Modern approaches to surgical treatment of patients with colorectal cancer liver metastases
https://doi.org/10.16931/1995-5464.2022-1-80-86
Abstract
Hepatic resection has become the treatment of choice for metastatic colorectal cancer, and this treatment technique increases the five-year survival of cancer patients up to 40–58%. More recently, the criteria for resectability have been revised and expanded to include any patient in whom all metastatic deposits can be removed with a negative surgical margin and with sufficient residual liver parenchyma. Currently, resectability is determined mostly by the minimum functional liver remnant volume. Under this new paradigm, the number of patients with potentially resectable oncological process can be increased. However, there are no widely accepted concepts and criteria for resectability, which further complicates the choice of treatment methods and directly affects the patients’ survival. The literature search for this review was performed using PubMed, Cochrane Library, Google Scholar, and eLibrary systems. We included publications that characterized the modern possibilities of liver surgery aimed at increasing resectability and improving cancer outcomes in patients with colorectal cancer liver metastases.
About the Authors
A. Y. Dobrodeev
Cancer Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences,Tomsk
Russian Federation
Russian Federation
Alexey Yu. Dobrodeev – Doct. of Sci. (Med.), Leading Researcher, Department of Abdominal Oncology
5, Kooperativny per., Tomsk, 634009
D. N. Kostromitsky
Cancer Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences,Tomsk
Russian Federation
Russian Federation
Dmitry N. Kostromitsky – Cand. of Sci. (Med.), Researcher, Department of Abdominal Oncology
5, Kooperativny per., Tomsk, 634009
S. G. Afanasyev
Cancer Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences,Tomsk
Russian Federation
Russian Federation
Sergey G. Afanasyev – Doct. of Sci. (Med.), Professor, Head of the Department of Abdominal Oncology
5, Kooperativny per., Tomsk, 634009
A. S. Tarasova
Cancer Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences,Tomsk
Russian Federation
Russian Federation
Anna S. Tarasova – Cand. of Sci. (Med.), Researcher, Department of Abdominal Oncology
5, Kooperativny per., Tomsk, 634009
A. V. Avgustinovich
Cancer Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences,Tomsk
Russian Federation
Russian Federation
Aleksandra V. Avgustinovich – Cand. of Sci. (Med.), Senior Researcher, Department of Abdominal Oncology
5, Kooperativny per., Tomsk, 634009
References
1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2020. CA Cancer J. Clin. 2020; 70 (1): 7–30. https://doi.org/10.3322/caac.21590
2. Adam R., De Gramont A., Figueras J., Guthrie A., Kokudo N., Kunstlinger F., Loyer E., Poston G., Rougier P., RubbiaBrandt L., Sobrero A., Tabernero J., Teh C., Van Cutsem E., Vauthey J.-N. of the EGOSLIM (Expert Group on OncoSurgery management of Liver Metastases) group. The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus. Oncologist. 2012; 17 (10): 1225–1239. https://doi.org/10.1634/theoncologist.2012-0121
3. Leporrier J., Maurel J., Chiche L., Bara S., Segol P., Launoy G. A population-based study of the incidence, management and prognosis of hepatic metastases from colorectal cancer. Br. J. Surg. 2006; 93 (4): 465–474. https://doi.org/10.1002/bjs.5278
4. Angelsen J.H., Viste A., Løes I.M., Eide G.E., Hoem D., Sorbye H., Horn A. Predictive factors for time to recurrence, treatment and post-recurrence survival in patients with initially resected colorectal liver metastases. World J. Surg. Oncol. 2015; 13: 328. https://doi.org/10.1186/s12957-015-0738-8
5. Rehman A.H., Jones R.P., Poston G. Prognostic and predictive markers in liver limited stage IV colorectal cancer. Eur. J. Surg. Oncol. 2019; 45 (12): 2251–2256. https://doi.org/10.1016/j.ejso.2019.06.038
6. Kyrgiou M., Kalliala I., Markozannes G., Gunter M.J., Paraskevaidis E., Gabra H., Martin-Hirsch P., Tsilidis K.K. Adiposity and cancer at major anatomical sites: umbrella review of the literature. BMJ. 2017; 356: j477. https://doi.org/10.1136/bmj.j477
7. Tsai M.S., Su Y.H., Ho M.C., Liang J.T., Chen T.P., Lai H.S., Lee P.H. Clinicopathological features and prognosis in resectable synchronous and metachronous colorectal liver metastasis. Ann. Surg. Oncol. 2007; 14 (2): 786–794. https://doi.org/10.1245/s10434-006-9215-5
8. Chow F.C., Chok K.S. Colorectal liver metastases: an update on multidisciplinary approach. World J. Hepatol. 2019; 11 (2): 150–172. https://doi.org/10.4254/wjh.v11.i2.150
9. Valdimarsson V.T., Syk I., Lindell G., Sandström P., Isaksson B., Rizell M., Norén A., Ardnor B., Sturesson C. Outcomes of simultaneous resections and classical strategy for synchronous colorectal liver metastases in Sweden: a nationwide study with special reference to major liver resections. World J. Surg. 2020; 44 (7): 2409–2417. https://doi.org/10.1007/s00268-020-05475-5
10. Kopetz S., Chang G.J., Overman M.J., Eng C., Sargent D.J., Larson D.W., Grothey A., Vauthey J.N., Nagorney D.M., McWilliams R.R. Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J. Clin. Oncol. 2009; 27 (22): 3677–3683. https://doi.org/10.1200/JCO.2008.20.5278
11. Torzilli G., Montorsi M., Donadon M., Palmisano A., Del Fabbro D., Gambetti A., Olivari N., Makuuchi M. “Radical but conservative” is the main goal for ultrasonographyguided liver resection: prospective validation of this approach. J. Am. Coll. Surg. 2005; 201 (4): 517–528. https://doi.org/10.1016/j.jamcollsurg.2005.04.026
12. Moris D., Ronnekleiv-Kelly S., Rahnemai-Azar A.A., Felekouras E., Dillhoff M., Schmidt C., Pawlik T.M. Parenchymalsparing versus anatomic liver resection for colorectal liver metastases: a systematic review. J. Gastrointest. Surg. 2017; 21 (6): 1076–1085. https://doi.org/10.1007/s11605-017-3397-y
13. Viganò L., Procopio F., Cimino M.M., Donadon M., Gatti A., Costa G., Del Fabbro D., Torzilli G. Is tumor detachment from vascular structures equivalent to R0 resection in surgery for colorectal liver metastases? An observational cohort. Ann. Surg. Oncol. 2016; 23 (4): 1352–1360. https://doi.org/10.1245/s10434-015-5009-y
14. Torzilli G., Procopio F., Cimino M., Donadon M., Fabbro D.D., Costa G., Garcia-Etienne C.A. Hepatic vein-sparing hepatectomy for multiple colorectal liver metastases at the caval confluence. Ann. Surg. Oncol. 2015; 22 (5): 1576. https://doi.org/10.1245/s10434-014-4189
15. Hosokawa I., Allard M.A., Mirza D.F., Kaiser G., Barroso E., Lapointe R., Laurent C., Ferrero A., Miyazaki M., Adam R. Outcomes of parenchyma-preserving hepatectomy and right hepatectomy for solitary small colorectal liver metastasis: a LiverMetSurvey study. Surgery. 2017; 162 (2): 223–232. https://doi.org/10.1016/j.surg.2017.02.012
16. Mentha G., Terraz S., Morel P., Andres A., Giostra E., Roth A., Rubbia-Brandt L., Majno P. Dangerous halo after neoadjuvant chemotherapy and two-step hepatectomy for colorectal liver metastases. Br. J. Surg. 2009; 96 (1): 95–103. https://doi.org/10.1002/bjs.6436
17. Tranchart H., Chirica M., Faron M., Balladur P., Lefevre L.B., Svrcek M., de Gramont A., Tiret E., Paye F. Prognostic impact of positive surgical margins after resection of colorectal cancer liver metastases: reappraisal in the era of modern chemotherapy. World J. Surg. 2013; 37 (11): 2647–2654. https://doi.org/10.1007/s00268-013-2186-3
18. Andreou A., Aloia T.A., Brouquet A., Dickson P.V., Zimmitti G., Maru D.M., Kopetz S., Loyer E.M., Curley S.A., Abdalla E.K., Vauthey J.N. Margin status remains an important determinant of survival after surgical resection of colorectal liver metastases in the era of modern chemotherapy. Ann. Surg. 2013; 257 (6): 1079–1088. https://doi.org/10.1097/SLA.0b013e318283a4d1
19. Saiura A., Yamamoto J., Hasegawa K., Koga R., Sakamoto Y., Hata S., Makuuchi M., Kokudo N. Liver resection for multiple colorectal liver metastases with surgery up-front approach: bi-institutional analysis of 736 consecutive cases. World J. Surg. 2012; 36 (9): 2171–2178. https://doi.org/10.1007/s00268-012-1616-y
20. Memeo R., de Blasi V., Adam R., Goéré D., Azoulay D., Ayav A., Gregoire E., Kianmanesh R., Navarro F., Sa Cunha A., Pessaux P.; French Colorectal Liver Metastases Working Group, Association Française de Chirurgie (AFC). Parenchymal-sparing hepatectomies (PSH) for bilobar colorectal liver metastases are associated with a lower morbidity and similar oncological results: a propensity score matching analysis. HPB (Oxford). 2016; 18 (9): 781–790. https://doi.org/10.1016/j.hpb.2016.06.004
21. Allard M.A., Adam R., Giuliante F., Lapointe R., Hubert C., Ijzermans J.N.M., Mirza D.F., Elias D., Laurent C., Gruenberger T., Poston G., Letoublon C., Isoniemi H., Lucidi V., Popescu I., Figuerasd J. Long-term outcomes of patients with 10 or more colorectal liver metastases. Br. J. Cancer. 2017; 117 (5): 604–611. https://doi.org/10.1038/bjc.2017.218
22. de Haas R.J., Wicherts D.A., Flores E., Azoulay D., Castaing D., Adam R. R1 resection by necessity for colorectal liver metastases: is it still a contraindication to surgery? Ann. Surg. 2008; 248 (4): 626–637. https://doi.org/10.1097/SLA.0b013e31818a07f1
23. Cady B., Jenkins R.L., Steele G.D. Jr., Lewis W.D., Stone M.D., McDermott W.V., Jessup J.M., Bothe A., Lalor P., Lovett E.J., Lavin P., Linehan D.C. Surgical margin in hepatic resection for colorectal metastasis: a critical and improvable determinant of outcome. Ann. Surg. 1998; 227 (4): 566–571. https://doi.org/10.1097/00000658-199804000-00019
24. Are C., Gonen M., Zazzali K., Dematteo R.P., Jarnagin W.R., Fong Y., Blumgart L.H., D'Angelica M. The impact of margins on outcome after hepatic resection for colorectal metastasis. Ann. Surg. 2007; 246 (2): 295–300. https://doi.org/10.1097/SLA.0b013e31811ea962
25. Nuzzo G., Giuliante F., Ardito F., Vellone M., Giovannini I., Federico B., Vecchio F.M. Influence of surgical margin on type of recurrence after liver resection for colorectal metastases: a single-center experience. Surgery. 2008; 143 (3): 384–393. https://doi.org/10.1016/j.surg.2007.09.038
26. Kokudo N., Miki Y., Sugai S., Yanagisawa A., Kato Y., Sakamoto Y., Yamamoto J., Yamaguchi T., Muto T., Makuuchi M. Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection. Arch. Surg. 2002; 137 (7): 833–840. https://doi.org/10.1001/archsurg.137.7.833
27. Pawlik T.M., Scoggins C.R., Zorzi D., Abdalla E.K., Andres A., Eng C., Curley S.A., Loyer E.M., Muratore A., Mentha G., Capussotti L., Vauthey J.N. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann. Surg. 2005; 241 (5): 715–722, discussion 722–724. https://doi.org/10.1097/01.sla.0000160703.75808.7d
28. Bodingbauer M., Tamandl D., Schmid K., Plank C., Schima W., Gruenberger T. Size of surgical margin does not influence recurrence rates after curative liver resection for colorectal cancer liver metastases. Br. J. Surg. 2007; 94 (9): 1133–1138. https://doi.org/10.1002/bjs.5762
Supplementary files
|
|
1. Сопроводительное письмо | |
| Subject | ||
| Type | Исследовательские инструменты | |
View
(649KB)
|
Indexing metadata ▾ | |
|
2. Редактированный вариант статьи (4500 знаков). Современные подходы к хирургическому лечению больных колоректальным раком с метастазами в печень: обзор литературы | |
| Subject | Современные подходы к хирургическому лечению больных колоректальным раком с метастазами в печень: обзор литературы | |
| Type | Материалы исследования | |
Download
(142KB)
|
Indexing metadata ▾ | |
Review
For citations:
Dobrodeev A.Y., Kostromitsky D.N., Afanasyev S.G., Tarasova A.S., Avgustinovich A.V. Modern approaches to surgical treatment of patients with colorectal cancer liver metastases. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2022;27(1):80-86. (In Russ.) https://doi.org/10.16931/1995-5464.2022-1-80-86
Views:
573
Email this article 