Acinar cell cystadenoma of the pancreatic head
https://doi.org/10.16931/1995-5464.20202145-151
Abstract
Acinar cell cystadenoma is one of the rarest benign pancreatic tumors. A clinical case of acinar cell cystadenoma of the pancreatic head in a 67-year-old patient is presented. The tumor was detected during a routine examination. The patient was undergoing surgery, enucleation of the neoplasm was performed. With a planned histologic examination and immunohistochemical analysis the diagnosis was confirmed. Surgical tactics depend on the location, size of the tumor and position to the adjacent structures. Given the benign nature of tumor, preference should be given to organpreserving interventions.
About the Authors
A. V. ShabuninRussian Federation
Alexey V. Shabunin – Doct. of Sci. (Med.), Professor, Corresponding Member of the Russiаn Асаdemy of Sсienсes, Head of the Surgery Department, Russian Medical Academy of Continuous Professional Education, Chief of the Botkin City Clinical Hospital
5, 2-nd Botkinsky passage, Moscow, 125284,
2/1, Barrikadnaya str., Moscow, 125993
М. М. Tavobilov
Russian Federation
Mikhail M. Tavobilov – Doct. of Sci. (Med.), Associate Professor of the Surgery Department, Russian Medical Academy of Continuous Professional Education, Head of the Department of Liver and Pancreas Surgery, Botkin City Clinical Hospital
5, 2-nd Botkinsky passage, Moscow, 125284,
2/1, Barrikadnaya str., Moscow, 125993
A. A. Karpov
Russian Federation
Alexey A. Karpov – Cand. of Sci. (Med.), Surgeon, Department of Liver and Pancreas Surgery
5, 2-nd Botkinsky passage, Moscow, 125284
О. V. Paklina
Russian Federation
Oxana V. Paklina – Doct. of Sci. (Med.), Head of the Pathology Department
5, 2-nd Botkinsky passage, Moscow, 125284
G. R. Setdikova
Russian Federation
Galiya R. Setdikova – Cand. of Sci. (Med.), Pathologist, Department of Pathology
5, 2-nd Botkinsky passage, Moscow, 125284
N. A. Ivanova
Russian Federation
Natalya A. Ivanova – Ultrasound Physician
5, 2-nd Botkinsky passage, Moscow, 125284
D. S. Ozerova
Russian Federation
Darya S. Ozerova – Postgraduate Student of the Surgery Department
2/1, Barrikadnaya str., Moscow, 125993
References
1. Sigel C.S., Klimstra D.S. Cytomorphologic and immunophenotypical features of acinar cell neoplasms of the pancreas. Cancer Cytopathol. 2013; 121 (8): 459–470. https://doi.org/10.1002/cncy.21279
2. Albores-Saavedra J. Acinar cystadenoma of the pancreas: a previously undescribed tumor. Ann. Diagn. Pathol. 2002; 6 (2): 113–115.
3. Klimstra D.S., Hruban R.H., Koppel G., Morohoshi T., Ohike N. Acinar cell neoplasms of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, editors. WHO classification of tumors of the digestive system. Lyon: International Agency for Research on Cancer. 2010. P. 314–315.
4. Tanaka H., Hatsuno T., Kinoshita M., Hasegawa К., Ishihara Н., Takano N., Shimoyama S., Nakayama H., Kataoka M., Ichihara S., Kanda M., Kodera Y., Kondo K. A resected case of symptomatic acinar cell cystadenoma of the pancreas displacing the main pancreatic duct. Surg. Case Rep. 2016; 2 (1): 39. https://doi.org/10.1186/s40792-016-0166-1
5. Khor T.S., Badizadegan K., Ferrone C., Fernández-del Castillo C., Desai G.S., Saenz A., Le L., Lauwers G.Y., Deshpande V. Acinar cystadenoma of the pancreas: a clinicopathologic study of 10 cases including multilocular lesions with mural nodule. Am. J. Surg. Pathol. 2012; 36 (11): 1579–1591. https://doi.org/10.1097/PAS.0b013e318265fa4b
6. Mc Evoy M. P., Rich B., Klimstra D., Vakiani E., La Quaglia M.P. Acinar cell cystadenoma of the pancreas in a 9-year-old boy. J. Pediatr. Surg. 2010; 45 (5): 7–9. https://doi.org/10.1016/j.jpedsurg.2010.02.043
7. Cosgrove N., DiPalma J., Katz D., Kowalski T. A Rare case of acinar cell cystadenoma in a 14-year-old adolescent. Case Rep. Pancreat. Cancer. 2016; 2 (1): 3–5. https://doi.org/10.1089/crpc.2015.29009
8. Vinogradov I.U., Artemieva A.S., Vinogradov I.I. Pancreatic acinar cell adenoma. Archive of Pathology = Arkhiv Patologii. 2012; 74 (4): 46–48. (In Russian)
9. Couvelard A., Terris B., Hammel P., Palazzo L., Belghiti J., Lévy P., Ruszniewski P., Degott C. Acinar cystic transfor mation of the pancreas (or acinar cell cystadenoma), a rare and recently described entity. Ann. Pathol. 2002; 22 (5): 397–400.
10. Zhong N., Zhang L., Takahashi N., Shalmiyev V., Canto M., Clain J., Deutsch J., DeWitt J., Eloubeidi M., Gleeson F., Levy M., Mallery S., Raimondo M., Rajan E., Stevens T., Topazian M. Histologic and imaging features of mural nodules in mucinous pancreatic cysts. Clin. Gastroenterol. Hepatol. 2012; 10 (2): 192–198. https://doi.org/10.1016/j.cgh.2011.09.029
11. Sahani D.V., Kadavigere R., Saokar A., Fernandez-del Castillo C., Brugge W.R., Hahn P.F. Cystic pancreatic lesions: a simple imaging-based classification system for guiding management. Radiographics. 2005; 25 (6): 1471–1484.
12. Acar M., Tatli S. Cystic tumors of the pancreas: a radiological perspective. Diagn. Interv. 2011; 17 (2): 143–149. https://doi.org/10.4261/1305-3825.DIR.3254-09.1
13. Gumus M., Ugras S., Algin O., Gundogdu H. Acinar cell cystadenoma (acinar cystic transformation) of the pancreas: the radiologic-pathologic features. Korean J. Radiol. 2011; 12 (1): 129–134. https://doi.org/10.3348/kjr.2011.12.1.129
14. Delavaud C., d'Assignies G., Cros J., Ruszniewski P., Hammel P., Levy P., Couvelard A., Dokmak S., Vilgrain V., Vullierme M.P. CT and MR imaging of multilocular acinar cell cystadenoma: comparison with branch duct intraductal papillary mucinous neoplasia (IPMNs) Sauvanet A. Eur. Radiol. 2014; 24 (9): 2128–2136. https://doi.org/10.1007/s00330-014-3248-0
15. Sahani D., Prasad S., Saini S., Mueller P. Cystic pancreatic neoplasms evaluation by CT and magnetic resonance cholangiopan-creatography. Gastrointest. Endosc. Clin. N. Am. 2002; 12 (4): 657–672.
Review
For citations:
Shabunin A.V., Tavobilov М.М., Karpov A.A., Paklina О.V., Setdikova G.R., Ivanova N.A., Ozerova D.S. Acinar cell cystadenoma of the pancreatic head. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2020;25(2):145-151. (In Russ.) https://doi.org/10.16931/1995-5464.20202145-151