Minimally invasive technologies for ablation of pancreatic malignancies
P. S. Vetshev,
A. V. Chzhao,
D. A. Ionkin,
Yu. A. Stepanova,
O. I. Zhavoronkova,
Yu. V. Kulezneva,
O. V. Melekhina,
D. N. Panchenkov,
D. A. Astakhov,
Yu. V. Ivanov,
S. V. Bruslik,
T. I. Sviridova https://doi.org/10.16931/1995-5464.2019387-98
Abstract
Minimally invasive ablative technologies is a promising direction in the treatment of some cancer patients including pancreatic cancer. Cryodestruction, radiofrequency ablation, irreversible electroporation and ultrasound ablation show encouraging results regarding destruction of tumor tissue, cytoreduction. These methods are associated with small number of complications and relatively easy to tolerate by patients. However, there is no single approach to their use in the complex treatment of these patients. Accumulation of data followed by comparative analysis of various ablation techniques is being carried out in many specialized clinics of the world including national hospitals. Ablation mechanisms of technologies, literature data and the authors' own experience in the treatment of pancreatic cancer are reported in the article. Further randomized prospective trials are required to determine the role of ablation methods in the complex treatment of tumors of parenchymal organs including pancreatic cancer.
About the Authors
P. S. Vetshev
Pirogov National Medical Surgical Center of the Ministry of Health of Russia
Russian Federation
Russian Federation
Peter S. Vetshev – Doct. of Sci. (Med.), Professor, Deputy Chief for Medical and Scientific Work
Honored Doctor of Russian Federation, Chairman of the Coordination Council “Minimally Invasive Technologies under Ultrasound and X-ray Assistance” of the Association of Hepatopancreatobiliary Surgeons of the CIS Countries
A. V. Chzhao
Vishnevsky National Medical Research Center for Surgery
Aleksey V. Chzhao – Doct. of Sci. (Med.), Professor, Deputy Director for Scientific and Clinical Work
Aleksey V. Chzhao – Doct. of Sci. (Med.), Professor, Deputy Director for Scientific and Clinical Work
D. A. Ionkin
Vishnevsky National Medical Research Center for Surgery
Dmitriy A. Ionkin – Cand. of Sci. (Med.), Senior Research Fellow of the Department of Liver and Pancreatic Surgery
For correspondence: “Cryodestruction”: Dmitry A. Ionkin – 27, B. Serpukhovskaya str., Moscow, 117997. Phone: +7-916-654-84-83.
Yu. A. Stepanova
Vishnevsky National Medical Research Center for Surgery
Yulia A. Stepanova – Doct. of Sci. (Med.), Scientific Secretary
Yulia A. Stepanova – Doct. of Sci. (Med.), Scientific Secretary
O. I. Zhavoronkova
Vishnevsky National Medical Research Center for Surgery
Olga I. Zhavoronkova – Cand. of Sci. (Med.), Senior Research Fellow of the Department of Roentgenology and Magnetic Resonance Imaging with Ultrasound Diagnosis Room
Olga I. Zhavoronkova – Cand. of Sci. (Med.), Senior Research Fellow of the Department of Roentgenology and Magnetic Resonance Imaging with Ultrasound Diagnosis Room
Yu. V. Kulezneva
Loginov Moscow Clinical Scientific Center
Yulia V. Kulezneva – Doct. of Sci. (Med.), Head of the Department of Interventional Radiology
Yulia V. Kulezneva – Doct. of Sci. (Med.), Head of the Department of Interventional Radiology
O. V. Melekhina
Loginov Moscow Clinical Scientific Center
Olga V. Melekhina – Cand. of Sci. (Med.), Surgeon of the Department of Interventional Radioilogy
For correspondence: “Radiofrequency ablation”: Olga V. Melekhina – 86, Highway Enthusiastov, Moscow, 111123. Phone: +7-926-185-34-87
D. N. Panchenkov
Evdokimov Moscow State University of Medicine and Dentistry;
Federal Research Clinical Center for Specialized Types of Health Care and Medical Technologies of Federal Medical and Biology Agency
Dmitry N. Panchenkov – Doct. of Sci. (Med.), Professor, Head of the Laboratory of Minimally Invasive Surgery
Dmitry N. Panchenkov – Doct. of Sci. (Med.), Professor, Head of the Laboratory of Minimally Invasive Surgery
D. A. Astakhov
Evdokimov Moscow State University of Medicine and Dentistry;
Federal Research Clinical Center for Specialized Types of Health Care and Medical Technologies of Federal Medical and Biology Agency
Dmitry A. Astakhov – Cand. of Sci. (Med.), Leading Research Fellow of the Laboratory of Minimally Invasive Surgery
Oncologist of the Department of Oncology
For correspondence: “Irreversible electroporation”: Dmitry A. Astakhov – 28, Orekhovy Boulevard str., apt. 734, Moscow, 115682. Phone: +7-926-014-13-65
Yu. V. Ivanov
Evdokimov Moscow State University of Medicine and Dentistry;
Federal Research Clinical Center for Specialized Types of Health Care and Medical Technologies of Federal Medical and Biology Agency
Yury V. Ivanov – Doct. of Sci. (Med.), Professor, Head of the Department of Surgery № 1
Yury V. Ivanov – Doct. of Sci. (Med.), Professor, Head of the Department of Surgery № 1
S. V. Bruslik
Pirogov National Medical Surgical Center of the Ministry of Health of Russia
Sergey V. Bruslik – Cand. of Sci. (Med.), Associate Professor, Head of the Department of Ultrasonic and X-ray Surgical Methods of Diagnosis and Treatment
Sergey V. Bruslik – Cand. of Sci. (Med.), Associate Professor, Head of the Department of Ultrasonic and X-ray Surgical Methods of Diagnosis and Treatment
T. I. Sviridova
Pirogov National Medical Surgical Center of the Ministry of Health of Russia
Tatiyana I. Sviridova – Cand. of Sci. (Med.), Specialist for Ultrasound Diagnosis of the Department of Ultrasonic and X-ray Surgical Methods of Diagnosis and Treatment
For correspondence: “Ultrasound ablation”: Tatiyana I. Sviridova – 70, Nizhnyaya Pervomaiskaya str., Moscow, 105203. Phone: +7-499-464-30-43, +7-915-4-436-29-22.
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Review
For citations:
Vetshev P.S., Chzhao A.V., Ionkin D.A., Stepanova Yu.A., Zhavoronkova O.I., Kulezneva Yu.V., Melekhina O.V., Panchenkov D.N., Astakhov D.A., Ivanov Yu.V., Bruslik S.V., Sviridova T.I. Minimally invasive technologies for ablation of pancreatic malignancies. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2019;24(3):87-98. (In Russ.) https://doi.org/10.16931/1995-5464.2019387-98
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