Repeat hepatectomy in patients with colorectal liver metastases
https://doi.org/10.16931/1995-5464.2019456-64
Abstract
Aim. To improve the results of treatment recurrent colorectal liver metastases after liver resection with its isolated lesion.
Materials and methods. The results of repeated surgical treatment of recurrent colorectal liver metastases in 78 patients were analyzed. Postoperative complications frequency and blood loss was similar during primary and repeated resections. The five-year survival rate after repeated liver resection with reccurens of colorectal cancer liver metastases was 49 ± 9%.
Results. Multivariate analysis revealed 3 predictors of the favorable prognosis of liver resection: removal of all extrahepatic metastases at the repeated resection, radicality of the repeated procedure, chemotherapy after repeated resection.
Conclusion. Long-term results of the repeated surgical treatment of recurrent colorectal liver metastases recognize the feasibility of repeated liver resection in a separate category of patients. The treatment strategy for colorectal cancer liver metastases requires a combined multidisciplinary approach. This approach may include methods of local, regional or systemic antitumor effects in addition to resection, if indications exist.
Materials and methods. The results of repeated surgical treatment of recurrent colorectal liver metastases in 78 patients were analyzed. Postoperative complications frequency and blood loss was similar during primary and repeated resections. The five-year survival rate after repeated liver resection with reccurens of colorectal cancer liver metastases was 49 ± 9%.
Results. Multivariate analysis revealed 3 predictors of the favorable prognosis of liver resection: removal of all extrahepatic metastases at the repeated resection, radicality of the repeated procedure, chemotherapy after repeated resection.
Conclusion. Long-term results of the repeated surgical treatment of recurrent colorectal liver metastases recognize the feasibility of repeated liver resection in a separate category of patients. The treatment strategy for colorectal cancer liver metastases requires a combined multidisciplinary approach. This approach may include methods of local, regional or systemic antitumor effects in addition to resection, if indications exist.
About the Authors
Yu. I. Patyutko
Blokhin National Medical Research Center of Oncology оf the Ministry of Health of Russia
Russian Federation
Doct. of Sci. (Med.), Professor, Chief Researcher of the Department of Hepatopancreatobiliary Surgery
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
Russian Federation
Doct. of Sci. (Med.), Professor, Chief Researcher of the Department of Hepatopancreatobiliary Surgery
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
A. A. Ivanov
Blokhin National Medical Research Center of Oncology оf the Ministry of Health of Russia
Russian Federation
Cand. of Sci. (Med.), Deputy Chief Physician of Clinic “Medicina 24/7”
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
Russian Federation
Cand. of Sci. (Med.), Deputy Chief Physician of Clinic “Medicina 24/7”
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
D. V. Podluzhny
Blokhin National Medical Research Center of Oncology оf the Ministry of Health of Russia
Russian Federation
Cand. of Sci. (Med.), Head of the Department of Hepatopancreatobiliary Surgery
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of the Department of Hepatopancreatobiliary Surgery
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
A. G. Kotelnikov
Blokhin National Medical Research Center of Oncology оf the Ministry of Health of Russia
Russian Federation
Russian Federation
Doct. of Sci. (Med.), Professor, Leading Researcher of the Department of Hepatopancreatobiliary Surgery
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
A. N. Polyakov
Blokhin National Medical Research Center of Oncology оf the Ministry of Health of Russia
Russian Federation
Cand. of Sci. (Med.), Senior Researcher of the Department of Hepatopancreatobiliary Surgery
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
Russian Federation
Cand. of Sci. (Med.), Senior Researcher of the Department of Hepatopancreatobiliary Surgery
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
M. M. Magomedov
Blokhin National Medical Research Center of Oncology оf the Ministry of Health of Russia
Russian Federation
Graduate Student of the Department of Hepatopancreatobiliary Surgery
Phone: +7-968-014-33-12
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
Russian Federation
Graduate Student of the Department of Hepatopancreatobiliary Surgery
Phone: +7-968-014-33-12
23, Kashirskoe shosse, Moscow, 115478, Russian Federation
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Review
For citations:
Patyutko Yu.I., Ivanov A.A., Podluzhny D.V., Kotelnikov A.G., Polyakov A.N., Magomedov M.M. Repeat hepatectomy in patients with colorectal liver metastases. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2019;24(4):56-64. (In Russ.) https://doi.org/10.16931/1995-5464.2019456-64
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