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Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery

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Role of Endoscopy in the Treatment of Portal Hypertension Patients

https://doi.org/10.16931/1995-5464.2015220-30

Abstract

Aim. To improve the results of treatment of patients with portal hypertension and bleeding from esophageal and gastric varices by improving diagnostic and treatment tactics.
Material and Methods. It was analyzed the results of treatment of 440 patients with esophageal and gastric varices. In 367 patients portal hypertension was caused by liver cirrhosis and in 73 patients – by extrahepatic portal block. Endoscopic ligation (EL) of esophageal veins is made in 114 patients, sclerotherapy – in 196 patients, endoscopic ligation of stomach veins type I – in 62 cases, sclerotherapy for stomach varices type II – in 44 patients. Splenectomy was performed in 23 patients with isolated varicose veins of the stomach fundus.
Results. Sclerotherapy is the most effective method to stop ongoing bleeding from esophageal and gastric varices among other endoscopic interventions. Delayed endoscopic ligation and sclerotherapy after primary hemostasis by tip-obturator improve the performance of techniques’ application and increase resistant hemostatic effect of sclerotherapy in esophagus from 58.3% to 72.1%, in stomach – from 30.0% to 77.8%; ligation in esophagus from 60.0% to 91.7% and in stomach was 92.9%. In the prevention of recurrent bleeding from esophageal and gastric varices routinely hemostatic effects of sclerotherapy in esophagus was 93.9%, in stomach – 100%; ligation in esophagus – 84.5%, in stomach –
91.7%. Features of the ES in the primary prevention of bleeding from varices limited to the large size of varices and development trophic complications. Endoscopic ligation has advantages in the prevention of first bleeding in esophagus and in stomach. In patients with isolated varices of the gastric fundus preferential treatment is splenectomy. Survival rate and hemostatic effect up to 3 years was 100%.

Conclusion. Presented data indicate the need for detailed diagnosis to make decision about possible endoscopic interventions for different types of varicose veins

About the Authors

A. G. Shertsinger
Department of Emergency Surgery and Portal Hypertension of Federal State Scientific Institution Acad. B.V. Petrovskiy Russian Research Surgery Center
Russian Federation

Doct. of Med. Sci., Professor, Head of the Department of Emergency Surgery and Portal Hypertension of Federal State Scientific Institution Acad. B.V. Petrovskiy Russian Research Surgery Center



S. B. Zhigalova
Department of Emergency Surgery and Portal Hypertension of Federal State Scientific Institution Acad. B.V. Petrovskiy Russian Research Surgery Center
Russian Federation

Doct. of Med. Sci., Leading Researcher at the Department of Emergency Surgery and Portal Hypertension of Federal State Scientific Institution Acad. B.V. Petrovskiy Russian Research Surgery Center



T. S. Semenova
Department of Emergency Surgery and Portal Hypertension of Federal State Scientific Institution Acad. B.V. Petrovskiy Russian Research Surgery Center
Russian Federation

Postgraduate of the Department of Emergency Surgery and Portal Hypertension Federal State Scientific Institution Acad.
B.V. Petrovskiy Russian Research Surgery Center



R. A. Martirosyan
Department of Emergency Surgery and Portal Hypertension of Federal State Scientific Institution Acad. B.V. Petrovskiy Russian Research Surgery Center
Russian Federation

Postgraduate of the Department of Emergency Surgery and Portal Hypertension of Federal State Scientific Institution Acad. B.V. Petrovskiy Russian Research Surgery Center



References

1. Al-Sabunchi O.M. Obosnovanie principov maloinvazivnoj hirurgii v lechenii krovotechenij iz varikozno rasshirennyh ven pishhevoda [Substantiation of principles of minimally invasive surgery in treatment of bleeding from esophageal varices: author. dis. ... doct. med. sci.]. Moscow, 2007. 46 р. (In Russian)

2. Borisov A.E., Kashchenko V.A., Raspereza D.V., Sergeev P.V. Analysis of the results of treatment of patients with acute bleeding in St. Petersburg. The role of endoscopic technologies. Rossijskij zhurnal gastrojenterologii, gepatologii, koloproktologii. 2003; 13 (1): 28. (In Russian)

3. Akahoshi T., Hashizume M., Tomikava M., Kawanaka H., Yamaguchi S., Konishi K., Kinjo N., Maehara Y. Long-term results of balloon-occluded retrograde transvenous obliteration for gastric variceal bleeding and risky gastric varices: 10 year experience. Gastroenterol. Hepatol. 2008; 23 (1): 1702–1709. doi: 10.1111/j.1440-1746. PMID:18713295.

4. Bosch J., Garcia-Pagan J.C. Complications of cirrhosis. I. Portal Hypertension. J. Hepatol. 2000; 32 (1): 141–156. PMID: 10728801. 5. Maruyama H., Yokosuka O. Current management of gastric varices. JNMA. 2007; 46 (167): 143–150. PMID: 18274572.

5. Kitsenko E.A. Prjamye vmeshatel'stva na varikozno rasshirennyh venah pishhevoda i zheludka u bol'nyh s vnepechenochnoj portal'noj gipertenziej [Direct interventions on esophageal and gastric varices in patients with extrahepatic portal hypertension: dis. ... doc. med. sci.]. Moscow, 2004. 215 p. (In Russian)

6. Mansurov A.A. Takticheskie aspekty i novye tehnologii razobshhajushhih i rekonstruktivnyh shuntirujushhih operacij u bol'nyh s portal'noj gipertenziej [Tactical aspects and new technologies of uncoupling and reconstructive bypass surgeries in patients with portal hypertension: dis. ... doc. med. sci.]. Tashkent, 2004. P. 10–12. (In Russian)

7. Angelich G.A. Diagnostika i hirurgicheskoe lechenie oslozhnenij cirroza pecheni [Diagnosis and surgical treatment of liver cirrhosis complications: dis. ... doc. med. sci]. Chisinau, 2008. Р. 15–20. (In Russian)

8. Abraldes J.G., Dell'Era A., Bosch J. Medical management of variceal bleeding in patients with cirrhosis. Can. J. Gastroenterol. 2004; 18 (2): 109–113. PMID: 14997222.

9. De Franchis R. Revising consensus in portal hypertension: Report of the Baveno V consensus workshop in methodology of diagnosis and therapy in portal hypertension. J. Hepatol. 2010; 53 (4): 762–768. DOI: doi: 10.1016/j.jhep.2010.06.004. PMID: 20638742.

10. Lubel J.S., Angus P.W. Modern management of portal hypertension. Intern. Med. J. 2005; 35 (1): 45–49. PMID: 15667468.

11. Japanese Research Society for Portal Hypertension. The general rules for recording endoscopic findings of esophageal varice. Jpn. J. Surg. 1980; 10 (3): 84–87. PMID: 2753992.

12. Sarin S.K., Agarwal S.R. Gastric varices and portal hypertensive gastropathy. Clinic. Liver Disease. 2001; 5 (3): 3–20. PMID: 11565139.

13. Lebezev V.M. Portokaval'noe shuntirovanie u bol'nyh s portal'noj gipertenziej [Portocaval shunting in patients with portal hypertension: dis. ... doc. med. sci]. Moscow, 1994. 44 p. (In Russian)

14. Shertsinger A.G., Zhigalova S.B., Musin R.A. Experience of esophageal varices endoscopic ligation in patients with portal hypertension. Annaly khirurgicheskoj gepatologii. 2005; 10 (2): 94. (In Russian)

15. De Franchis R., Primignani M. Endoscopic treatments for portal hypertension. Seminars Liver Disease. 1999; 19 (4): 439–455. PMID: 10643628.

16. Vianna A., Hayes P.C., Moscoso G., Driver M., Portmann B., Westaby D., Williams R. Normal venous circulation of the gastroesophageal junction. A route to understanding varices. Gastroenterology. 1987; 93 (4): 876. PMID: 3623028.

17. Chikamori F., Kuniyoshi N., Shibuya S., Takase Y. Correlation between endoscopic and angiographic findings in patients with esophageal and isolated gastric varices. @Dig. Surg@. 2001; 18 (3): 176–181. PMID: 11464006.

18. Manuk’jan V.G. Vybor metoda operacii azigo-portal'nogo razobshhenija u bol'nyh cirrozom pecheni i portal'noj gipertenziej [The choice of azigo-portal dissociation technique in patients with cirrhosis and portal hypertension: dis. ... cand. med. sci.]. Moscow, 2011. 24 p. (In Russian)

19. Sarin S.K., Lahoti D., Saxena S.P., Murthy N.S., Makwana U.K. Prevalence, classification and natural history of gastric varices. A long-term follow-up study in 568 portal hypertension patients. Hepatology. 1992; 16 (6): 1343–1349. PMID: 1446890.

20. Paquet K.-J. Endoscopic paravariceal injection sclerotherapy of the esophagus indications, technique, complications, results of a period of nearly 14 years. Gastrointest. Endosc. 1983; 29 (4): 310–337. PMID: 6605897.

21. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. N. Engl. J. Med. 1988; 319 (15): 983–989. PMID: 3262200.

22. Manuk’jan G.V. Patogenez, lechenie i profilaktika oslozhnenij v hirurgii portal'noj gipertenzii u bol'nyh cirrozom pecheni [Pathogenesis, treatment and prevention of complications in portal hypertension surgery in patients with liver cirrhosis: dis. ... doc. med. sci.]. Moscow, 2003. P. 3–45. (In Russian)

23. Gamidov A.B. Rol' neparnoj veny v patogeneze krovotechenij iz varikoznyh ven pishhevoda i zheludka u bol'nyh s dekompensirovannym cirrozom pecheni [The role of azygos vein in pathogenesis of bleeding from esophageal and gastric varices in patients with decompensated liver cirrhosis: dis. ... cand. med. sci.]. Moscow, 2008. P. 11–26. (In Russian)


Review

For citations:


Shertsinger A.G., Zhigalova S.B., Semenova T.S., Martirosyan R.A. Role of Endoscopy in the Treatment of Portal Hypertension Patients. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2015;20(2):20-30. (In Russ.) https://doi.org/10.16931/1995-5464.2015220-30

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ISSN 1995-5464 (Print)
ISSN 2408-9524 (Online)