Systemic therapy of hepatocellular carcinoma: reality and prospects
https://doi.org/10.16931/1995-5464.2020227-38
Abstract
This article discusses the results of clinical trials and the perspectives for perioperative systemic therapy for liver cancer, as well as the effectiveness of combination with locoregional methods. Special attention is paid to first and second line hepatocellular carcinoma therapy, as already approved in the Russian Federation (multikinase inhibitors, monoclonal antibodies to the vascular endothelial growth factor receptor, checkpoint inhibitors), as well as ongoing clinical trials. Promising combinations of immunotherapy with multikinase and (or) angiogenic inhibitors, potential predictors of the effectiveness of immunotherapy for hepatocellular carcinoma, as well as the features of therapy after orthotopic liver transplantation and against the background of non-compensated liver cirrhosis, are considered.
About the Authors
V. V. Breder
Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Valeriy V. Breder – Doct. of Sci. (Med.), Leading Researcher, Department of Chemotherapy No. 17
24, Kashirskoe shosse, Moscow, 115478
M. V. Natrusova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Maria V. Natrusova – Student of the Faculty of Fundamental Medicine
1, Leninskie Gory, Moscow,119991
I. A. Dzhanyan
Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Irina A. Dzhanyan – Surgeon, Department of Chemotherapy No. 17
24, Kashirskoe shosse, Moscow, 115478
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Breder V.V., Natrusova M.V., Dzhanyan I.A. Systemic therapy of hepatocellular carcinoma: reality and prospects. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2020;25(2):27-38. (In Russ.) https://doi.org/10.16931/1995-5464.2020227-38
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