Intraductal papillary mucinous neoplasms of the pancreas associated with ductal carcinoma as two distinct clinical entities
https://doi.org/10.16931/1995-5464.2025-3-53-62
Abstract
Aim. To analyze current perspectives on the concept of malignant progression in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and to outline the most prospective research trends in this area.
Materials and Methods. A literature review and an analysis of data from the cancer registry of Moscow were conducted. Results. The paper summarizes key molecular genetic studies from recent decades. Using surgical specimen data coded according to ICD-O in Moscow for the years 2023–2024, the main challenges in the histopathological diagnosis of IPMN with associated invasive carcinoma are discussed.
Conclusion. Genomic alterations in IPMNs of the pancreas, as background lesions for pancreatic ductal adenocarcinoma, reflect their genetic heterogeneity and carry significant clinical implications for understanding the polyclonal theory of carcinogenesis, as well as for identifying novel therapeutic targets and approaches. The invasive component associated with IPMN is frequently genetically independent based on its molecular profile.
About the Authors
O. V. Paklina
Moscow Clinical Scientific Center named after A.S. Loginov; A.V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Oksana V. Paklina – Doct. of Sci. (Med.), Scientific Consultant of the Laboratory of Innovative Pathomorphology; Chief Researcher at the Electron Microscopy Laboratory of the Department of Pathological Anatomy
86, Sh. Entuziastov, Moscow, 111123
27, str. Bolshaya Serpukhovskaya, Moscow, 115093
K. K. Noskova
Moscow Clinical Scientific Center named after A.S. Loginov
Russian Federation
Russian Federation
Karina K. Noskova – Cand. of Sci. (Med.), Head of the Department of Clinical and Laboratory Diagnostics
86, Sh. Entuziastov, Moscow, 111123
I. S. Abramov
Moscow Clinical Scientific Center named after A.S. Loginov
Russian Federation
Russian Federation
Biologist of the Moscow City Medical and Genetic Center
86, Sh. Entuziastov, Moscow, 111123
N. A. Bodunova
Moscow Clinical Scientific Center named after A.S. Loginov
Russian Federation
Russian Federation
Natalia A. Bodunova – Cand. of Sci. (Med.), Head of the Center for Personalized Medicine, Director of the Moscow City Medical and Genetic Center
86, Sh. Entuziastov, Moscow, 111123
N. A. Savelov
Moscow City Oncology Hospital No. 62 of the Moscow Healthcare Department
Russian Federation
Russian Federation
Nikita A. Savelov – Head of the City Center for Pathoanatomic Diagnostics and Molecular Genetics
27, bld. 1-30, Istra settlement, Krasnogorsk urban district, Moscow region, 143515
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For citations:
Paklina O.V., Noskova K.K., Abramov I.S., Bodunova N.A., Savelov N.A. Intraductal papillary mucinous neoplasms of the pancreas associated with ductal carcinoma as two distinct clinical entities. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2025;30(3):53-62. (In Russ.) https://doi.org/10.16931/1995-5464.2025-3-53-62
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