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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">hepato</journal-id><journal-title-group><journal-title xml:lang="ru">Анналы хирургической гепатологии</journal-title><trans-title-group xml:lang="en"><trans-title>Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-5464</issn><issn pub-type="epub">2408-9524</issn><publisher><publisher-name>НЭИКОН ИСП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.16931/1995-5464.2022-3-33-45</article-id><article-id custom-type="elpub" pub-id-type="custom">hepato-927</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПОВЫШЕНИЕ РАДИКАЛЬНОСТИ ОПЕРАЦИЙ ПРИ ОПУХОЛЯХ ПЕЧЕНИ И ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ</subject></subj-group></article-categories><title-group><article-title>Трансплантация печени при метастазах нейроэндокринных опухолей. Обзор литературы и клиническое наблюдение</article-title><trans-title-group xml:lang="en"><trans-title>Liver transplantation for metastases from neuroendocrine tumors: a literature review and clinical observation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5691-5398</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Восканян</surname><given-names>С. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Voskanyan</surname><given-names>S. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Восканян Сергей Эдуардович – доктор мед. наук, профессор, член-корр. РАН, заместитель главного врача по хирургической помощи – руководитель Центра хирургии и трансплантологии; заведующий кафедрой хирургии с курсами онкохирургии, эндоскопии, хирургической патологии, клинической трансплантологии и органного донорства</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Sergey E. Voskanyan – Doct. of Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Deputy Chief Physician for Surgical Care, Head of the Center for Surgery and Transplantology; Head of the Department of Surgery with Courses in Surgical Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology, and Organ Donation of the Institute of Postgraduate Professional Education</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">voskanyan_se@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1784-5945</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артемьев</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Artemiev</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Артемьев Алексей Игоревич – канд. мед. наук, заведующий хирургическим отделением №2 Центра хирургии и трансплантологии</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Alexey I. Artemiev – Cand. of Sci. (Med.), Head of Surgical Department No. 2, the Center for Surgery and Transplantation; Associate Professor, the Department of Surgery with Courses in Surgical Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology, and Organ Donation of the Institute of Postgraduate Professional Education</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">coma2000@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9753-4345</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Найденов</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naidenov</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Найденов Евгений Владимирович – канд. мед. наук, врач-хирург хирургического отделения №2, старший научный сотрудник лаборатории новых хирургических технологий №50 Центра хирургии и трансплантологии; доцент кафедры хирургии с курсами онкохирургии, эндоскопии, хирургической патологии, клинической трансплантологии и органного донорства</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Evgenii V. Naidenov – Cand. of Sci. (Med.), Surgeon, Surgical Department No. 2, Senior Researcher, Laboratory of New Surgical Technologies No. 50, Center for Surgery and Transplantology; Associate Professor, the Department of Surgery with Courses in Surgical Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology, and Organ Donation of the Institute of Postgraduate Professional Education</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">e.v.naydenov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5724-6998</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Забежинский</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zabezhinsky</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Забежинский Дмитрий Александрович – канд. мед. наук, врач-хирург хирургического отделения №2 Центра хирургии и трансплантологии</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Dmitry A. Zabezhinsky – Cand. of Sci. (Med.), Surgeon, Surgical Department No. 2, the Center for Surgery and Transplantology</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">dzab@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4527-0448</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабалин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabalin</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попов Максим Васильевич – канд. мед. наук, врач по рентгенэндоваскулярным диагностике и лечению отделения рентгенохирургических методов диагностики и лечения</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Maxim V. Shabalin – Cand. of Sci. (Med.), Surgeon, Surgical Department No. 1, the Center for New Surgical Technologies</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">shabalin.max.v@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6558-7143</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попов Максим Васильевич – канд. мед. наук, врач по рентгенэндоваскулярным диагностике и лечению отделения рентгенохирургических методов диагностики и лечения</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Maxim V. Popov – Cand. of Sci. (Med.), Physician in X-ray Endovascular Diagnosis and Treatment, the Department of X-ray Surgical Methods of Diagnosis and Treatment</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">maximmsk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4560-6415</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Башков</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Bashkov</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Башков Андрей Николаевич – канд. мед. наук, заведующий отделением лучевой и радиоизотопной диагностики</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Andrey N. Bashkov – Cand. of Sci. (Med.), Head of the Department of Radiological and Radioisotope Diagnostics</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">abashkov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9006-163X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Губарев</surname><given-names>К К.</given-names></name><name name-style="western" xml:lang="en"><surname>Gubarev</surname><given-names>K. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Губарев Константин Константинович – канд. мед. наук, заведующий хирургическим отделением Центра координации донорства органов и (или) тканей человека, руководитель Центра ЭКМО</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Konstantin K. Gubarev – Cand. of Sci. (Med.), Head of the Surgical Department, the Center for the Coordination of Human Organ and/or Tissue Donation, Head of the ECMO Center</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">kkgubarev@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3171-6621</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудаков</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudakov</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рудаков Владимир Сергеевич – канд. мед. наук, врач-хирург Центра координации донорских органов и (или) тканей человека Центра хирургии и трансплантологии</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Vladimir S. Rudakov – Cand. of Sci. (Med.), Surgeon, the Center for the Coordination of Human Organ and/or Tissue Donation, the Center for Surgery and Transplantology</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">Rudakov_vc@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9344-4206</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Видмер</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vidmer</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Видмер Елена Викторовна – аспирант кафедры хирургии с курсами онкохирургии, эндоскопии, хирургической патологии, клинической трансплантологии и органного донорства ИППО ФГБУ</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Elena V. Vidmer – Graduate Student, the Department of Surgery with Courses in Surgical Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology, and Organ Donation, the Institute of Graduate Studies</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">idlen@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1768-1351</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Журбин</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhurbin</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Журбин Алексей Сергеевич – младший научный сотрудник лаборатории новых хирургических технологий №50 Центра хирургии и трансплантологии</p><p>123098, Москва, ул. Маршала Новикова, д. 23, Российская Федерация</p></bio><bio xml:lang="en"><p>Alexey S. Zhurbin – Junior Researcher, Laboratory of New Surgical Technologies No. 50, the Center for Surgery and Transplantology</p><p>23, Marshal Novikov str., Moscow, 123098, Russian Federation</p></bio><email xlink:type="simple">jas89@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБУ “Государственный научный центр Российской Федерации – Федеральный медицинский биофизический центр им. А.И. Бурназяна Федерального медико-биологического агентства”<country>Россия</country></aff><aff xml:lang="en">State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>20</day><month>09</month><year>2022</year></pub-date><volume>27</volume><issue>3</issue><fpage>33</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Восканян С.Э., Артемьев А.И., Найденов Е.В., Забежинский Д.А., Шабалин М.В., Попов М.В., Башков А.Н., Губарев К.К., Рудаков В.С., Видмер Е.В., Журбин А.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Восканян С.Э., Артемьев А.И., Найденов Е.В., Забежинский Д.А., Шабалин М.В., Попов М.В., Башков А.Н., Губарев К.К., Рудаков В.С., Видмер Е.В., Журбин А.С.</copyright-holder><copyright-holder xml:lang="en">Voskanyan S.E., Artemiev A.I., Naidenov E.V., Zabezhinsky D.A., Shabalin M.V., Popov M.V., Bashkov A.N., Gubarev K.K., Rudakov V.S., Vidmer E.V., Zhurbin A.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://hepato.elpub.ru/jour/article/view/927">https://hepato.elpub.ru/jour/article/view/927</self-uri><abstract><p>Нейроэндокринные опухоли представляют собой редкую и гетерогенную группу новообразований с различным злокачественным потенциалом, которые часто метастазируют в печень и требуют активного комплексного лечения. При нерезектабельных нейроэндокринных опухолях с метастазами в печени трансплантация стала потенциальным радикальным методом лечения ввиду медленного роста и течения метастатического процесса. Проведен обзор литературы, критериев включения и исключения пациентов для трансплантации печени, альтернативных методов лечения при нейроэндокринных опухолях. Приведено клиническое наблюдение этапного комбинированного лечения пациентки с нейроэндокринной опухолью тонкой кишки и билобарными нерезектабельными метастазами в печени. Показаны удовлетворительные отдаленные результаты трансплантации печени.</p></abstract><trans-abstract xml:lang="en"><p>Neuroendocrine tumors are a rare and heterogeneous group of neoplasms with different malignant potential. They often metastasize to the liver and require active combined therapy. For unresectable neuroendocrine tumors with liver metastases, transplantation has become a potential definitive treatment due to the slow growth and the clinical course of the metastatic process. We conducted a review of relevant literature, the criteria for including and excluding patients considered for liver transplantation as well as alternative methods of treatment of neuroendocrine tumors. The paper presents a clinical observation of a staged combined therapy of a patient with a neuroendocrine tumor of the small intestine and bilobar unresectable liver metastases. The study demonstrates satisfactory long-term results of liver transplantation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>печень</kwd><kwd>трансплантация</kwd><kwd>нейроэндокринные опухоли</kwd><kwd>метастазы</kwd><kwd>выживаемость</kwd><kwd>отдаленные результаты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver</kwd><kwd>transplantation</kwd><kwd>neuroendocrine tumors</kwd><kwd>metastases</kwd><kwd>survival rate</kwd><kwd>long-term results</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ilić D., Kunac N., Borčić T., Kujundžić P.D., Dolić Z.M., Sobočan N., Lalovac M., Mijić M., Međimurec G., Kocman B., Mikolašević I., Filipec Kanižaj T.F. Liver transplantation in patients with neuroendocrine tumors: a case series and literature review. Croat. Med. 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