Morphological and ultrastructural changes in the common bile duct wall in stenting
A. V. Shabunin,
S. S. Lebedev,
I. A. Chekmareva,
O. A. Paklina,
M. M. Tavobilov,
A. A. Karpov,
P. A. Drozdov,
E. N. Gordienko https://doi.org/10.16931/1995-5464.2023-2-79-87
Abstract
Aim. To carry out a comprehensive morphological study into pathological changes in the common bile duct wall following various periods of plastic and nitinol stent implantation; to examine telocytes in the common bile duct wall. Materials and methods. The study involves the material of 91 patients, who underwent surgery for periampullary carcinoma from 2014 to 2020. Plastic stents were inserted in 56 cases, nitinol stents – in 35. The study of morphological structure of the common bile duct wall took into account the type of stent and period of its implantation (14–30 days, 31–60 days, ≥61 days).
Results. Inflammatory processes in patients with nitinol stent implantation have been revealed to prevail over fibroplastic processes, leading to hyperplasia of the common bile duct mucosa. Following plastic stents implantation, fibroplastic and atrophic changes prevailed. It was found that cases with plastic stent implantation are more often subject to damage to the telocyte ultrastructure and loss of intercellular connections.
Conclusion. Structural changes in telocytes can reflect the degree of fibrosis in the common bile duct wall depending on the type of stent.
About the Authors
A. V. Shabunin
Department of Surgery, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
Alexey V. Shabunin – Doct. of Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of Department; Chief Doctor
2/1 bld. 1, Barrikadnaya str., Moscow, 125993
5, 2nd Botkinsky pr., Moscow, 125284
S. S. Lebedev
Department of Surgery, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
Sergey S. Lebedev – Cand. of Sci. (Med.), Associate Professor; Head of Outpatient Cancer Care Center
2/1 bld. 1, Barrikadnaya str., Moscow, 125993
5, 2nd Botkinsky pr., Moscow, 125284
I. A. Chekmareva
A.V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Irina A. Chekmareva – Doct. of Sci. (Biol.), Head of Electron Microscopy Laboratory
27, Bol'shaya Serpukhovskaia str., Moscow, 117997
O. A. Paklina
S.P. Botkin City Clinical Hospital; A.V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Oksana V. Paklina – Doct. of Sci. (Med.), Head of Pathology Department; Chief Researcher, Electron Microscopy Laboratory
5, 2nd Botkinsky pr., Moscow, 125284
27, Bol'shaya Serpukhovskaia str., Moscow, 117997
M. M. Tavobilov
Department of Surgery, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
Mikhail M. Tavobilov – Doct. of Sci. (Med.), Professor; Head of Department of Liver and Pancreas Surgery
2/1 bld. 1, Barrikadnaya str., Moscow, 125993
5, 2nd Botkinsky pr., Moscow, 125284
A. A. Karpov
Department of Surgery, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
Alexey A. Karpov – Cand. of Sci. (Med.), Assistant; Surgeon, Department of Liver and Pancreas Surgery
2/1 bld. 1, Barrikadnaya str., Moscow, 125993
5, 2nd Botkinsky pr., Moscow, 125284
P. A. Drozdov
Department of Surgery, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation; S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
Pavel A. Drozdov – Cand. of Sci. (Med.), Assistant; Head of Department of Human Organ and Tissue Transplantation
2/1 bld. 1, Barrikadnaya str., Moscow, 125993
5, 2nd Botkinsky pr., Moscow, 125284
E. N. Gordienko
S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
Elena N. Gordienko – Cand. of Sci. (Med.), Junior Researcher, Pathologist, Pathology Department
5, 2nd Botkinsky pr., Moscow, 125284
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For citations:
Shabunin A.V., Lebedev S.S., Chekmareva I.A., Paklina O.A., Tavobilov M.M., Karpov A.A., Drozdov P.A., Gordienko E.N. Morphological and ultrastructural changes in the common bile duct wall in stenting. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2023;28(2):79-87. (In Russ.) https://doi.org/10.16931/1995-5464.2023-2-79-87
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