Enucleation and resections short-term operative outcomes for well-differentiated pancreatic neuroendocrine tumors

Aim. To evaluate the short-term outcomes of enucleation and resection procedures for G1 and G2 pancreatic neuroendocrine tumors (PNETs).

Materials and Methods. The study included 171 patients diagnosed with G1 and G2 pancreatic neuroendocrine tumors. Pancreatoduodenectomy was performed in 25 patients, distal pancreatic resection in 60, and tumor enucleation in 86 cases.

Results. Neuroendocrine tumors in the head and neck of the pancreas were identified in 79 patients. Enucleation was performed in 54 cases, and pancreatoduodenectomy in 25. Postoperative complications following enucleation occurred in 22 patients (40.7%), with 1 death; complications after pancreatoduodenectomy were observed in 9 patients (36%), also with 1 death. Tumors located in the body and tail were diagnosed in 92 patients. Enucleation was performed in 32 cases, and distal pancreatic resection in 60. Postoperative complications occurred in 5 patients (15.6%) after enucleation and in 27 patients (45.5%) after distal pancreatic resection.

Conclusion. For well-differentiated pancreatic neuroendocrine tumors, enucleation is a feasible surgical option. The choice of surgical procedure depends on tumor size, its anatomic location with respect to the main pancreatic duct, and the surgeon’s clinical judgment.

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