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Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery

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Сryosurgery for Liver Alveococcosis

https://doi.org/10.16931/1995-5464.2017411-17

Abstract

Aim. To determine the indications for cryotherapy and to evaluate its effectiveness in surgery for liver alveococcosis.
Material and Methods. 169 patients with liver alveococcosis were enrolled. Morphological study of liver specimens was carried out before and after cryotherapy to assess cold exposure on parasitic tissue.
Results. We have developed original devices which are protected by patents. They were used for radical (9) and palliative (25) liver resections, liver stump management after resection (43), marsupialization of the cavity with partially uninhabited parasitic tissue (62), cryodestruction of parasitic nodes and decay cavities (20), including in case of mechanical jaundice (14).
It is proved that cold exposure (−196 °C) leads to death of the germinal elements of the parasite, stops bleeding from vessels with diameter ≤ 1 mm and causes necrosis and sequestration of the parasitic nodes.
Conclusion. The use of cryoinstruments in liver resections for alveococcosis is aimed at preventing of recurrent disease and reduction of parenchymatous bleeding. Cryodestruction of parasitic nodes contributes to increase of life expectancy in inoperable patients.

About the Authors

N. V. Merzlikin
Siberian State Medical University of Healthcare Ministry of Russia
Russian Federation

Merzlikin Nikolay Vasilyevich – Doct. of Med. Sci., Professor, Head of the Department of Surgical Diseases with the Course of Traumatology and Orthopedics of the SSMU.

2, Moskovskiy trakt, Tomsk, 634050, Russian Federation



B. I. Alperovich
Siberian State Medical University of Healthcare Ministry of Russia
Russian Federation

Alperovich Boris Ilyich – Doct. of Med. Sci., Professor of the Department of Surgical Diseases with the Course of Traumatology and Orthopedics of the SSMU.

2, Moskovskiy trakt, Tomsk, 634050, Russian Federation


V. F. Tskhai
Siberian State Medical University of Healthcare Ministry of Russia
Russian Federation

Tskhay Valentina Fyodorovna – Doct. of Med. Sci., Professor of the Department of Surgical Diseases with the Course of Traumatology and Orthopedics of the SSMU.

2, Moskovskiy trakt, Tomsk, 634050, Russian Federation


N. A. Brazhnikova
Siberian State Medical University of Healthcare Ministry of Russia
Russian Federation

Brazhnikova Nadezhda Arkhipovna – Doct. of Med. Sci., Professor of the Department of Surgical Diseases with the Course of Traumatology and Orthopedics of the SSMU.

2, Moskovskiy trakt, Tomsk, 634050, Russian Federation


V. N. Salo
Siberian State Medical University of Healthcare Ministry of Russia
Russian Federation

Salo Vadim Nikolaevich – Doct. of Med. Sci., Professor of the Department of Surgical Diseases with the Course of Traumatology and Orthopedics of the SSMU.

2, Moskovskiy trakt, Tomsk, 634050, Russian Federation


I. S. Zaytsev
Alperovich City Clinical Hospital №3
Russian Federation

Zaytsev Ivan Sergeevich – Cand. of Med. Sci., Resident at the Surgical Department of Alperovich City Clinical Hospital №3.

3, Nakhimova str., Tomsk, 634045, Russian Federation



T. A. Noroeva
Siberian State Medical University of Healthcare Ministry of Russia
Russian Federation

Noroeva Tuyana Alekseevna – Student of the 5th Course of Pediatric Faculty of the SSMU.

2, Moskovskiy trakt, Tomsk, 634050, Russian Federation


А. S. Emelyanov
Siberian State Medical University of Healthcare Ministry of Russia
Russian Federation

Emelyanov Aleksey Sergeevich – Intern of the Department of Surgical Diseases with the Course of Traumatology and Orthopedics of the SSMU.

2, Moskovskiy trakt, Tomsk, 634050, Russian Federation


P. S. Bushlanov
Siberian State Medical University of Healthcare Ministry of Russia
Russian Federation

Bushlanov Pavel Sergeevich – Postgraduate Student of the Department of Surgical Disease with the Course of Traumatology and Orthopedics, SSMU, Russian Healthcare Ministry.

2, Moskovskiy trakt, Tomsk, 634050, Russian Federation


References

1. Shoykhet Ya.N., Kapitulin S.Yu., Fokeev S.D., Kazantseva E.S. Vliyanie rasprostranennosti al'veokokkoza pecheni na ob''yom khirurgicheskogo lechenia [An impact of the liver alveococcosis prevalence on the volume of surgical treatment]. Collection of materials of the XIX International Congress of surgeonshepatologists of Russia and CIS countries “Urgent problems of surgical hepatology”. Irkutsk, 2012. P. 97–98. (In Russian)

2. Bebezov Kh.S., Bebezov B.Kh., Mamashev N.D., Umetaliev T.M., Belekbaev T.M., Azhibekov S.Zh. Resultaty khirurgicheskogo lechenia oslozhnennogo al’veokokkoza pecheni [The results of surgical treatment of complicated liver alveococcosis]. Collection of materials of the XIX International Congress of surgeons-hepatologists of Russia and CIS countries “Urgent problems of surgical hepatology”. Irkutsk, 2012. P. 89. (In Russian)

3. Zhuravlev V.A., Rusinov V.M., Sukhorukov V.P., Buldakov V.V., Popyrin I.A., Yuzhanin V.B. Radical’noe lechenie al’veokokkoza s vovlecheniem magistral’nyh sosudov i nizhney poloj veny [Radical treatment of alveococcosis with involvement of great vessels and inferior vena cava]. Collection of materials of the XVII International Congress of surgeons-hepatologists of Russia and CIS countries “Urgent problems of surgical hepatology”. Ufa, 2010. P. 263–264. (In Russian)

4. Stadelmann B., Scholl S., Muller J., Hemphill A. Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes. J. Antimicrob. Chemother. 2010; 65 (3): 512–519. DOI: 10.1093//dkp490.

5. Milonov O.B., Knyazeva G.D., Kolos O.E., Minkina S.M., Rusa A.V. Cryotherapy in complex treatment of alveococcosis and echinococcosis. Khirurgia. 1975; 7: 66–70. (In Russian)

6. Rudakov V.A. Ochagovye porazhenia pecheni, diagnostika i lechenie [Focal liver lesions, diagnosis and treatment: dis. ... doct. med. sci.]. Tomsk, 1995. 329 p. (In Russian)

7. Salo V.N. Kriochirurgicheskie operacii na pecheni [Liver cryosurgery: dis. … cand. med. sci.]. Tomsk, 1991. 144 p. (In Russian)

8. Alperovich B.I. Khirurgia pecheni [Liver surgery]. Moscow: GEOTAR-Media, 2010. 352 p. (In Russian)

9. Merzlikin N.V., Alperovich B.I., Brazhnikova N.A. et al. Rukovodstvo po khirurgii ochagovyh parazitarnyh zabolevaniy pecheni [Manual for surgery of focal liver parasitic diseases]. Ed. by N.V. Merzlikin. Tomsk: Printing manufactory, 2015. 468 p. (In Russian)

10. Sorokin R.V. Khirurgicheskoe i kriokhirurgicheskoe lechenie recidivnogo ehinokokkoza i al’veokokkoza [Surgical and cryosurgical treatment of recurrent liver echinococcosis and alveococcosis: dis. ... cand. med. sci.]. Tomsk, 2007. 140 p. (In Russian)

11. Zaytsev I.S. Povtornye operacii pri al’veokokkoze [Redo surgery for alveococcosis: dis. … cand. med. sci.]. Tomsk, 2015. 150 p. (In Russian)

12. Tskhay V.F., Brazhnikova N.A., Alperovich B.I. et al. Parazitarnye mehanicheskie zheltuhi [Parasitic mechanical jaundice]. Tomsk: Siberian State Medical University, 2013. 230 p. (In Russian)


Review

For citations:


Merzlikin N.V., Alperovich B.I., Tskhai V.F., Brazhnikova N.A., Salo V.N., Zaytsev I.S., Noroeva T.A., Emelyanov А.S., Bushlanov P.S. Сryosurgery for Liver Alveococcosis. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2017;22(4):11-17. (In Russ.) https://doi.org/10.16931/1995-5464.2017411-17

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ISSN 1995-5464 (Print)
ISSN 2408-9524 (Online)