hepatoАнналы хирургической гепатологииAnnaly khirurgicheskoy gepatologii = Annals of HPB Surgery1995-54642408-9524НЭИКОН ИСП10.16931/1995-5464.2019418-29hepato-540Research ArticleКОМПЛЕКСНОЕ ЛЕЧЕНИЕ МЕТАСТАЗОВ КОЛОРЕКТАЛЬНОГО РАКАCOMPREHENSIVE TREATMENT OF COLORECTAL CANCER METASTASESВозможности ПЭТ/КТ с 18F—ФДГ в дифференциальной диагностике метастазов колоректального рака в печень.Capabilities of 18F-FDG PET/CT in the differential diagnosis of colorectal liver metastaseshttps://orcid.org/0000-0003-2969-3480ТлостановаМ. С.TlostanovaM. S.

Cand. of Sci. (Med.), Deputy Chief Physician for Radiation Diagnostics, Radiologist, Leading Researcher, Department of Radiation Diagnostics 70, Leningradskaya str., Saint Petersburg, 197758, Russian Federation 

Phone: +7-911-970-49-22

tlostanovamarina@gmail.comhttps://orcid.org/0000-0002-6250-3223ДолбовА. Л.DolbovA. L.

врач-рентгенолог отделения радиоизотопной позитронно-эмиссионной томографии

ФГБУ “Российский научный центр радиологии и хирургических технологий им. акад. А.М. Гранова” Минздрава России

Radiologist at the Department of Positron Emission Tomography

70, Leningradskaya str., Saint Petersburg, 197758, Russian Federation

art.dolbov@yandex.ruhttps://orcid.org/0000-0002-1630-0564СтанжевскийАндрей АлексеевичStanzhevskiiA. A.

доктор мед. наук, заместитель директора по научной работе

ФГБУ “Российский научный центр радиологии и хирургических технологий им. акад. А.М. Гранова” Минздрава России

Doct. of Sci. (Med.), Deputy Director for Scientific Research

70, Leningradskaya str., Saint Petersburg, 197758, Russian Federation

stanzhevsky@gmail.comФГБУ “Российский научный центр радиологии и хирургических технологий им. акад. А.М. Гранова” Минздрава РоссииРоссияFSBI Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian FederationRussian FederationФГБУ "Российский научный центр радиологии и хирургических технологий" Министерства здравоохранения Российской ФедерацииРоссияFSBI Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian FederationRussian Federation2019031220192441829Copyright © Тлостанова М.С., Долбов А.Л., Станжевский А.А., 20192019Тлостанова М.С., Долбов А.Л., Станжевский А.А.Tlostanova M.S., Dolbov A.L., Stanzhevskii A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hepato.elpub.ru/jour/article/view/540

Цель—изучить возможности ПЭТ/КТ с 18F-ФДГ в дифференциальной диагностике метастазов КРР в печень.

Материал и методы

Материал и методы. Проведен ретроспективный анализ результатов лучевого обследования 126 больных колоректальным раком. Гистологический диагноз устанавливали на основании анализа морфологического материала из первичной опухоли. Природу очагов в печени подтверждали гистологическим исследованием или результатами лучевого обследования (динамического наблюдения). Чувствительность и специфичность метода определяли с помощью ROC-анализа c использованием показателя SUV в качестве числового классификатора.

Результаты

Результаты. У 51 (40,5%) пациента с колоректальным раком обнаружены метастазы в печень, у 25 (19,8%) – признаки внепеченочного распространения опухоли, у остальных 50 (39,7%) больных данных о прогрессировании заболевания не получено. Доброкачественные образования выявлены у 22 больных: у 10 они были обнаружены вместе с метастазами в печень, у 12 – без метастазов. Общее число выявленных в печени образований составило 166: 125 (75,3%) метастазов и 41 (24,7%) доброкачественное образование. По данным ROCанализа при SUV ≥ 3,0 чувствительность ПЭТ/КТ с 18F-ФДГ в диагностике метастазов в печени составила 84,8%, специфичность – 97,6%, площадь под ROC-кривой – 0,893 (95% ДИ 0,836–0,936, p < 0,0001), положительное прогностическое значение – 99,1%, отрицательное прогностическое значение – 67,8%. 

Заключение

Заключение. ПЭТ/КТ с <sup>18</sup>F-ФДГ является эффективной технологией лучевой дифференциальной диагностики новообразований печени более 10 мм у больных колоректальным раком. Применение количественной обработки данных с пороговым значением SUV ≥ 3,0 позволяет добиться высокой чувствительности и специфичности метода.

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The authors declare that there are no conflicts of interest present.