Prediction and prevention of severe complications following radical surgical treatment of hilar cholangiocarcinoma
https://doi.org/10.16931/1995-5464.2022-1-64-71
Abstract
This literature review highlights the recent advances in the prevention and prognosis of purulent-septic complications, post-resection liver failure, and other severe postoperative complications following the surgical treatment of hilar cholangiocarcinoma. The data obtained from the analysis of the recent scientific publications indicate the relevance of this problem. Research should be prioritized to formulate combined methods that can assess the risk of perioperative complications.
About the Authors
E. N. Zamanov
Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies, Federal Medical Biological Agency of Russia
Russian Federation
Russian Federation
Ekhtibar N. Zamanov – MD, Surgeon, Department of Surgery No. 1, Federal Scientific and Clinical Center
28, Orekhovy bulvar, 115682, Moscow
M. G. Efanov
A.S. Loginov Moscow Clinical Scientific Center, Moscow Healthcare Department
Russian Federation
Russian Federation
Mikhail G. Efanov – Doct. of Sci. (Med.), Head of the Department of Hepatopancreatobiliary Surgery
86, Shosse Entuziastov, 111123
References
1. Vishnevskij V.A., Kovalenko Yu.A., Andrejceva O.I., Ikramov R.Z., Efanov M.G., Nazarenko N.A., Tupikin K.A. Postresection liver failure: modern problems of definition, epidemiology, pathogenesis, risk factors assessment, prevention and treatment. Ukraininan Journal of Surgery. 2013; (3): 172- 182. (In Russian)
2. Coelen R.J., Olthof P.B., van Dieren S., Besselink M.G., Busch O.R., van Gulik T.M. External validation of the estimation of physiologic ability and surgical stress (E-PASS) risk model to predict operative risk in perihilar cholangiocarcinoma. JAMA Surg. 2016; 151 (12): 1132-1138. https://doi.org/10.1001/jamasurg.2016.2305
3. Ito F., Cho C.S., Rikkers L.F., Weber S.M. Hilar cholangiocarcinoma: current management. Ann. Surg. 2009; 250 (2): 210-218. https://doi.org/10.1097/sla.0b013e3181afe0ab
4. Wiggers J.K., Groot Koerkamp B., Cieslak K.P., Doussot A., van Klaveren D., Allen P.J. Postoperative mortality after liver resection for perihilar cholangiocarcinoma: development of a risk score and importance of biliary drainage of the future liver remnant. J. Am. Coll. Surg. 2016; 223 (2): 321-331e1. https://doi.org/10.1016/j.jamcollsurg.2016.03.035
5. Liu Y., Wang J.Y., Jiang W. An increasing prominent disease of Klebsiella pneumoniae liver abscess: etiology, diagnosis, and treatment. Gastroenterol. Res. Pract. 2013; 2013: 258514. https://doi.org/10.1155/2013/258514
6. Olthof P.B., Wiggers J.K., Groot Koerkamp B., Coelen R.J., Allen P.J., Besselink M.G., Busch O.R., D'Angelica M.I., DeMatteo R.P., Kingham T.P., van Lienden K.P., Jarnagin W.R., van Gulik T.M. Postoperative liver failure risk score: identifying patients with resectable perihilar cholangiocarcinoma who can benefit from portal vein embolization. J. Am. Coll. Surg. 2017; 225 (3): 387-394. https://doi.org/10.1016/j.jamcollsurg.2017.06.007
7. Lee F., Ohanian E., Rheem J., Laine L., Che K., Kim J.J. Delayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis. Aliment. Pharmacol. Ther. 2015; 42 (2): 212-220. https://doi.org/10.1111/apt.13253
8. Lee J.G. Diagnosis and management of acute cholangitis. Nat. Rev. Gastroenterol. Hepatol. 2009; 6 (9): 533-541. https://doi.org/10.1038/nrgastro.2009.126
9. Mosler P. Diagnosis and management of acute cholangitis. Curr. Gastroenterol. Rep. 2011; 13 (2): 166-172. https://doi.org/10.1007/s11894-010-0171-7
10. Nagino M., Hirano S., Yoshitomi H., Aoki T., Uesaka K., Unno M., Ebata T., Konishi M., Sano K., Shimada K., Shimizu H., Higuchi R., Wakai T., Isayama H., Okusaka T., Tsuyuguchi T., Hirooka Y., Furuse J., Maguchi H., Suzuki K., Yamazaki H., Kijima H., Yanagisawa A., Yoshida M., Yokoyama Y., Mizuno T., Endo I. Clinical practice guidelines for the management of biliary tract cancers 2019: The 3rd English edition. J. Hepatobiliary Pancreat. Sci. 2021; 28 (1): 26-54. https://doi.org/10.1002/jhbp.870
11. Wiggers J.K., Groot Koerkamp B., Coelen R.J., Doussot A., van Dieren S., Rauws E.A., Schattner M.A., van Lienden K.P., Brown K.T., Besselink M.G., van Tienhoven G., Allen P.J., Busch O.R., D'Angelica M.I., DeMatteo R.P., Gouma D.J., Kingham T.P., Verheij J., Jarnagin W.R., van Gulik T.M. Percutaneous preoperative biliary drainage for resectable perihilar cholangiocarcinoma: no association with survival and no increase in seeding metastases. Ann. Surg. Oncol. 2015; 22 (Suppl. 3): S1156-1163. https://doi.org/10.1245/s10434-015-4676-z
12. Zhang X.F., Beal E.W., Merath K., Ethun C.G., Salem A., Weber S.M., Tran T., Poultsides G., Son A.Y., Hatzaras I., Jin L., Fields R.C., Weiss M., Scoggins C., Martin R.C.G., Isom C.A., Idrees K., Mogal H.D., Shen P., Maithel S.K., Schmidt C.R., Pawlik T.M.J. Oncologic effects of preoperative biliary drainage in resectable hilar cholangiocarcinoma: percutaneous biliary drainage has no adverse effects on survival. Surg. Oncol. 2018; 117 (6): 1267-1277. https://doi.org/10.1002/jso.24945
13. Coelen R.J.S., Roos E., Wiggers J.K., Besselink M.G., Buis C.I., Busch O.R.C., Dejong C.H.C., van Delden O.M., van Eijck C.H.J., Fockens P., Gouma D.J., Koerkamp B.G., de Haan M.W., van Hooft J.E., Izermans J.N.M., Kater G.M., Koornstra J.J., van Lienden K.P., Moelker A., Damink S.W.M.O., Poley J.W., Porte R.J., de Ridder R.J., Verheij J., van Woerden V., Rauws E.A.J., Dijkgraaf M.G.W., van Gulik T.M. Endoscopic versus percutaneous biliary drainage in patients with resectable perihilar cholangiocarcinoma: a multicentre, randomised controlled trial. Lancet Gastroenterol. Hepatol. 2018; 3 (10): 681-690. https://doi.org/10.1016/S2468-1253(18)30234-6
14. Tang Z., Yang Y., Meng W., Li X. Best option for preoperative biliary drainage in Klatskin tumor: a systematic review and metaanalysis. Medicine (Baltimore). 2017; 96 (43): e8372. https://doi.org/10.1097/MD.0000000000008372
15. Liu J.G., Wu J., Wang J., Shu G.M., Wang Y.J., Lou C., Zhang J., Du Z. Endoscopic biliary drainage versus percutaneous transhepatic biliary drainage in patients with resectable hilar cholangiocarcinoma: a systematic review and meta-analysis. J. Laparoendosc. Adv. Surg. Tech. A. 2018; 28 (9): 1053-1060. https://doi.org/10.1089/lap.2017.0744
16. Khat’kov I.E., Avanesyan R.G., Akhaladze G.G., Beburishvili A.G., Bulanov A.Yu., Bykov M.I., Virshke E.G., Gabri l' S.A., Granov D.A., Darvin V.V., Dolgushin B.I., Dyuzheva T.G., Efanov M.G., Korobko V.L., Korolev M.P., Kulabukhov V.V., Maistrenko N.A., Melekhina O.V., Nedoluzhko I.Iu., Okhotnikov O.I., Pogrebnyakov V.Yu., Polikarpov A.A., Prudkov M.I., Ratnikov V.A., Solodinina E.N., Stepanova Yu.A., Subbotin V.V., Fedorov E.D., Shabunin A.V., Shapoval’yants S.G., Shulutko A.M., Shishin K.V., Tsvirkun V.N., Chzhao A.V., Kulezneva Iu.V. Russian consensus on current issues in the diagnosis and treatment of obstructive jaundice syndrome. Pirogov Russian Journal of Surgery = Khirurgiya. Zhurnal im. N.I. Pirogova. 2020; 6: 5-17. https://doi.org/10.17116/hirurgia20200615
17. Nimura Y. Preoperative biliary drainage before resection for cholangiocarcinoma (Pro). HPB. 2008; 10 (2): 130-133. https://doi.org/10.1080/13651820801992666
18. Neuhaus P., Jonas S., Bechstein W.O., Lohmann R., Radke C., Kling N., Wex C., Lobeck H., Hintze R. Extended resections for hilar cholangiocarcinoma. Ann. Surg. 1999; 230 (6): 808-819. https://doi.org/10.1097/00000658-199912000-00010
19. Ferrero A., Lo Tesoriere R., Viganò L., Caggiano L., Sgotto E., Capussotti L. Preoperative biliary drainage increases infectious complications after hepatectomy for proximal bile duct tumor obstruction. World J. Surg. 2009; 33 (2): 318-325. https://doi.org/10.1007/s00268-008-9830-3
20. Vishnevskij V.A., Efanov M.G., Ikramov R.Z., Nazarenko N.A., Shevchenko T.V., Ionkin D.A., Chzhao A.V. Long-term results after R0 and R1 resections in patients with hilar cholangiocarcinoma. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2013; 18 (2): 9-20. (In Russian)
21. Vauthey J.N., Pawlik T.M., Abdalla E.K., Arens J.F., Nemr R.A., Wei S.H. Is extended hepatectomy for hepatobiliary malignancy justified? Ann. Surg. 2004; 239 (5): 722-730. https://doi.org/10.1097/01.sla.0000124385.83887.d5
22. Balzan S., Belghiti J., Farges O., Ogata S., Sauvanet A., Delefosse D., Durand F. The “50-50 criteria” on postoperativeday 5: an accurate predictor of liver failure and death after hepatectomy. Ann. Surg. 2005; 242 (6): 824-828. https://doi.org/10.1097/01.sla.0000189131.90876.9e
23. Rahbari N.N., Garden O.J., Padbury R., Brooke-Smith M., Crawford M., Adam R., Koch M., Makuuchi M., Dematteo R.P., Christophi C., Banting S., Usatoff V., Nagino M., Maddern G., Hugh T.J., Vauthey J.N., Greig P., Rees M., Yokoyama Y., Fan S.T., Nimura Y., Figueras J., Capussotti L., Büchler M.W., Weitz J. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011; 149 (5): 713-724. https://doi.org/10.1016/j.surg.2010.10.001
24. Garcea G., Ong S.L., Maddern G.J. Predicting liver failure following major hepatectomy. Dig. Liver Dis. 2009; 41 (11): 798-806. https://doi.org/10.1016/j.dld.2009.01.015
25. Golse N., Bucur P.O., Adam R., Castaing D., Sa Cunha A., Vibert E. New paradigms in post-hepatectomy liver failure. J. Gastrointest. Surg. 2013; 17 (3): 593-605. https://doi.org/10.1007/s11605-012-2048-6
26. Higuchi R., Yamamoto M. Indications for portal vein embolization in perihilar cholangiocarcinoma. J. Hepatobiliary Pancreat. Sci. 2014; 21 (8): 542-549. https://doi.org/10.1002/jhbp.77
27. Palavecino M., Abdalla E.K., Madoff D.C., Vauthey J.N. Portal vein embolization in hilar cholangiocarcinoma. Surg. Oncol. Clin. N. Am. 2009; 18 (2): 257-267. https://doi.org/10.1016/j.soc.2008.12.007
28. Eshmuminov D., Raptis D.A., Linecker M., Wirsching A., Lesurtel M., Clavien P.-A. Meta-analysis of associating liver partition with portal vein ligation and portal vein occlusion for two-stage hepatectomy. Br. J. Surg. 2016; 103 (13): 1768-1782. https://doi.org/10.1002/bjs.10290
29. Abdel-Aziz T.M.E. Novel therapeutic strategies for prevention of postresectional liver failure: dis. UCL (University College London), 2012. 206 p.
30. Dhir M., Smith L.M., Ullrich F., Leiphrakpam P.D., Ly Q.P., Sasson A.R., Are C. Pre-operative nomogram to predict risk of peri-operative mortality following liver resections for malignancy. J. Gastrointest. Surg. 2010; 14 (11): 1770-1781. https://doi.org/10.1007/s11605-010-1352-2
31. Tupikin K.A., Kovalenko Yu.A., Vishnevskii V.A. Novye vozmozhnosti prognozirovaniya postrezektsionnoi pechenochnoi nedostatochnosti. Annaly khirurgicheskoi gepatologii. 2016; 21 (3): 70-74. https://doi.org/10.16931/1995-5464.2016370-74 Tupikin K.A., Kovalenko Yu.A., Vishnevsky V.A. New options in prediction of post-resection liver failure. Annaly khirurgicheskoy gepatologi = Annals of HPB Surgery. 2016; 21 (3): 70-74. https://doi.org/10.16931/1995-5464.2016370-74 (In Russian)
32. Schnitzbauer A.A., Lang S.A., Goessmann H., Nadalin S., Baumgart J., Farkas S.A., Lang H., Obed A., Schlitt H.J. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling two:staged extended right hepatic resection in small:for:size settings. Ann. Surg. 2012; 255 (3): 405-414. https://doi.org/10.1097/SLA.0b013e31824856f5
33. Schadde E., Raptis D.A., Schnitzbauer A.A., Ardiles V., Tschuor C., Lesurtel M., Abdalla E.K., Hernandez-Alejandro R., Jovine E., Machado M., Malago M., Robles-Campos R., Petrowsky H., Santibanes E.D., Clavien P.A. Prediction of mortality after ALPPS stage-1: an analysis of 320 patients from the international ALPPS registry. Ann. Surg. 2015; 262 (5): 780-785. https://doi.org/10.1097/SLA.0000000000001450
34. Olthof P.B., Coelen R., Wiggers J.K., Groot Koerkamp B., Malago M., Hernandez-Alejandro R., Topp S.A., Vivarelli M., Aldrighetti L.A., Robles Campos R., Oldhafer K.J., Jarnagin W.R., van Gulik T.M. High mortality after ALPPS for perihilar cholangiocarcinoma: case-control analysis including the first series from the international ALPPS registry. HPB. 2016; 19 (5): 381-387. https://doi.org/10.1016/j.hpb.2016.10.008
35. Gall T.M.H., Sodergren M.H., Frampton A.E., Fan R., Spalding D.R., Habib N.A., Jiao L.R. Radio-frequency-assisted Liver Partition With Portal Vein Ligation (RALPP) for liver regeneration. Ann. Surg. 2015; 261 (2): e45-e46. https://doi.org/10.1097/sla.0000000000000607
36. Melekhina O.V., Kulezneva Yu.V., Efanov M.G., Alikhanov R.B, Kim P.P. Interventsionnaya radiologiya v etapnom lechenii patsientov s opukhol'yu Klatskina. Moskovskii klinicheskii nauchno-prakticheskii tsentr. [Elektronnyi resurs] http://vestnik.rncrr.ru/vestnik/v16/docs/section3/Melekhina. pdf. (data obrashcheniya 09.03.2021) Melekhina O.V., Kulezneva Yu.V., Efanov M.G., Alihanov R.B., Kim P.P. Intervencionnaya radiologiya v etapnom lechenii pacientov s opuhol'yu Klackina [Interventional radiology in the staged treatment of patients with Klatskin tumor] Moskovskij klinicheskij nauchno-prakticheskij centr. [Electronic resource]. http://vestnik.rncrr.ru/vestnik/v16/docs/section3/Melekhina. pdf. (In Russian) (date of access 09.03.2021)
37. Tanaka S., Hirohashi K., Tanaka H., Shuto T., Lee S.H., Kubo S., Takemura S., Yamamoto T., Uenishi T., Kinoshita H. Incidence and management of bile leakage after hepatic resection for malignant hepatic tumors. J. Am. Coll. Surg. 2018; 195 (4): 484-489. https://doi.org/10.1016/s1072-7515(02)01288-7
38. Dindo D., Demartines N., Clavien P.A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann. Surg. 2004; 240 (2): 205-213. https://doi.org/10.1097/01.sla.0000133083.54934.ae
39. Strasberg S.M., Linehan D.C., Hawkins W.G. The accordion severity grading system of surgical complications. Ann. Surg. 2009; 250 (2): 177-186. https://doi.org/10.1097/SLA.0b013e3181afde41
40. Kawamura T., Noji T., Okamura K., Tanaka K., Nakanishi Y., Asano T., Ebihara Y., Kurashima Y., Nakamura T., Murakami S., Tsuchikawa T., Shichinohe T., Hirano S. Postoperative liver failure criteria for predicting mortality after major hepatectomy with extrahepatic bile duct resection. Dig. Surg. 2019; 36 (2): 158-165. https://doi.org/10.1159/000486906
41. Nakanishi Y., Tsuchikawa T., Okamura K., Nakamura T., Tamoto E., Noji T., Asano T., Amano T., Shichinohe T., Hirano S. Risk factors for a high Comprehensive Complication Index score after major hepatectomy for biliary cancer: a study of 229 patients at a single institution. HPB (Oxford). 2016; 18 (9): 735-741. https://doi.org/10.1016/j.hpb.2016.06.013
42. Haga Y., Miyamoto A., Wada Y., Takami Y., Takeuchi H. Value of E-PASS models for predicting postoperative morbidity and mortality in resection of perihilar cholangiocarcinoma and gallbladder carcinoma. HPB. 2016; 18 (3): 271-278. https://doi.org/10.1016/j.hpb.2015.09.00
43. Wang H., Wang H., Chen T., Liang X., Song Y., Wang J. Evaluation of the POSSUM, P-POSSUM and E-PASS scores in the surgical treatment of hilar cholangiocarcinoma. World J. Surg. Oncol. 2014; 12 (1): 1-7. https://doi.org/10.1186/1477-7819
Review
For citations:
Zamanov E.N., Efanov M.G. Prediction and prevention of severe complications following radical surgical treatment of hilar cholangiocarcinoma. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2022;27(1):64-71. (In Russ.) https://doi.org/10.16931/1995-5464.2022-1-64-71
Views:
429
ISSN 1995-5464 (Print)
ISSN 2408-9524 (Online)
ISSN 2408-9524 (Online)
Email this article 