Radiofrequency ablation of intrahepatic cholangiocarcinoma (clinical observation)
https://doi.org/10.16931/1995-5464.20203142-148
Abstract
Intrahepatic cholangiocarcinoma is the primary adenocarcinoma of the intrahepatic bile ducts and the second most common liver tumor. Liver resection remains the most effective treatment. However, the possibilities of surgical treatment may be limited by the unresectability of the tumor and the inoperability of the patient due to concomitant diseases.
It is known that radiofrequency ablation is effective in the treatment of hepatocellular carcinoma and metastases of colorectal cancer in the liver, however, only a few clinical observations have been reported regarding its effectiveness in intrahepatic cholangiocarcinoma.
The accumulation of experience regarding the effectiveness of local destruction methods in intrahepatic cholangiocarcinoma especially in inoperable patients is of clinical value.
The accumulation of experience with local destruction methods in intrahepatic cholangiocarcinoma, especially in inoperable patients, is of clinical value.
This clinical observation presents the result of effective treatment of a patient with intrahepatic cholangiocarcinoma with cirrhosis using radiofrequency ablation. Relapse-free survival in this case was 44 months.
About the Authors
B. N. GurmikovRussian Federation
Beslan N. Gurmikov - Cand. of Sci. (Med.), Associate Professor, Surgeon of the Oncology Department of the Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russia.
27, Bolshaya Serpukhovskaya str., Moscow, 117997.
Phone: 9-963-171-57-34
O. I. Zhavoronkova
Russian Federation
Olga I. Zhavoronkova - Specialists of Ultrasound Diagnostics of the Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russia.
27, Bolshaya Serpukhovskaya str., Moscow, 117997.
Yu. A. Stepanova
Russian Federation
Yulia A. Stepanova - Doct. of Sci. (Med.), Professor, Scientific Secretary of the Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russia.
27, Bolshaya Serpukhovskaya str., Moscow, 117997.
V. A. Vishnevsky
Russian Federation
Vladimir A. Vishnevsky - Doct. of Sci. (Med.), Professor of the Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russia.
27, Bolshaya Serpukhovskaya str., Moscow, 117997.
A. V. Chzhao
Russian Federation
Alexey V. Chzhao - Doct. of Sci. (Med.), Professor, Deputy of Director of the Vishnevsky National Medical Research Center of Surgery of the Ministry of Health of Russia.
27, Bolshaya Serpukhovskaya str., Moscow, 117997.
References
1. Buettner S., van Vugt J.L., Ijzermans J.N., Groot Koerkamp B. Intrahepatic cholangiocarcinoma: current perspectives. Onco Targets Ther. 2017; 10: 1131-1142. https://doi.org/10.2147/OTT.S93629
2. Park J., Kim M.H., Kim K.P., Park D.H., Moon S.H., Song T.J., Eum J., Lee S.S., Seo D.W., Lee S.K. Natural history and prognostic factors of advanced cholangiocarcinoma without surgery, chemotherapy, or radiotherapy: a large-scale observational study. Gut Liver. 2009; 3 (4): 298-305. https://doi.org/10.5009/gnl.2009.3.4.298
3. Jarnagin W.R., Shoup M. Surgical management of cholangio-carcinoma. Sem in Liver Dis. 2004; 24 (2): 189-199. https://doi.org/10.1055/s-2004-828895
4. Ionkin D.A., Vishnevskiy V.A., Zhavoronkova O.I., Shura-kova A.B., Chzhao A.V. Radiofrequency ablation of colorectal metastases in liver. High-tech medicine = Vysokotekhnologicheskaya meditsina. 2014; 2: 17-37. (In Russian). http://hightechsurgery.ru/download/journal-htm/journal-htm-01-12-2014.pdf
5. Butros S.R., Shenoy-Bhangle A., Mueller P.R., Arellano R.S. Radiofre-quency ablation of intrahepatic cholangiocarcinoma: feasability, local tumor control, and long-term outcome. Clin. Imaging. 2014; 38 (4): 490-494. https://doi.org/10.1016/j.clinimag.2014.01.013
6. Shindoh J. Ablative therapies for intrahepatic cholangio-carcinoma. HepatoBiliary Surg. Nutr. 2017; 6 (1): 2-6. https://doi.org/10.21037/hbsn.2016.09.07
7. Spolverato G., Kim Y., Alexandrescu S., Marques H.P., Lamelas J., Aldrighetti L., Clark Gamblin T., Maithel S.K., Pulitano C., Bauer T.W., Shen F., Poultsides G.A., Tran T.B., Wallis Marsh J., Pawlik T.M. Management and outcomes of patients with recurrent intrahepatic cholangiocarcinoma following previous curative-intent surgical resection. Ann. Surg. Oncol. 2016; 23 (1): 235-243. https://doi.org/10.1245/s10434-015-4642-9
8. Tiong L., Maddern G.J. Systematic review and meta-analysis of survival and disease recurrence after radiofrequency ablation for hepatocellular carcinoma. Br. J. Surg. 2011; 98 (9): 12101224. https://doi.org/10.1002/bjs.7669
9. Simo K.A., Halpin L.E., McBrier N.M., Marques H.P., Lamelas J., Aldrighetti L., Clark Gamblin T., Maithel S.K., Pulitano C., Bauer T.W., Shen F., Poultsides G.A., Tran T.B., Wallis Marsh J., Pawlik T.M. Multimodality treatment of intrahepatic cholangiocarcinoma: A review. J. Surg. Oncol. 2016; 113 (1): 62-83. https://doi.org/10.1002/jso.24093.
10. Chiou Y.Y., Hwang J.I., Chou Y.H., Wang H-K., Chiang J.-H., Chang Ch.-Y. Percutaneous ultrasound-guided radiofrequency ablation of intrahepatic cholangiocarcinoma. Kaohsiung J. Med. Sci. 2005; 21 (7): 304-309. https://doi.org/10.1259/bjr/24563774
11. Carrafiello G., Lagana' D., Cotta E., Mangini M., Fontana F., Bandiera F., Fugazzola C. Radiofrequency ablation of intra-hepatic cholangiocarcinoma: preliminary experience. Cardiovasc. Intervent. Radiol. 2010; 33 (4): 835-839. https://doi.org/10.1007/s00270-010-9849-3.
12. Kamphues C., Seehofer D., Eisele R.M., Pratschke J., Neumann U.P., Neuhaus P. Recurrent intrahepatic cholangio-carcinoma: single-center experience using repeated hepatectomy and radiofrequency ablation. J. Hepatobiliary Pancreat. Sci. 2010; 17 (4): 509-515. https://doi.org/10.1007/s00534-009-0256-6
13. Kim J.H., Won H.J., Shin Y.M., Kim K.A., Kim P.N. Radiofrequency ablation for the treatment of primary intrahepatic cholangiocarcinoma. Am. J. Roentgenol. 2011; 196 (2): 205-209. https://doi.org/10.2214/AJR.10.4937.
14. Giorgio A., Calisti G., DE Stefano G., Farella N., Di Sarno A., Amendola F., Scognamiglio U., Giorgio V. Radiofrequency ablation for intrahepatic cholangiocarcinoma: retrospective analysis of a single centre experience. Anticancer Res. 2011; 31 (12): 4575-4580.
15. Kim J.H., Won H.J., Shin Y.M., Kim P.N., Lee S.G., Hwang S. Radiofrequency ablation for recurrent intrahepatic cholangio-carcinoma after curative resection. Eur. J. Radiol. 2011; 80 (3): e221-225. https://doi.org/10.1016/j.ejrad.2010.09.019
16. Yu M.A., Liang P., Yu X.L., Cheng Z.G., Han Z.Y., Liu F.Y., Yu J. Sonography-guided percutaneous microwave ablation of intrahepatic primary cholangiocarcinoma. Eur. J. Radiol. 2011; 80 (2): 548-552. https://doi.org/10.1259/bjr/24563774
17. Xu H.X., Wang Y., Lu M.D., Liu L.N. Percutaneous ultrasound-guided thermal ablation for intrahepatic cholangio-carcinoma. Br. J. Radiol. 2012; 85 (1016): 1078-1084. https://doi.org/10.1259/bjr/24563774
18. Fu Y., Yang W., Wu W., Yan K., Xing B.C., Chen M.H. Radiofrequency ablation in the management of unresectable intrahepatic cholangiocarcinoma. J. Vasc. Interv. Radiol. 2012; 23 (5): 642-649. https://doi.org/10.1016/j.jvir.2012.01.081
19. Haidu M., Dobrozemsky G., Schullian P., Widmann G., Klaus A., Weiss H., Margreiter R., Bale R. Stereotactic radiofrequency ablation of unresectable intrahepatic cholangio-carcinomas: a retrospective study. Cardiovasc. Intervent. Radiol. 2012; 35 (3): 1074-1082. https://doi.org/10.1007/s00270-011-0288-6
20. Zhang S.J., Hu P., Wang N., Shen Q., Sun A.X., Kuang M., Qian G.J. Thermal ablation versus repeated hepatic resection for recurrent intrahepatic cholangiocarcinoma. Ann. Surg. Oncol. 2013; 20 (11): 3596-3602. https://doi.org/10.1245/s10434-013-3035-1
21. Vogl T.J., Schwarz W., Eichler K., Hochmuth K., Hammer-stingl R., Jacob U., Scheller A., Zangos S., Heller M. Hepatic intraarterial chemotherapy with gemcitabine in patients with unresectable cholangiocarcinomas and liver metastases of pancreatic cancer: a clinical study on maximum tolerable dose and treatment efficacy. J. Cancer Res. Clin. Oncol. 2006; 132 (11): 745-755. https://doi.org/10.1007/s00432-006-0138-0
22. Burger I., Hong K., Schulick R., Georgiades C., Thuluvath P., Choti M., Kamel I., Geschwind J.F. Transcatheter arterial chemoembolization in unresectable cholangiocarcinoma: initial experience in a single institution. J. Vasc. Interv. Radiol. 2005; 16 (3): 353-361. https://doi.org/10.1097/01.RVI.0000143768.60751.78
23. Kiefer M.V., Albert M., McNally M., Robertson M., Sun W., Fraker D., Olthoff K., Christians K., Pappas S., Rilling W., Soulen M.C. Chemoembolization of intrahepatic cholangio-carcinoma with cisplatinum, doxorubicin, mitomycin C, ethiodol, and polyvinyl alcohol: a 2-center study. Cancer. 2011; 117 (7): 1498-1505. https://doi.org/10.1002/cncr.25625
24. Amini N., Ejaz A., Spolverato G., Kim Y., Herman J.M., Pawlik T.M. Temporal trends in liver-directed therapy of patients with intrahepatic cholangiocarcinoma in the United States: a population based analysis. J. Surg. Oncol. 2014; 110 (2): 163-170. https://doi.org/10.2147/OTT.S93629
25. Han K., Ko H.K., Kim K.W., Won H.J., Shin Y.M., Kim P.N. Radiofrequency ablation in the treatment of unresectable intrahepatic cholangiocarcinoma: systematic review and meta-analysis. JVIR. 2015; 26 (7): 943-948. https://doi.org/10.2214/AJR.10.4937
Review
For citations:
Gurmikov B.N., Zhavoronkova O.I., Stepanova Yu.A., Vishnevsky V.A., Chzhao A.V. Radiofrequency ablation of intrahepatic cholangiocarcinoma (clinical observation). Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2020;25(3):142-148. (In Russ.) https://doi.org/10.16931/1995-5464.20203142-148