EVOLUTION OF TOPICAL DIAGNOSTIC ALGORITHM FOR PANCREATIC HORMONE-PRODUCING NEUROENDOCRINE TUMORS

Aim. To reflect the main approaches and trends in neuroendocrine tumors imaging.

Materials and Methods. 255 patients  with hormonally  active pancreatic  neuroendocrine tumors  were examined  and operated   for  the  period  1990–2015.  There  were  insulinomas  predominantly.  Sensitivity  of  ultrasonography,  CT, endoscopic ultrasound, arterial-stimulated blood sampling, IOUS was analyzed to reveal changes in diagnostic algorithm for this period.

Results. Multiple  pancreatic  lesions occurred  in 30%. Over the 25 years endosonography  as new “gold” standard  for pancreatic visualization was introduced. Indications for arterial-stimulated blood sampling were narrowed. However, this method is still actual and effective in the most difficult diagnostic situations.

Conclusion. Accurate  preoperative  topical  diagnosis  allows to  offer optimal,  organ-sparing  procedure  and  reduce intraoperative  trauma of the pancreas and number of postoperative complications.

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