Ultrasound Ablation (HIFU) in the Treatment of Pancreatic Unresectable Tumors
O. E. Karpov,
P. S. Vetshev,
S. V. Bruslik,
T. I. Sviridova,
A. L. Levchuk,
V. O. Sarzhevskiy,
V. V. Sudilovskaya
https://doi.org/10.16931/1995-5464.2015317-23
Memorial Healthcare Group. Cancer of the pancreas, newest methods of its treatment. In-t, Memorial. 23.10.12.
Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 2015; 136 (5): Е359–Е386. doi:10.1002/ijc.29210. PMID:25220842.
Shchipotin I.B., Lukashenko A.V., Kolesnik E.A., Rasumey D.A., Priymak V.V., Shcheptitskiy V.V., Golovko G.S., Lavrik G.V., Khalileev A.A. Pancreatic cancer: resectability criteria. Klinicheskaja onkologija. 2011; 4 (4): 1–7. (In Russian)
Ionescu M., Stroescu C., Ciurea S., Dragnea A., Dumitrascu T., Tanase A.M., Popescu I. The value of resection in pancreatic cancer: the analysis of an experience of 180 patients in 10 years. Chirurgia (Bucur). 2004; 99 (4): 211–220. PMID: 15560556.
Davydov M.I., Aksel' E.M. The statistic of neopalsms in Russia and CIS countries in 2004. Vestnik Rossijskogo onkologicheskogo nauchnogo centra im. N.N. Blohina RAMN. 2006; 17 (3, App.): 132 p. (In Russian)
Patyutko Yu.I., Kotel'nikov A.G., Kosyrev V.Yu. Modern data about the possibilities of surgical treatment of patients with pancreas and ampullary area cancer. Sovremennaja onkologija. 2000; 1 (2): 12–15. (In Russian)
Kubyshkin V.A., Vishnevskiy V.A., Danilov M.V., Buriev I.M., Vukolov A.V. The assessment of pancreatoduodenectomy completion. Khirurgija. 2001; 1: 46–50. (In Russian)
Kubyshkin V.A., Vishnevskiy V.A. Rak podzheludochnoj zhelezy [Pancreatic cancer]. Moscow: Medpraktika, 2003. 386 p. (In Russian)
Karimov Sh.I., Borovskiy S.P., Khakimov M.Sh., Adylkhodzhaev A.A. Local chemotherapy in treatment of unresectable pancreatic tumors. Annaly khirurgicheskoj gepatologii. 2010; 15 (3): 105–109. (In Russian)
Engelken F.J., Bettschart V., Rahman M.Q., Parks R.W., Garden O.J. Prognostic factors in the palliation of pancreatic cancer. Eur. J. Surg. Oncol. 2003; 29 (4): 368–373. PMID: 12711291.
Gudjonsson B. Carcinoma of the pancreas: critical analysis of costs, results of resections, and the need for standardized reporting. J. Am. Coll. Surg. 1995; 181 (6): 483–503.
Tempero M.A., Malafa M.P., Behrman S.W., Benson A.B. 3rd, Casper E.S., Chiorean E.G., Chung V., Cohen S.J., Czito B., Engebretson A., Feng M., Hawkins W.G., Herman J., Hoffman J.P., Ko A., Komanduri S., Koong A., Lowy A.M., Ma W.W., Merchant N.B., Mulvihill S.J., Muscarella P. 2nd, Nakakura E.K., Obando J., Pitman M.B., Reddy S., Sasson A.R., Thayer S.P., Weekes C.D., Wolff R.A., Wolpin B.M., Burns J.L., Freedman-Cass D.A. Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. J. Natl. Compr. Canc. Netw. 2014; 12 (8): 1083–1093. PMID: 25099441.
Granov A.M., Pavlovskiy A.V., Granov D.A. Modern technologies in diagnosis and treatment of pancreatic cancer. Medicinskij akademicheskij zhurnal. 2003; 4: 41–53. (In Russian)
Granov A.M., Davydov M.I. Intervencionnaja radiologija v onkologii [Interventional Radiology in Oncology]. Saint-Petersburg, 2013. Р. 305–320. (In Russian)
Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Serebryanik P.S. HIFU-technology opportunities in treatment of patients with tumors in multidisciplinary hospital. Vestnik Nacional'nogo mediko-hirurgicheskogo сentra im. N.I. Pirogova. 2009; 4 (2): 3–8. (In Russian)
Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Sudilovskaya V.V. Ul'trazvukovaja abljacija (HIFU) metastaticheskogo raka pecheni i nerezektabel'nyh opuholej podzheludochnoj zhelezy [Ultrasound ablation (HIFU) for metastatic liver cancer and unresectable pancreatic tumors]. The materials of the Plenum of the Board of the Association of surgeons-hepatologists of CIS. Izhevsk, 2012. Р. 34. (In Russian)
Sviridovа T.I., Bruslik S.V., Vetshev P.S. The distant local destruction of liver tumors. Vestnik Nacional'nogo medikohirurgicheskogo centra im. N.I. Pirogova. 2013; 8 (4): 112–118. (In Russian)
Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Sudilovskaya V.V. Ul'trazvukovaja abljacija (HIFU) metastaticheskogo raka pecheni i nerezektabel'nyh opuholej podzheludochnoj zhelezy [Ultrasound ablation (HIFU) for metastatic liver cancer and unresectable pancreatic tumors]. Proceedings of the 2nd Congress of the Russian public organization “Russian Society of surgeonsgastroenterologists” on “Actual problems of surgical gastroenterology”. Gelendzhik, 2012. Р. 78. (In Russian)
Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Sudilovskaya V.V. Ul'trazvukovaja abljacija (HIFU) metastaticheskogo raka pecheni i nerezektabel'nyh opuholej podzheludochnoj zhelezy [Ultrasound ablation (HIFU) for metastatic liver cancer and unresectable pancreatic tumors]. Proceedings of the VIII International Conference of Surgeons-hepatologists of CIS countries “Vakhidov reading-2012”. Samarkand, 2012. Р. 141. (In Russian)
Sviridova T.I., Bruslik S.V., Vetshev P.S. Noninvasive ultrasound ablation of liver tumors. Annaly khirurgicheskoj gepatologii. 2014; 19 (1): 110–119. (In Russian)
Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Chapaeva V.Yu., Sarzhevskiy V.O., Sudilovskaya V.V. Ul'trazvukovaja abljacija (HIFU) nerezektabel'nyh opuholej podzheludochnoj zhelezy [Ultrasound ablation (HIFU) for unresectable pancreatic tumors]. Abstracts of the Plenum of the Board hepatopancreatobiliary surgeons CIS. Tyumen, 2014. P. 42. (In Russian)
Karpov O.E., Vetshev P.S., Levchuk A.L., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Sarzhevskiy V.O. Ul'trazvukovaja abljacija (HIFU) nerezektabel'nyh opuholej podzheludochnoj zhelezy [Ultrasound ablation (HIFU) for unresectable pancreatic tumors]. Proceedings of the conference “Mistakes and complications in surgical gastroenterology”. Gelendzhik, 2014. P. 150. (In Russian)
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Full Text:
Abstract
Aim. The define possibility of minimally invasive and non-invasive techniques in treatment of patients with unresectable pancreatic tumors.
Materials and Methods. We have analyzed 18 ablations in 16 patients. There were 11 (69%) women and 5 (31%) men. Average size of tumor was 3.5±1.5 cm. In 50% of cases unresectable pancreatic tumor was complicated by obstructive jaundice. All patients had pain syndrome.
Results. The pain decreased or disappeared in 72% of patients after operation. Decrease of tumor's size was confirmed in all cases. Pain syndrome disappeared in 7 of 11 patients and body mass increased during 48 months of follow-up.
Conclusion. Combined staged minimally invasive techniques including external bile ducts drainage, common bile duct stenting and non-invasive HIFU-ablation enhances complex treatment of patients with unresectable pancreatic tumors. It is accompanied by favorable prognosis and improves the quality of life
About the Authors
O. E. Karpov
N.I. Pirogov National Medical Surgical Center of the Russian Ministry of Health
Russian Federation
Russian Federation
Doct. of Med. Sci., Professor, the Chief Executive Officer of the N.I. Pirogov National Medical Surgical Center, Honored Doctor of the Russian Federation
P. S. Vetshev
N.I. Pirogov National Medical Surgical Center of the Russian Ministry of Health
Russian Federation
Russian Federation
Doct. of Med. Sci., Professor, the Deputy of the Chief Executive Officer for Medical, Scientific and Educational Work of the N.I. Pirogov National Medical Surgical Center, Honored Doctor of the Russian Federation
S. V. Bruslik
N.I. Pirogov National Medical Surgical Center of the Russian Ministry of Health
Russian Federation
Russian Federation
Cand. of Med. Sci., Associate Professor, Head of the Department of Ultrasonic Diagnosis and Radiosurgical Methods of Diagnosis and Treatment, N.I. Pirogov National Medical Surgical Center
T. I. Sviridova
N.I. Pirogov National Medical Surgical Center of the Russian Ministry of Health
Russian Federation
Russian Federation
Cand. of Med. Sci., Doctor of Ultrasound Diagnostics at the Department of Ultrasonic Diagnosis and Radiosurgical Methods of Diagnosis and Treatment, N.I. Pirogov National Medical Surgical Center
A. L. Levchuk
N.I. Pirogov National Medical Surgical Center of the Russian Ministry of Health
Russian Federation
Russian Federation
Doct. of Med. Sci., Professor, Head of the Surgical Department
№2 of N.I. Pirogov National Medical Surgical Center
V. O. Sarzhevskiy
N.I. Pirogov National Medical Surgical Center of the Russian Ministry of Health
Russian Federation
Russian Federation
Cand. of Med. Sci., Associate Professor, the Oncologist at the A.A. Maximov Clinic of Hematology and Cell Therapy, N.I. Pirogov National Medical Surgical Center
V. V. Sudilovskaya
N.I. Pirogov National Medical Surgical Center of the Russian Ministry of Health
Russian Federation
Cand. of Med. Sci., Pathologist, N.I. Pirogov National Medical Surgical Center
Russian Federation
Cand. of Med. Sci., Pathologist, N.I. Pirogov National Medical Surgical Center
References
1. Memorial Healthcare Group. Cancer of the pancreas, newest methods of its treatment. In-t, Memorial. 23.10.12.
2. Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 2015; 136 (5): E359-E386. https://doi.org/10.1002/ijc.29210. PMID: 25220842.
3. Shchipotin I.B., Lukashenko A.V., Kolesnik E.A., Razumei D.A., Priimak V.V., Shcheptitskii V.V., Golovko G.S., Lavrik G.V., Khalileev A.A. Rak podzheludochnoi zhelezy: kriterii rezektabel'nosti. Klinicheskaya onkologiya. 2011; 4 (4): 1-7.
4. Ionescu M., Stroescu C., Ciurea S., Dragnea A., Dumitrascu T., Tanase A.M., Popescu I. The value of resection in pancreatic cancer: the analysis of an experience of 180 patients in 10 years. Chirurgia (Bucur). 2004; 99 (4): 211-220. PMID: 15560556.
5. Davydov M.I., Aksel' E.M. Statistika zlokachestvennykh novoobrazovanii v Rossii i stranakh SNG v 2004 godu. Vestnik RONTs im. N.N. Blokhina RAMN. 2006; 17 (3, Prilozhenie): 132 s.
6. Patyutko Yu.I., Kotel'nikov A.G., Kosyrev V.Yu. Sovremennye dannye o vozmozhnostyakh khirurgicheskogo lecheniya bol'nykh rakom podzheludochnoi zhelezy i periampulyarnoi zony. Sovremennaya onkologiya. 2000; 1 (2): 12-15.
7. Kubyshkin V.A., Vishnevskii V.A., Danilov M.V., Buriev I.M., Vukolov A.V. Otsenka zaversheniya pankreatoduodenal'noi rezektsii. Khirurgiya. 2001; 1: 46-50.
8. Kubyshkin V.A., Vishnevskii V.A. Rak podzheludochnoi zhelezy. M.: Medpraktika, 2003. 386 c.
9. Karimov Sh.I., Borovskii S.P., Khakimov M.Sh., Adylkhodzhaev A.A. Regionarnaya khimioterapiya v lechenii ne rezektabel'nykh opukholei podzheludochnoi zhelezy. Annaly khirurgicheskoi gepatologii. 2010; 15 (3): 105-109.
10. Engelken F.J., Bettschart V., Rahman M.Q., Parks R.W., Garden O.J. Prognostic factors in the palliation of pancreatic cancer. Eur. J. Surg. Oncol. 2003; 29 (4): 368-373. PMID: 12711291.
11. Gudjonsson B. Carcinoma of the pancreas: critical analysis of costs, results of resections, and the need for standardized reporting. J. Am. Coll. Surg. 1995; 181 (6): 483-503.
12. Tempero M.A., Malafa M.P., Behrman S.W., Benson A.B. 3rd, Casper E.S., Chiorean E.G., Chung V., Cohen S.J., Czito B., Engebretson A., Feng M., Hawkins W.G., Herman J., Hoffman J.P., Ko A., Komanduri S., Koong A., Lowy A.M., Ma W.W., Merchant N.B., Mulvihill S.J., Muscarella P. 2nd, Nakakura E.K., Obando J., Pitman M.B., Reddy S., Sasson A.R., Thayer S.P., Weekes C.D., Wolff R.A., Wolpin B.M., Burns J.L., Freedman-Cass D.A. Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. J. Natl. Compr. Canc. Netw. 2014; 12 (8): 1083-1093. PMID: 25099441.
13. Granov A.M., Pavlovskii A.V., Granov D.A. Sovremennye tekhnologii diagnostiki i lecheniya raka podzheludochnoi zhelezy. Meditsinskii akademicheskii zhurnal. 2003; 4: 41-53.
14. Granov A.M., Davydov M.I. Interventsionnaya radiologiya v onkologii. SPb., 2013. S. 305-320.
15. Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Serebryanik P.S. Vozmozhnosti HIFU-tekhnologii v lechenii patsientov s opukholyami v mnogoprofil'nom statsionare. Vestnik Natsional'nogo mediko-khirurgicheskogo tsentra im. N.I. Pirogova. 2009; 4 (2): 3-8.
16. Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Sudilovskaya V.V. Ul'trazvukovaya ablyatsiya (HIFU) metastaticheskogo raka pecheni i nerezektabel'nykh opukholei podzheludochnoi zhelezy. Materialy Plenuma pravleniya Assotsiatsii khirurgov-gepatologov stran SNG. Izhevsk, 2012. S. 34.
17. Sviridova T.I., Bruslik S.V., Vetshev P.S. Distantsionnaya lokal'naya destruktsiya opukholei pecheni. Vestnik Natsional'nogo mediko-khirurgicheskogo tsentra im. N.I. Pirogova. 2013; 8 (4): 112-118.
18. Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Sudilovskaya V.V. Ul'trazvukovaya ablyatsiya (HIFU) metastaticheskogo raka pecheni i nerezektabel'nykh opukholei podzheludochnoi zhelezy. Materialy 2-go s"ezda Obshcherossiiskoi obshchestvennoi organizatsii “Rossiiskoe obshchestvo khirurgov-gastroenterologov” na temu “Aktual'nye voprosy khirurgicheskoi gastroenterologii”. Gelendzhik, 2012. S. 78.
19. Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Sudilovskaya V.V. Ul'trazvukovaya ablyatsiya (HIFU) metastaticheskogo raka pecheni i nerezektabel'nykh opukholei podzheludochnoi zhelezy. Tezisy VIII Mezhdunarodnoi konferentsii khirurgovgepatologov stran SNG “Vakhidovskie chteniya - 2012”. Samarkand, 2012. S. 141.
20. Sviridova T.I., Bruslik S.V., Vetshev P.S. Neinvazivnaya ul'trazvukovaya ablyatsiya opukholei pecheni. Annaly khirurgicheskoi gepatologii. 2014; 19 (1): 110-119.
21. Shevchenko Yu.L., Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Chapaeva V.Yu., Sarzhevskii V.O., Sudilovskaya V.V. Ul'trazvukovaya ablyatsiya (HIFU) nerezektabel'nykh opukholei podzheludochnoi zhelezy. Tezisy Plenuma pravleniya gepatopankreatobiliarnykh khirurgov stran SNG. Tyumen', 2014. S. 42.
22. Karpov O.E., Vetshev P.S., Levchuk A.L., Bruslik S.V., Sviridova T.I., Slabozhankina E.A., Sarzhevskii V.O. Ul'trazvukovaya ablyatsiya (HIFU) nerezektabel'nykh opukholei podzheludochnoi zhelezy. Materialy konferentsii “Oshibki i oslozhneniya v khirurgicheskoi gastroenterologii”. Gelendzhik, 2014. S. 150.
Review
For citations:
Karpov O.E., Vetshev P.S., Bruslik S.V., Sviridova T.I., Levchuk A.L., Sarzhevskiy V.O., Sudilovskaya V.V. Ultrasound Ablation (HIFU) in the Treatment of Pancreatic Unresectable Tumors. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2015;20(3):17-23. (In Russ.) https://doi.org/10.16931/1995-5464.2015317-23
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ISSN 2408-9524 (Online)
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