Visc. Med. 2017; 33 (1): 47–53. https://doi.org/10.1159/000454693</mixed-citation><mixed-citation xml:lang="en">Zervoudakis A., Boucher T., Kemeny N. Treatment options in colorectal liver metastases: hepatic arterial infusion. Visc. Med. 2017; 33 (1): 47–53. https://doi.org/10.1159/000454693</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
