Antioxidant effect of negative air ions in correction of hepatic dysfunction in mechanical jaundice

Aim. To evaluate the effectiveness of negative air ions in eliminating hepatic dysfunction in mechanical jaundice.  

Materials and methods. Experiments on 30 rats were carried out in two series. In the first experiment series, the mechanical jaundice was simulated with subsequent decompression of common bile duct and injection of 0.9% sodium chloride solution in the volume of 40 ml/kg. In the second experimental series, negative air ions (3 mln particles per 1 cm3 ) were exposed for 60 min once a day over the course of 12 days. The levels of bilirubin, malondialdehyde, ALT and AST, alkaline phosphatase and catalase were studied.  

Results. The use of negative air ions in mechanical jaundice contributed to significant correction of the liver functional activity. Concentration of total and direct bilirubin decreased to 84.4 ± 7.6 and 42.1 ± 5.4 μmol/l, which is 25% and 56% lower than in the control series. The activity of AST, ALT, and alkaline phosphatase, as well as the concentration of malondialdehyde were reported to be lower in than control series (by 17%, 22%, 18%, 47%, correspondingly), while the catalase activity was 3.6 times higher.  

Conclusion. Application of negative air ions in treatment of mechanical jaundice stimulates production of own antioxidative enzymes which protect hepatocytes from free radical damage. 

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