Hepatic Encephalopathy in Patients with Liver Cirrhosis before and after TIPS
https://doi.org/10.16931/1995-5464.2015240-45
Abstract
Aim. To analyze the dynamics of hepatic encephalopathy after transjugular intrahepatic portosystemic shunting (TIPS).
Material and Methods. It was analyzed the results of complex survey of 52 patients who underwent TIPS. Self-expanding stents 8–10 cm, diameter of 8–10 mm and stent-graft were applied for portosystemic shunt creation.
Results. The two main complications of TIPS are hepatic encephalopathy progression and shunt’s malfunction. The
increased degree of portosystemic encephalopathy in 18 months postoperatively was revealed in 3 (10%) patients. Symptoms of encephalopathy were eliminated and did not effect on the patients’ life quality after discharge.
Conclusion. Assessment of encephalopathy’s degree and individual therapy in each patient significantly decrease the severity of encephalopathy postoperatively followed by improved life quality
About the Authors
I. I. ZatevakhinRussian Federation
Doct. of Med. Sci., Professor, Academican of Russian Academy of Sciences, Head of the Department of Surgical Diseases, Faculty of Pediatrics, N.I. Pirogov Russian National Research Medical University
M. Sh. Tsitsiashvili
Russian Federation
Doct. of Med. Sci., Professor of the Department of Surgical Diseases, Faculty of Pediatrics, N.I. Pirogov Russian National Research Medical University
V. N. Shipovskiy
Russian Federation
Doct. of Med. Sci., Professor of the Department of Surgical Diseases, Faculty of Pediatrics, N.I. Pirogov Russian National Research Medical University
D. V. Monakhov
Russian Federation
Cand. of Med. Sci., Associate Professor of the Department of Surgical Diseases, Faculty of Pediatrics, N.I. Pirogov Russian National Research Medical University
A. V. Pan
Russian Federation
Cand. of Med. Sci., Resident of City Clinical Hostipal № 57
References
1. Jalan R., Elton R.A., Redhead D.N., Finlayson N.D., Hayes P.C. Analysis of prognostic variables in the prediction of mortality, shunt failure, variceal rebleeding and encephalopathy following the transjugular intrahepatic portosystemic stent-shunt for variceal haemorrhage. J. Hepatol. 1995; 23 (2): 123–128.
2. Шерлок Ш., Дули Дж. Заболевания печени и желчевыводящих путей: Практическое руководство. Пер. с англ. Под ред. З.Г. Апросиной, Н.А. Мухина. М.: ГЭОТАР-медицина, 1999. 864 с. Sherlok Sh., Duli Dzh. Zabolevaniya pecheni i zhelchnykh putey: prakticheskoe rukovodstvo [Liver and biliary tract diseases: a practical guide]. Moscow: GEOTAR-Meditsina, 1999. 864 p. (In Russian)
3. Grosso M., Gerd N., Fava C. Transjugular Intrahepatic Portosystemic Shunt: indication, technique and results. Gnocchi, 1998. 153 p.
4. Rees C.J., Oppong K., Mardin H.Al., Hudson M., Record C.O. Effect of L-ornithin-L-aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. GUT. 2000; 47 (11): 571–574.
5. Somberg K.A., Riegler J.L., LaBerge J.M., Doherty-Simor M.M., Bachetti P., Roberts J.P., Lake J.R. Hepatic encephalopathy after transjugular intrahepatic portosystemic shunts: incidence and risk factors. Am. J. Gastroenterol. 1995; 90 (1): 549–555.
6. Sanyal A.J., Freedman A.M., Shiffman M.L., Purdum P.P. III, Luketic V.A., Cheatham A.K. Portosystemic encephalopathy after transjugular intrahepatic portosystemic shunt: results of a prospective controlled study. Hepatology. 1994; 20 (11): 46–55.
7. Reynolds N., Downie S., Smith K., Kircheis G., Rennie M.I. Treatment with L-ornithine-L-aspartate infusion restores muscle protein synthesis responsiveness to feeding in patients with cirrhosis. J. Hepatol. 1999; 30 (Suppl. 1): abstract.
8. Пациора М.Д. Хирургия портальной гипертензии. 2-е изд., доп. М.: Медицина, 1974. 407. Paciora M.D. Khirurgiya portal'noj gipertenzii [Surgery of portal hypertension]. Second edition. Moscow: Medicine, 1974. 407 p. (In Russian)
9. Jalan R., Hayes P.C. Hepatic encephalopathy and ascites. Lancet. 1997; 350 (12): 1309–1315.
10. Kerlan R.K., La Berge J.M., Gordon R.L., Ring E.J. Transjugular intrahepatic portosystemic shunts: current status. Am. J. Roentgenol. 1995; 164 (5): 1059–1066.
11. La Berge J.M., Ring E.J., Gordon R.L., Lake J.R., Doherty M.M., Somberg K.A., Roberts J.P., Ascher N.L. Creation of transjugular intrahepatic portosystemic shunts with the wallstent endoprosthesis: results in 100 patients. Radiology. 1993; 187 (2): 413–420.
12. Helton W.S., Belshaw A., Althaus S., Park S., Coldwell D., Johansen K. Critical appraisal of the angiographic portacaval shunt (TIPS). Am. J. Surg. 1993; 165 (5): 566–571.
13. Martin M., Zajko A.B., Orons P.D., Dodd G., Wright H., Colangelo J., Tartar R. Transjugular intrahepatic portosystemic shunt in the management of variceal bleeding: indications and clinical results. Surgery. 1993; 114 (4): 719–726. 14. Rossle M. When endoscopic therapy or pharmacotherapy fails to control variceal bleeding: what should be done? Immediate control of bleeding by TIPS? Langenbecks Arch. Surg. 2003; 388 (3): 155–162.
14. Zuckerman D.A., Darcy M.D., Bocchini T.P., Hildebolt C.F. Enchephalopathy after transjugular intrahepatic portosystemic shunting: analysis and incidence of potential risk factors. AJR. 1997; 169 (6): 1727–1731.
15. Jalan R., Forrest E.H., Stanley A.J., Redhead D.N., Forbes J., Dillon J.F., MacGilchrist A.J., Finlayson N.D., Hayes P.C. A randomized trial comparing transjugular intrahepatic portosystemic stent-shunt with variceal band ligation in the prevention of rebleeding from esophageal varices. Hepatology. 1997; 26 (5): 1115–1122.
Review
For citations:
Zatevakhin I.I., Tsitsiashvili M.Sh., Shipovskiy V.N., Monakhov D.V., Pan A.V. Hepatic Encephalopathy in Patients with Liver Cirrhosis before and after TIPS. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2015;20(2):40-45. (In Russ.) https://doi.org/10.16931/1995-5464.2015240-45