Оценка качества жизни больных, оперированных по поводу злокачественных новообразований поджелудочной железы и периампулярной зоны. Систематический обзор

   Цель. Анализ актуальных методов оценки качества жизни пациентов, проходящих хирургическое лечение по поводу рака поджелудочной железы и периампулярной зоны, изучение влияния хирургического лечения и послеоперационных осложнений на качество жизни.

   Материал и методы. Проведен систематический обзор литературы, содержащейся в электронных базах данных MEDLINE, Embase и e-Library, за 2015–2022 гг. Методология систематического обзора отражена в протоколе исследования, составленного в соответствии с рекомендациями PRISMA.

   Результаты. В систематический обзор вошли 26 исследований, включавших 4937 пациентов, отвечающих критериям включения. Были изучены такие характеристики исследований, как дизайн и задачи, опросные формы, методы хирургического и лекарственного лечения, периодичность опроса и методика сбора данных, риск систематической ошибки и др.

   Заключение. При выборе опросной формы большинство авторов отдавали предпочтение EORTC QLQ-C30 и EORTC QLQ-PAN26. Даже наиболее сложные операции, такие как панкреатодуоденальная резекция и панкреатэктомия, позволяют добиться удовлетворительного качества жизни. Во многих актуальных исследованиях присутствуют методологические недостатки, увеличивающие риск систематической ошибки и уменьшающие достоверность полученных данных. Необходимо дальнейшее изучение качества жизни пациентов этой категории, стандартизация оптимальных принципов и методологии проведения подобных исследований, в частности, в отечественном здравоохранении.

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