Long-term survival of patients with advanced intrahepatic cholangiocarcinoma after regional chemotherapy

The paper presents the results of successful regional chemotherapy applied in the treatment of two patients with unresectable cholangiocellular carcinoma. In the first case, a 57-year-old female patient with metastatic cholangiocarcinoma demonstrated an overall survival of 8 years following a regimen that combined systemic and regional chemotherapy. Within 6.5 years, the patient underwent 25 cycles of endovascular treatment, three of which were conducted post-relief of mechanical jaundice using a stent. The adverse effects of chemotherapy, characterized by mild anemia and thrombocytopenia, necessitated no additional treatment. In the second case, a 73-year-old patient with bilobed tumor underwent 31 cycles of regional chemotherapy in combination with systemic therapy; the overall survival accounted for 5 years. The combination of regional and systemic chemotherapy can be considered safe and effective for the management of advanced cholangiocellular carcinoma. The combination of endovascular chemoembolization and chemoinfusion is regarded as promising.

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