Liver transplantation for metastases from neuroendocrine tumors: a literature review and clinical observation
S. E. Voskanyan,
A. I. Artemiev,
E. V. Naidenov,
D. A. Zabezhinsky,
M. V. Shabalin,
M. V. Popov,
A. N. Bashkov,
K. K. Gubarev,
V. S. Rudakov,
E. V. Vidmer,
A. S. Zhurbin https://doi.org/10.16931/1995-5464.2022-3-33-45
Abstract
Neuroendocrine tumors are a rare and heterogeneous group of neoplasms with different malignant potential. They often metastasize to the liver and require active combined therapy. For unresectable neuroendocrine tumors with liver metastases, transplantation has become a potential definitive treatment due to the slow growth and the clinical course of the metastatic process. We conducted a review of relevant literature, the criteria for including and excluding patients considered for liver transplantation as well as alternative methods of treatment of neuroendocrine tumors. The paper presents a clinical observation of a staged combined therapy of a patient with a neuroendocrine tumor of the small intestine and bilobar unresectable liver metastases. The study demonstrates satisfactory long-term results of liver transplantation.
About the Authors
S. E. Voskanyan
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Sergey E. Voskanyan – Doct. of Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Deputy Chief Physician for Surgical Care, Head of the Center for Surgery and Transplantology; Head of the Department of Surgery with Courses in Surgical Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology, and Organ Donation of the Institute of Postgraduate Professional Education
23, Marshal Novikov str., Moscow, 123098, Russian Federation
A. I. Artemiev
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Alexey I. Artemiev – Cand. of Sci. (Med.), Head of Surgical Department No. 2, the Center for Surgery and Transplantation; Associate Professor, the Department of Surgery with Courses in Surgical Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology, and Organ Donation of the Institute of Postgraduate Professional Education
23, Marshal Novikov str., Moscow, 123098, Russian Federation
E. V. Naidenov
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Evgenii V. Naidenov – Cand. of Sci. (Med.), Surgeon, Surgical Department No. 2, Senior Researcher, Laboratory of New Surgical Technologies No. 50, Center for Surgery and Transplantology; Associate Professor, the Department of Surgery with Courses in Surgical Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology, and Organ Donation of the Institute of Postgraduate Professional Education
23, Marshal Novikov str., Moscow, 123098, Russian Federation
D. A. Zabezhinsky
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Dmitry A. Zabezhinsky – Cand. of Sci. (Med.), Surgeon, Surgical Department No. 2, the Center for Surgery and Transplantology
23, Marshal Novikov str., Moscow, 123098, Russian Federation
M. V. Shabalin
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Maxim V. Shabalin – Cand. of Sci. (Med.), Surgeon, Surgical Department No. 1, the Center for New Surgical Technologies
23, Marshal Novikov str., Moscow, 123098, Russian Federation
M. V. Popov
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Maxim V. Popov – Cand. of Sci. (Med.), Physician in X-ray Endovascular Diagnosis and Treatment, the Department of X-ray Surgical Methods of Diagnosis and Treatment
23, Marshal Novikov str., Moscow, 123098, Russian Federation
A. N. Bashkov
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Andrey N. Bashkov – Cand. of Sci. (Med.), Head of the Department of Radiological and Radioisotope Diagnostics
23, Marshal Novikov str., Moscow, 123098, Russian Federation
K. K. Gubarev
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Konstantin K. Gubarev – Cand. of Sci. (Med.), Head of the Surgical Department, the Center for the Coordination of Human Organ and/or Tissue Donation, Head of the ECMO Center
23, Marshal Novikov str., Moscow, 123098, Russian Federation
V. S. Rudakov
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Vladimir S. Rudakov – Cand. of Sci. (Med.), Surgeon, the Center for the Coordination of Human Organ and/or Tissue Donation, the Center for Surgery and Transplantology
23, Marshal Novikov str., Moscow, 123098, Russian Federation
E. V. Vidmer
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Elena V. Vidmer – Graduate Student, the Department of Surgery with Courses in Surgical Oncology, Endoscopy, Surgical Pathology, Clinical Transplantology, and Organ Donation, the Institute of Graduate Studies
23, Marshal Novikov str., Moscow, 123098, Russian Federation
A. S. Zhurbin
State Research Center – A.I. Burnazyan Federal Medical Biophysical Center of the FMBA of Russia
Russian Federation
Russian Federation
Alexey S. Zhurbin – Junior Researcher, Laboratory of New Surgical Technologies No. 50, the Center for Surgery and Transplantology
23, Marshal Novikov str., Moscow, 123098, Russian Federation
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For citations:
Voskanyan S.E., Artemiev A.I., Naidenov E.V., Zabezhinsky D.A., Shabalin M.V., Popov M.V., Bashkov A.N., Gubarev K.K., Rudakov V.S., Vidmer E.V., Zhurbin A.S. Liver transplantation for metastases from neuroendocrine tumors: a literature review and clinical observation. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2022;27(3):33-45. (In Russ.) https://doi.org/10.16931/1995-5464.2022-3-33-45
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