hepatoАнналы хирургической гепатологииAnnaly khirurgicheskoy gepatologii = Annals of HPB Surgery1995-54642408-9524НЭИКОН ИСП10.16931/1995-5464.2021125-33hepato-766Research ArticleПРЕДОПЕРАЦИОННОЕ ПЛАНИРОВАНИЕ - НЕИНВАЗИВНАЯ ЛУЧЕВАЯ ДИАГНОСТИКАPRE-OPERATIVE PLANNING – NON-INVASIVE RADIOLOGYВлияние параметров низкодозового протокола сканирования на результаты текстурного анализа протоковой аденокарциномы поджелудочной железыInfluence of the low-dose CE-MDCT scanning protocol parameters on the results of pancreatic ductal adenocarcinoma radiomic analysishttps://orcid.org/0000-0001-9782-7335ТихоноваВ. С.TikhonovaV. S.

Тихонова Валерия Сергеевна – аспирант отделения рентгенологии и магнитно-резонансных исследований 

117997, г. Москва, ул. Большая Серпуховская, д. 27

Valeriya S. Tikhonova – Graduate Student 

27, Bolshaya Serpukhovskaya str., Moscow, 117997

 

vdovenkobc28@mail.ruhttps://orcid.org/0000-0002-9357-0998КармазановскийГ. Г.KarmazanovskyG. G.

Кармазановский Григорий Григорьевич – доктор медицинских наук, профессор, член-корр. РАН, заведующий отделением рентгенологии и магнитно-резонансных исследований с кабинетом ультразвуковой диагностики ФГБУ “НМИЦ хирургии им. А.В. Вишневского”; профессор кафедры лучевой диагностики и терапии медико-биологического факультета ФГБОУ ВО “РНИМУ им. Н.И. Пирогова

117997, г. Москва, ул. Большая Серпуховская, д. 27;  117997, г. Москва, ул. Островитянова, д. 1

Grigory G. Kаrmаzаnovsky – Doct. of Sci. (Med.), Professor, Corresponding Member of the Russiаn Асаdemy of Sсienсes, Heаd of the Radiology Department of the Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of the Russian Federation; Professor of the Radiology Department of the Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation

27, Bolshaya Serpukhovskaya str., Moscow, 117997; 1, Ostrivityanova str., Moscow, 117997

karmazanovsky@ixv.ruhttps://orcid.org/0000-0001-7070-3391КондратьевЕ. В.KondratyevE. V.

Кондратьев Евгений Валерьевич – кандидат медицинских наук, старший научный сотрудник отделения рентгенологии и магнитно-резонансных исследований 

Тихонова Валерия Сергеевна – аспирант отделения рентгенологии и магнитно-резонансных исследований 

117997, г. Москва, ул. Большая Серпуховская, д. 27

Evgeny V. Kondratyev – Cand. of Sci. (Med.), Senior Researcher of Radiology Department

27, Bolshaya Serpukhovskaya str., Moscow, 117997

evgenykondratiev@gmail.comhttps://orcid.org/0000-0003-0781-9898ГруздевИ. С.GruzdevI. S.

Груздев Иван Сергеевич – аспирант отделения рентгенологии и магнитно-резонансных исследований

Тихонова Валерия Сергеевна – аспирант отделения рентгенологии и магнитно-резонансных исследований 

117997, г. Москва, ул. Большая Серпуховская, д. 27

Ivan S. Gruzdev – Graduate Student of Radiology Department

27, Bolshaya Serpukhovskaya str., Moscow, 117997

gruzdev_van@mail.ruhttps://orcid.org/0000-0002-6904-9318ГлотовА. В.GlotovA. V.

Глотов Андрей Вячеславович – врач-патологоанатом патологоанатомического отделения 

Тихонова Валерия Сергеевна – аспирант отделения рентгенологии и магнитно-резонансных исследований 

117997, г. Москва, ул. Большая Серпуховская, д. 27

Andrey V. Glotov – Pathologist of the Pathological Department

27, Bolshaya Serpukhovskaya str., Moscow, 117997

 

andrew.glotov@mail.ruФГБУ “Национальный медицинский исследовательский центр хирургии им. А.В. Вишневского” Минздрава РоссииРоссияVishnevsky National Medical Research Center of Surgery of the Ministry of Health of the Russian FederationRussian FederationФГБУ “Национальный медицинский исследовательский центр хирургии им. А.В. Вишневского” Минздрава России; ФГАОУ ВО “Российский национальный исследовательский медицинский университет им. Н.И. Пирогова” Минздрава РоссииРоссияVishnevsky National Medical Research Center of Surgery of the Ministry of Health of the Russian Federation; Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationRussian Federation2021200320212612533Copyright © Тихонова В.С., Кармазановский Г.Г., Кондратьев Е.В., Груздев И.С., Глотов А.В., 20212021Тихонова В.С., Кармазановский Г.Г., Кондратьев Е.В., Груздев И.С., Глотов А.В.Tikhonova V.S., Karmazanovsky G.G., Kondratyev E.V., Gruzdev I.S., Glotov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://hepato.elpub.ru/jour/article/view/766Цель

Цель. Изучение зависимости текстурных показателей при КТ протоковой аденокарциномы поджелудочной железы от применения стандартных и низкодозовых параметров сканирования.

Материал и методы

Материал и методы. В исследование включено 52 пациента с гистологически подтвержденной неметастатической местнораспространенной протоковой аденокарциномой поджелудочной железы, которым выполняли КТ с использованием стандартных (120 кВ) и низкодозовых (100 кВ) протоколов сканирования. Сравнивали текстурные показатели гистологически идентичных опухолей во все фазы сканирования.

Результаты

Результаты. Получено 53 текстурных показателя для всех типов дифференцировки протоковой аденокарциномы поджелудочной железы в каждую фазу сканирования. Из 53 показателей текстурного анализа менее половины статистически различались для каждой фазы сканирования – 11 (20,8%) показателей для нативной фазы, 18 (34%) – для артериальной, 19 (35,8%) – для венозной и отсроченной фаз сканирования при всех типах дифференцировки опухоли (GLCM_Contrast, GLCM_Correlation, GLCM_Dissimilarity, GLRLM_ SRHGE и пр., р < 0,05). Диагностическая точность >50% показателей сохраняется при изменении напряжения на трубке в протоколе КТ.

Заключение

Заключение. Применение низкодозового протокола КТ не влияет на диагностическую точность показателей текстурного анализа в предоперационной оценке степени дифференцировки протоковой аденокарциномы поджелудочной железы.

To investigate the dependence of textural parameters of pancreatic ductal adenocarcinoma on using standard and low-dose CT protocols.

Materials and methods

Materials and methods. The study included 52 consecutive patients with histologically confirmed pancreatic ductal 

adenocarcinoma who underwent contrast enhanced computed tomography using standard (120 kV) and low-dose (100 kV) scanning protocols. We compared radiomics features of the identical histological tumors in all scanning phases.

Results

Results. We calculated 53 radiomics features in all types of pancreatic ductal adenocarcinoma grade differentiation for all scanning phases. We identified that out of 53 features of texture analysis, less than half was statistically different for each scan phase (11 parameters (20.8%) for the unenhanced phase; 18 parameters (34%) for the arterial; 19 parameters (35.8%) for the venous and delayed scanning phases), in all types of tumor differentiation (GLCM_ Contrast, GLCM_Correlation, GLCM_Dissimilarity, GLRLM_SRHGE etc., p < 0.05).The diagnostic accuracy of more than 50% of the radiomics features is preserved when changing kV in the CT scan protocol.

Conclusion

Conclusion. The use of a low-dose CT protocol doesn’t affect the diagnostic accuracy of the features of texture analysis in the preoperative assessment of the degree of differentiation of pancreatic ductal adenocarcinoma.

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The authors declare that there are no conflicts of interest present.