Внутрипротоковые папиллярные муцинозные неоплазии поджелудочной железы в ассоциации с протоковым раком – две раздельные клинические сущности

Цель. Анализ последних взглядов на концепцию злокачественной прогрессии внутрипротоковой папиллярной муцинозной опухоли поджелудочной железы и наиболее значимых перспектив научных исследований в этой области.

Материал и методы. Обзор литературных данных, анализ данных канцер-регистра г. Москвы. Результаты. Приведены наиболее значимые молекулярно-генетические исследования за последние десятилетия. На примере анализа данных операционного материала по кодам ICD-O г. Москвы за 2023–2024 гг. рассмотрены основные трудности морфологической диагностики внутрипротоковой папиллярной муцинозной опухоли поджелудочной железы с ассоциированной инвазивной карциномой.

Заключение. Геномные изменения во внутрипротоковой папиллярной муцинозной опухоли поджелудочной железы как фоновые поражения для протокового рака поджелудочной железы, обусловливающие их генетическую гетерогенность, имеют большое клиническое значение для понимания поликлональной теории развития рака, поиска новых мишеней и подходов в терапии. Ассоциированный инвазивный компонент во внутрипротоковой папиллярной муцинозной опухоли поджелудочной железы, согласно своему молекулярному профилю, чаще является генетически независимым.

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