The Use of Adhesive Coating for Pancreatic Surgery
https://doi.org/10.16931/1995-5464.2017439-45
Abstract
Aim. To determine the most active hemostatic agent in pancreatic surgery and the possibility of plastic closure of pancreatic duct system.
Material and Methods. The experiment was performed on 12 mongrel dogs. Comparative analysis of haemostatic capabilities of the drugs “Hemostatic collagen sponge” (Russia), “Tabotamp-Surgicel” (USA), “Gelaspon” (Germany) and fibrin-collagen substance “Tachocomb” (Austria) was performed in an acute experiment with model of distal pancreatectomy. There were 6 animals. In a chronic experiment (6 animals) we examined the possibility of plastic closure of the pancreatic duct system after distal resection and morphological processes occurring in the fibrin-collagen substance application zone after 7 and 14 days. In clinical conditions fibrin-collagen substance was used to stop bleeding
from pancreatic tissue in 49 cases.
Results. Acute experiment data has shown more effective stopping of bleeding from pancreatic tissue after proximal resection due to FCC application. Other haemostatic drugs (hemostatic collagen sponge, gelaspon, tabotamp) showed less pronounced effect. In chronic experiment the possibility of pancreatic duct system sealing with two plates of fibrincollagen substance without prior ligation or suturing was indicated. Morphological investigation revealed stimulation of angiogenesis and fibroblastic reaction. Hemostatic biopolymer fibrin-collagen substance was successfully used in 49 patients for pancreatic procedures.
Conclusion. Fibrin-collagen substance is the most effective hemostatic agent. Clinical use of this agent confirmed experimental data about high hemostatic efficacy of the drug.
About the Authors
V. A. Gorskiy
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Gorskiy Victor Aleksandrovich – Doct. of Med. Sci., Professor, Head of the Department of Experimental and Clinical Surgery, Medical Biological Faculty, Pirogov Russian National Research Medical University.
1, Ostrovityanova str., Moscow, 117997, Russian Federation
А. P. Ettinger
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Ettinger Alexander Pavlovich – Doct. of Med. Sci., Professor, Head of the Department of Biomedical Research Organization, Medical Biological Faculty, Pirogov Russian National Research Medical University.
1, Ostrovityanova str., Moscow, 117997, Russian Federation
A. V. Volenko
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
Volenko Alexander Vladimirovich – Doct. of Med. Sci., Professor of the Department of Urgent and General Surgery of the Russian Medical Academy of Postgraduate Education.
2/1, C. 1, Barrikadnaya str., Moscow, 123242, Russian Federation
А. P. Faller
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Faller Alexander Petrovich – Doct. of Med. Sci., Professor of the Department of Experimental and Clinical Surgery, Medical Biological Faculty, Pirogov Russian National Research Medical University.
1, Ostrovityanova str., Moscow, 117997, Russian Federation
M. D. Polivoda
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Polivoda Mikhail Dmitrievich – Cand. of Med. Sci., Associate Professor of the Department of Experimental and Clinical Surgery, Medical Biological Faculty, Pirogov Russian National Research Medical University.
1, Ostrovityanova str., Moscow, 117997, Russian Federation
V. P. Armashov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Armashov Vadim Petrovich – Cand. of Med. Sci., Associate Professor of the Department of Experimental and Clinical Surgery, Medical Biological Faculty, Pirogov Russian National Research Medical University.
1, Ostrovityanova str., Moscow, 117997, Russian Federation
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Review
For citations:
Gorskiy V.A., Ettinger А.P., Volenko A.V., Faller А.P., Polivoda M.D., Armashov V.P. The Use of Adhesive Coating for Pancreatic Surgery. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2017;22(4):39-45. (In Russ.) https://doi.org/10.16931/1995-5464.2017439-45
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