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Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery

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THE EFFICIENCY OF STEREOTAXIC RADIOTHERAPY IN PATIENTS WITH LIVER METASTASES

https://doi.org/10.16931/1995-5464.2016138-43

Abstract

Aim. To determine the effectiveness of stereotaxic radiotherapy  in patients with liver metastases.

Material and Methods. Stereotaxic radiotherapy of liver metastatic tumors was carried out in three fractions for 5–8 days with single focal dose of 10, 12, 15, or 20 Gy. The procedure  was performed in 66 patients including 40 (60.5%) women and  26 (39.5%) men.  The  average age was 60 years (37–82). In  24 (36.5%) cases primary  tumor  was presented  by colorectal cancer, in 12 (18%) – breast cancer, in 7 (10.5%) – ovarian cancer and in 23 (35%) – other malignant tumors.

Results. Median  follow-up was 14.5 months  (range 1.8–53.5).  3 patients did not present data of control  examination. Among other 63 patients full effect was established in 16 (25.5%) cases, in 30 (47.5%) patients – partial regression of metastases,  in 11 (17.5%) – stabilization,  in 6 (9.5%) – progression of tumoral  process. Thus,  local control  rate was 90.5%. Degree III of radiation damage was reported in 2 cases (3%), II – in 7 cases (11%).

Conclusion. Stereotaxic  radiotherapy  seems highly effective and  safe method  of the  treatment of patients  with liver metastases and can be recommended for use in patients with limited liver metastases who have been denied in surgery.

About the Authors

S. I. Tkachev
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Tkachev Sergey Ivanovich – Doct.  of Med.  Sci.,  Professor,  Head  of the  Department of Radiation  Therapy.

24, Kashirskoye sh., Moscow, 115230


Yu. I. Patyutko
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Patyutko  Yury Ivanovich – Doct.  of Med. Sci., Professor, Head of the Department of  Liver and Pancreatic  Tumors.

24, Kashirskoye sh., Moscow, 115230


S. V. Medvedev
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Medvedev Sergey Vasilievich – Cand.  of Med. Sci., Senior Researcher  of the Department of Radiation  Therapy.

24, Kashirskoye sh., Moscow, 115230


D. S. Romanov
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Romanov Denis Sergeevich – Radiologist of the Department of Radiation  Therapy.

Apt. 578, 11, Starobitzevskaya str., Moscow,  117628, Phone: +7-962-919-03-22


I. V. Sagaydak
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Sagaydak Igor Vsevolodovich – Doct.  of Med. Sci., Professor,  Leading Researcher  of the Department of Liver and Pancreatic  Tumors.

24, Kashirskoye sh., Moscow, 115230


O. A. Zaspa
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Zaspa Oksana Andreevna – Researcher  of the Department of Pathological Anatomy.

24, Kashirskoye sh., Moscow, 115230


Yu. B. Bykova
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Bykova Yuliya Borisovna – Medical  Physicist,  Department of Radiation Topometry and Clinical Dosimetry.

24, Kashirskoye sh., Moscow, 115230


Yu. A. Gerasimov
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Gerasimov Yury Aleksandrovich – Radiologist  of  the  Department  of  Radiation  Therapy.

24, Kashirskoye sh., Moscow, 115230


D. V. Podluzhny
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Podluzhny Danil Viktorovich – Cand. of Med. Sci., Senior Researcher of the Department of Liver and Pancreatic  Tumors.

24, Kashirskoye sh., Moscow, 115230


А. D. Gakhramanov
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Gakhramanov Aly Dzhandarovich  – Cand. of Med. Sci., Researcher  of the Department of Liver and Pancreatic  Tumors.

24, Kashirskoye sh., Moscow, 115230


A. N. Polyakov
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Polyakov Aleksander Nikolaevich – Cand.  of Med. Sci., Researcher of the Department of Liver and Pancreatic  Tumors.

24, Kashirskoye sh., Moscow, 115230


T. V. Yurieva
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Yurieva Tatiana Vladimirovna – Cand. of Med. Sci., Head of the Department of Radiation  Topometry  and Clinical Dosimetry.

24, Kashirskoye sh., Moscow, 115230


R. A. Gutnik
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Gutnik Raisa Andreevna – Medical Physicist of the Department of Radiation Topometry and Clinical Dosimetry.

24, Kashirskoye sh., Moscow, 115230


A. V. Mikhailova
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Mikhailova Anna Vyacheslavovna – Medical Physicist of the Department of Radiation  Topometry  and Clinical  Dosimetry.

24, Kashirskoye sh., Moscow, 115230


I. P. Yazhgunovich
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Yazhgunovich Irina Pavlovna – Medical Physicist of the Department of Radiation  Topometry and Clinical Dosimetry.

24, Kashirskoye sh., Moscow, 115230


D. I. Fedoseenko
N.N. Blokhin Russian Research Cancer Center
Russian Federation

Fedoseenko Dmitry Igorevich – Clinical  Resident  of  the  Department  of  Radiation   Therapy, N.N.  Blokhin Russian Research Cancer Center.

24, Kashirskoye sh., Moscow, 115230


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Review

For citations:

Tkachev S.I., Patyutko Yu.I., Medvedev S.V., Romanov D.S., Sagaydak I.V., Zaspa O.A., Bykova Yu.B., Gerasimov Yu.A., Podluzhny D.V., Gakhramanov А.D., Polyakov A.N., Yurieva T.V., Gutnik R.A., Mikhailova A.V., Yazhgunovich I.P., Fedoseenko D.I. THE EFFICIENCY OF STEREOTAXIC RADIOTHERAPY IN PATIENTS WITH LIVER METASTASES. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2016;21(1):38-43. (In Russ.) https://doi.org/10.16931/1995-5464.2016138-43

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ISSN 1995-5464 (Print)
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