Association between heme oxygenase-1 (HMOX1) gene polymorphism and chronic pancreatitis
https://doi.org/10.16931/1995-5464.2022-1-56-63
Abstract
Aim: To investigate the association of the heme oxygenase-1 (HMOX1) gene polymorphism rs2071746 and chronic pancreatitis in the Azerbaijani population.
Methods: From a period of 2014–2019, 70 patients with different types of chronic pancreatitis and 90 apparently healthy volunteers were observed. Of them, 55 subjects were consuming alcohol at least 3–4 times a week, with an average daily dose of >80 g/L, and 35 subjects were not consuming alcohol. The venous blood samples were collected from the control subjects and patients with pancreatitis; DNA was extracted and analyzed by polymerase chain reaction–restriction fragment length polymorphism.
Results: The A allele in the homozygous form (A/A genotype) was found to be more common in patients with chronic pancreatitis (42.9%) than in the control group (16.6%). Thus, the A allele in the homozygous form (A/A genotype) may be associated with the development of chronic pancreatitis (odd ratio [OR] = 3.75; 95% confidence interval [CI] 1.81–7.77; p = 0.000). Furthermore, a statistical correlation between the A allele of the 495 A>T polymorphism (rs2071746) and an increased risk of the disease was observed. (p = 0.02, OR = 1.73; 95% CI 1.09–2.74). The heterozygous form of the A allele (A/T genotype; OR = 0.27; 95% CI = 0.13–0.56) and the T allele of the HMOX1 −495 A>T (rs2071746) polymorphism (OR = 0.53; 95% CI 0.32–0.89) reduced the risk of developing chronic alcoholic pancreatitis (p = 0.000 and p = 0.017, respectively).
Conclusion: The identification of genetic association of the various types of chronic pancreatitis will encourage further research on HMOX1, drug development, or the use of hemin in clinical practice.
About the Authors
G. R. Aliyeva
Scientific Center of Surgery Named After Acad. M.A. Topchibashov
Azerbaijan
Azerbaijan
Gunay R. Aliyeva – Cand. of Sci. (Med.), Researcher of the Department of Hepatobiliary Surgery
AZ1122 Sharifzadeh str., 196, Baku
G. F. Muslumov
Scientific Center of Surgery Named After Acad. M.A. Topchibashov
Azerbaijan
Azerbaijan
Gurbankhan F. Muslumov – Doct. of Sci. (Med.), Professor, Head of the Coloproctology Department of the Scientific Center
AZ1122 Sharifzadeh str., 196, Baku
B. I. Bayramov
Azerbaijan National Academy of Sciences, Genetic Resources Institute
Azerbaijan
Azerbaijan
Bayram I. Bayramov – Head of the Laboratory
AZ1106 Azadlig pr., 155, Baku
N. D. Zeynalov
Scientific Center of Surgery Named After Acad. M.A. Topchibashov
Azerbaijan
Azerbaijan
Natig J. Zeynalov – Junior Researcher of the Department of Gastrointestinal Surgery
AZ1122 Sharifzadeh str., 196, Baku
V. V. Behbudov
Scientific Center of Surgery Named After Acad. M.A. Topchibashov
Azerbaijan
Azerbaijan
Vugar V. Behbudov – Junior Researcher of the Department of Hepatobiliary Surgery
AZ1122 Sharifzadeh str., 196, Baku
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Aliyeva G.R., Muslumov G.F., Bayramov B.I., Zeynalov N.D., Behbudov V.V. Association between heme oxygenase-1 (HMOX1) gene polymorphism and chronic pancreatitis. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2022;27(1):56-63. (In Russ.) https://doi.org/10.16931/1995-5464.2022-1-56-63
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