RESULTS OF ADEMETHIONIN ADMINISTRATION AFTER EXTENSIVE LIVER RESECTIONS
https://doi.org/10.16931/1995-5464.2017364-69
Abstract
Aim. To study adamethionin effect on liver failure course after extensive liver resection.
Material and Methods. 538 patients after extensive liver resection were included into study. Adamethionin has been used in the main group (326 patients) postoperatively while in the control group (212 patients) hepatoprotective therapy was absent. Incidence and severity of liver failure as well as postoperative complications were analyzed.
Results. Total incidence of post-resection liver failure was 23% (18.7% and 30.2% in the main and control groups respectively, p < 0.05). Mild complications were predominant in the main group while moderate and severe events were observed in the control groups. Post-resection liver failure by “50–50 criteria” was revealed in 27 patients of the control group (12.7%) vs. 13 patients of the main group (4.0%) (p < 0.05). There was significant decrease of ALT and AST activity in the main group compared with the control group postoperatively. Overall incidence of postoperative complications was 18.9% and 17.2% in control and main groups respectively. The incidence of biliary complications was 7.5% and 6.4% in both groups respectively (p > 0.05). Postoperative hospital-stay was 15 (12–28) days in the control group and 11 (9–19) days in the main group (p < 0.05).
Conclusion. Liver failure is possible after extensive liver resections (over three segments). Ademetionin contributes to restoration of liver structure and function, reduces the incidence of liver failure and hospital-stay, provides faster recovery of residual liver parenchyma.
About the Authors
S. E. Voskanyan
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Voskanyan Sergey Eduardovich – Doct. of Med. Sci., Deputy Chief Physician for Surgical Care, Head of Surgery and Transplantation Center, Head of the Department of Surgery with the Courses of Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology and Organ Donation of the Institute of Postgraduate Professional Education, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
Russian Federation
Voskanyan Sergey Eduardovich – Doct. of Med. Sci., Deputy Chief Physician for Surgical Care, Head of Surgery and Transplantation Center, Head of the Department of Surgery with the Courses of Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology and Organ Donation of the Institute of Postgraduate Professional Education, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
M. V. Zabelin
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Zabelin Maksim Vasil'evich – Doct. of Med. Sci., Deputy General Director, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
Russian Federation
Zabelin Maksim Vasil'evich – Doct. of Med. Sci., Deputy General Director, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
E. V. Naydenov
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Russian Federation
Naydenov Evgeny Vladimirovich – Cand. of Med. Sci., Surgeon of the Surgical Department, Senior Researcher of the Laboratory of the New Surgical Technologies, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
For correspondence: 23, Marshal Novikov str., Moscow, 123098, Russian Federation. Phone: +7-499-190-95-61. E-mail: e.v.naydenov@mail.ru
A. I. Artem’yev
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Artem’yev Alexey Igorevich – Cand. of Med. Sci., Head of the Surgical Department, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
Russian Federation
Artem’yev Alexey Igorevich – Cand. of Med. Sci., Head of the Surgical Department, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
D. A. Zabezhinsky
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Zabezhinsky Dmitry Alexandrovich – Cand. of Med. Sci., Surgeon of the Surgical Department, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
Russian Federation
Zabezhinsky Dmitry Alexandrovich – Cand. of Med. Sci., Surgeon of the Surgical Department, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
I. Yu. Kolyshev
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Kolyshev Ilya Yurievich – Cand. of Med. Sci., Surgeon of the Surgical Department, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
Russian Federation
Kolyshev Ilya Yurievich – Cand. of Med. Sci., Surgeon of the Surgical Department, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
V. S. Rudakov
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Rudakov Vladimir Sergeevich – Surgeon of the Coordination Center of Organs and (or) Human Tissues, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
Russian Federation
Rudakov Vladimir Sergeevich – Surgeon of the Coordination Center of Organs and (or) Human Tissues, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
M. V. Shabalin
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Shabalin Maxim Vyacheslavovich – Surgeon of the Surgical Department, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
Russian Federation
Shabalin Maxim Vyacheslavovich – Surgeon of the Surgical Department, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
A. S. Zhurbin
State Research Center of the Russian Federation – Burnazyan Federal Medical Biophysical Center of the Federal Medical Biological Agency.
Russian Federation
Zhurbin Alexey Sergeevich – Postgraduate Student, Department of Surgery with the Courses of Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology and Organ Donation of the Institute of Postgraduate Professional Education, Junior Researcher of the Laboratory of the New Surgical Technologies, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
Russian Federation
Zhurbin Alexey Sergeevich – Postgraduate Student, Department of Surgery with the Courses of Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology and Organ Donation of the Institute of Postgraduate Professional Education, Junior Researcher of the Laboratory of the New Surgical Technologies, Surgery and Transplantation Center, Burnazyan Federal Medical Biophysical Center of FMBA of Russia.
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For citations:
Voskanyan S.E., Zabelin M.V., Naydenov E.V., Artem’yev A.I., Zabezhinsky D.A., Kolyshev I.Yu., Rudakov V.S., Shabalin M.V., Zhurbin A.S. RESULTS OF ADEMETHIONIN ADMINISTRATION AFTER EXTENSIVE LIVER RESECTIONS. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2017;22(3):64-69. (In Russ.) https://doi.org/10.16931/1995-5464.2017364-69
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