Comparative Analysis of ”Nonequilibrium Plasma” and Cryodestruction in Surgery of Chronic Liver Abscesses in the Experiment

Aim. To compare the effects of “nonequilibrium plasma” and cryodestruction on liver abscesses in experiment.

Material and Methods. 60 experimental animals (rats, males) with liver abscess were enrolled. There were 3 groups by 20 animals.  Placebo group – abscess cavity lavage with sterile 0.9% NaCl  solution, control group – cryodestruction of abscess wall (liquid  nitrogen, temperature of −196 °C), experimental group – abscess  wall management with “nonequilibrium plasma”. Animals were  eliminated from the experiment in 1, 5, 15 and 30 days after  surgery. We examined bacterial inoculation of the abscess cavity  after exposure, performed biopsy of abscess wall and surrounding liver parenchyma specimens and biochemical analysis of blood.

Results. Bacterial growth in abscess cavity was absent in control and experimental groups. Biochemical analysis revealed only  insignificant fluctuations of the majority of indicators in all groups.  There were less significant inflammatory infiltration and edema of  the abscess capsule, as well as inflammatory infiltration of liver  parenchyma in 5 and 15 days in experimental vs. control group.

Conclusion. Cryodestruction and effect of “nonequilibrium plasma” on the internal wall of rats’ liver abscess lead to death of pyogenic  bacteria. “Nonequilibrium plasma” is associated with less severe  injury of liver parenchyma compared with cryodestruction.

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