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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">hepato</journal-id><journal-title-group><journal-title xml:lang="ru">Анналы хирургической гепатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5464</issn><issn pub-type="epub">2408-9524</issn><publisher><publisher-name>НЭИКОН ИСП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.16931/1995-5464.2022-2-13-19</article-id><article-id custom-type="elpub" pub-id-type="custom">hepato-894</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СОВРЕМЕННЫЕ ПОДХОДЫ В ДИАГНОСТИКЕ И ЛЕЧЕНИИ ПОРТАЛЬНОЙ ГИПЕРТЕНЗИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MODERN APPROACHES IN THE DIAGNOSIS AND TREATMENT OF PORTAL HYPERTENSION</subject></subj-group></article-categories><title-group><article-title>Обоснование необходимости симультанного применения трансъюгулярного внутрипеченочного портосистемного шунтирования и частичной эмболизации селезенки у больных портальной гипертензией на фоне цирроза печени</article-title><trans-title-group xml:lang="en"><trans-title>Justification for the necessity of simultaneously performing transjugular intrahepatic portosystemic shunt placement and partial splenic embolizationin patients with portal hypertension in the setting of liver cirrhosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0522-0681</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабунин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabunin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шабунин Алексей Васильевич – доктор мед. наук, профессор, член-корр. РАН, заведующий кафедрой хирургии ФГБОУ ДПО РМАНПО Минздрава России, главный врач</p><p>125284, Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Alexey V. Shabunin – Doct. of Sci. (Med.), Professor, Corresponding Member of RAS, Head of Surgical Department, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation; Chief Doctor</p><p>5, 2nd Botkinsky proezd, Moscow, 125284</p></bio><email xlink:type="simple">shabunin-botkin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8441-6561</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бедин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bedin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бедин Владимир Владимирович – доктор мед. наук, доцент кафедры хирургии ФГБОУ ДПО РМАНПО Минздрава России, заместитель главного врача</p><p>125284, Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Vladimir V. Bedin – Doct. of Sci. (Med.), Associated Professor at the Surgical Department, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation; Deputy Chief Doctor</p><p>5, 2nd Botkinsky proezd, Moscow, 125284</p></bio><email xlink:type="simple">bedinvv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8016-1610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дроздов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Drozdov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дроздов Павел Алексеевич – канд. мед. наук, заведующий отделением трансплантации органов и(или) тканей человека</p><p>125284, Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Pavel A. Drozdov – Cand. of Sci. (Med.), Head of Department of Human Organ and(or) Tissue Transplantation</p><p>5, 2nd Botkinsky proezd, Moscow, 125284</p></bio><email xlink:type="simple">dc.drozdov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5814-4504</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левина</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Levina</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Левина Оксана Николаевна – канд. мед. наук, заведующая отделением гастрогепатопанкреатоэнтерологии</p><p>125284, Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Oxana N. Levina – Cand. of Sci. (Med.), Head of Department of Gastroenterohepatology</p><p>5, 2nd Botkinsky proezd, Moscow, 125284</p></bio><email xlink:type="simple">levinaoks@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5176-9061</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цуркан</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsurkan</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цуркан Владимир Андреевич – врач-интервенционный радиолог</p><p>125284, Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Vladimir A. Tsurkan – Interventional Radiologist</p><p>5, 2nd Botkinsky proezd, Moscow, 125284</p></bio><email xlink:type="simple">tsurkan_v@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8225-0024</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Журавель</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhuravel</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Журавель Олеся Сергеевна – врач-хирург</p><p>125284, Москва, 2-й Боткинский проезд, д. 5</p></bio><bio xml:lang="en"><p>Olesya S. Zhuravel – Surgeon; Senior Assistant, Surgical Department, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation</p><p>5, 2nd Botkinsky proezd, Moscow, 125284</p></bio><email xlink:type="simple">olesyazhu@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ “Городская клиническая больница им. С.П. Боткина ДЗМ”</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S.P. Botkin City Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>07</day><month>06</month><year>2022</year></pub-date><volume>27</volume><issue>2</issue><fpage>13</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шабунин А.В., Бедин В.В., Дроздов П.А., Левина О.Н., Цуркан В.А., Журавель О.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Шабунин А.В., Бедин В.В., Дроздов П.А., Левина О.Н., Цуркан В.А., Журавель О.С.</copyright-holder><copyright-holder xml:lang="en">Shabunin A.V., Bedin V.V., Drozdov P.A., Levina O.N., Tsurkan V.A., Zhuravel O.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hepato.elpub.ru/jour/article/view/894">https://hepato.elpub.ru/jour/article/view/894</self-uri><abstract><sec><title>Цель</title><p>Цель. Улучшить результаты лечения больных с различными проявлениями портальной гипертензии симультанным выполнением трансъюгулярного внутрипеченочного портосистемного шунтирования (TIPS) и частичной эмболизации селезенки.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. На первом этапе исследования выполнили ретроспективный анализ частоты проявлений портальной гипертензии у 100 последовательных больных циррозом печени. На втором этапе в группе из 20 больных с варикозным расширением вен пищевода и (или) желудка и гиперспленизмом оценили безопасность и эффективность одномоментного TIPS и частичной эмболизации селезенки. Контрольное обследование проводили на 3, 6, 9, 12, 15-м месяце после операции.</p></sec><sec><title>Результаты</title><p>Результаты. Из 100 пациентов с циррозом печени клинико-инструментальные признаки портальной гипертензии диагностированы у 86. У 49 (56,9%) больных портальная гипертензия проявлялась варикозным расширением вен пищевода и (или) желудка с гиперспленизмом. При совместном использовании TIPS и частичной эмболизации селезенки госпитальной летальности и послеоперационных осложнений не зафиксировано. При динамическом наблюдении было 2 (10%) летальных исхода, не связанных с кровотечением из варикозно расширенных вен. Выраженность варикозного расширения уменьшилась у 19 (95%) больных, осталась неизменной у 1 (5%) больного. У 5 (25%) пациентов отмечено усугубление энцефалопатии. Через 6 мес после процедуры прирост уровня тромбоцитов составил 109,44 ± 34,26% (54–242), через 12 мес – 96,37 ± 23,62% (41–166). Средний прирост уровня лейкоцитов к концу 6-го месяца наблюдения составил 34,14 ± 24,96% (0–89), к концу 12-го месяца – 21,47 ± 18,46% (0–62).</p></sec><sec><title>Заключение</title><p>Заключение. Более половины пациентов с циррозом печени и портальной гипертензией имеют как варикозное расширение вен пищевода и (или) желудка, так и гиперспленизм. Симультанное выполнение TIPS и частичной эмболизации селезенки у этой категории больных безопасно и эффективно.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To improve treatment results in patients with various manifestations of portal hypertension (PH) by simultaneously performing transjugular intrahepatic portosystemic shunt (TIPS) placement and partial splenic embolization.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. At the first stage of the study, the incidence of PH manifestations was retrospectively analyzed in 100 consecutive patients with cirrhosis. At the second stage, the safety and efficacy of simultaneously performing TIPS placement and partial splenic embolization were evaluated in a group of 20 patients with esophageal and/or gastric varices and hypersplenism. Control examination was performed at 3, 6, 9, 12, and 15 months after the procedure.</p></sec><sec><title>Results</title><p>Results. Of 100 patients with liver cirrhosis, clinical and instrumental signs of portal hypertension were observed in 86 patients. In 49 (56.9%) patients, portal hypertension was manifested as esophageal and/or gastric varices along with hypersplenism. When TIPS and partial splenic embolization were used together, no in-hospital case fatality and postoperative complications were noted. During a dynamic observation, 2 (10%) fatal outcomes were reported that were not related to variceal bleeding. The severity of varices decreased in 19 (95%) patients while remaining unchanged in 1 (5%) patient. In 5 (25%) patients, encephalopathy was noted to worsen. Six months following the procedure, the platelet count increase reached 109.44 ± 34.26% (54–242), while 12 months later, it amounted to 96.37 ± 23.62% (41–166). After a 6-month follow-up period, an average increase in leukocyte count reached 34.14 ± 24.96% (0–89), amounting to 21.47 ± 18.46% (0–62) after a follow-up period of 12 months.</p></sec><sec><title>Conclusion</title><p>Conclusion. More than half of patients with cirrhosis and portal hypertension suffer from both esophageal and/or gastric varices and hypersplenism. In such patients, it is safe and effective to perform TIPS and partial splenic embolization simultaneously.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>печень</kwd><kwd>цирроз</kwd><kwd>портальная гипертензия</kwd><kwd>гиперспленизм</kwd><kwd>трансъюгулярное внутрипеченочное портосистемное шунтирование</kwd><kwd>TIPS</kwd><kwd>частичная эмболизация селезенки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver</kwd><kwd>cirrhosis</kwd><kwd>portal hypertension</kwd><kwd>hypersplenism</kwd><kwd>transjugular intrahepatic portosystemic shunt</kwd><kwd>TIPS</kwd><kwd>partial splenic embolization</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Маевская М.В., Павлов Ч.С., Федосьина Е.А., Бессонова Е.Н., Пирогова И.Ю., Гарбузенко Д.В. 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