Efficacy of nonsteroidal anti-inflammatory drugs in transpapillary interventions: a single-center cohort study

Aim. To determine the efficacy of nonsteroidal anti-inflammatory drugs in preventing the development of pancreatitis following endoscopic retrograde interventions.

Materials and methods. The study enrolled 865 patients who underwent transpapillary interventions for various hepatopancreatoduodenal diseases from 2019 to 2023. Patients in the main group (n = 470) were additionally prescribed Diclofenac suppositories (100 mg) 20–30 minutes prior to the procedure.

Results. In the main group, acute post-ERCP pancreatitis developed 1.8 times less frequently than in the control group. Nonsteroidal anti-inflammatory drugs reduced the incidence of acute post-ERCP pancreatitis by 3.6% (p = 0.006).

Conclusion. Nonsteroidal anti-inflammatory drugs decrease the incidence of acute post-endoscopic retrograde cholangiopancreatography (post-ERCP) pancreatitis. Regardless of their application, additional measures for preventing complications are required. The role of nonsteroidal anti-inflammatory drugs in preventing complications following endoscopic retrograde interventions warrants further research in larger patient groups.

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