Efficacy of nonsteroidal anti-inflammatory drugs in transpapillary interventions: a single-center cohort study
https://doi.org/10.16931/1995-5464.2024-4-115-121
Abstract
Aim. To determine the efficacy of nonsteroidal anti-inflammatory drugs in preventing the development of pancreatitis following endoscopic retrograde interventions.
Materials and methods. The study enrolled 865 patients who underwent transpapillary interventions for various hepatopancreatoduodenal diseases from 2019 to 2023. Patients in the main group (n = 470) were additionally prescribed Diclofenac suppositories (100 mg) 20–30 minutes prior to the procedure.
Results. In the main group, acute post-ERCP pancreatitis developed 1.8 times less frequently than in the control group. Nonsteroidal anti-inflammatory drugs reduced the incidence of acute post-ERCP pancreatitis by 3.6% (p = 0.006).
Conclusion. Nonsteroidal anti-inflammatory drugs decrease the incidence of acute post-endoscopic retrograde cholangiopancreatography (post-ERCP) pancreatitis. Regardless of their application, additional measures for preventing complications are required. The role of nonsteroidal anti-inflammatory drugs in preventing complications following endoscopic retrograde interventions warrants further research in larger patient groups.
About the Authors
V. Yu. DynkoRussian Federation
Viktor Yu. Dynko – Cand. of Sci. (Med.), Head of the Endoscopy Department, Regional Clinical Hospital No. 2.
6, building 2, Krasnykh Partizan str., Krasnodar, 350012
A. K. Mamishev
Russian Federation
Adam K. Mamishev – Endoscopist, Endoscopic Department, Regional Clinical Hospital No. 2.
6, building 2, Krasnykh Partizan str., Krasnodar, 350012
S. A. Gabriel
Russian Federation
Sergey A. Gabriel – Doct. of Sci. (Med.), Professor, Surgery Department No. 3, Faculty of Advanced Training and Retraining, Kuban State Medical University of Public Health Care of Russia; Endoscopist, Chief Physician, Regional Clinical Hospital No. 2.
6, building 2, Krasnykh Partizan str., Krasnodar, 350012
V. V. Kulagin
Russian Federation
Vyacheslav V. Kulagin – Endoscopist, Endoscopic Department, Regional Clinical Hospital No. 2.
6, building 2, Krasnykh Partizan str., Krasnodar, 350012
A. D. Gritsay
Russian Federation
Alisa D. Gritsay – 4th Year Student, Faculty of Medicine, Kuban State Medical University of Public Health Care of Russia.
4, Sedina str., Krasnodar, 350063
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Supplementary files
Review
For citations:
Dynko V.Yu., Mamishev A.K., Gabriel S.A., Kulagin V.V., Gritsay A.D. Efficacy of nonsteroidal anti-inflammatory drugs in transpapillary interventions: a single-center cohort study. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2024;29(4):115-121. (In Russ.) https://doi.org/10.16931/1995-5464.2024-4-115-121