PRIMARY PREVENTION OF BLEEDING FROM ESOPHAGEAL AND GASTRIC VARICES IN PATIENTS WITH PORTAL HYPERTENSION
https://doi.org/10.16931/1995-5464.2016293-104
Abstract
The problem of primary prevention of bleeding from esophageal and gastric varices in patients with portal hypertension is discussed in the review. It was analyzed main views on the mechanisms of bleeding whose study is important to define pathogenetic primary prevention. The role of accurate diagnosis of the esophageal and gastric varices state is presented to predict the risk of bleeding. It was reviewed the variants of primary prevention of bleeding using medical, endoscopic, surgical and X-ray endovascular techniques. Also different drugs for primary prevention of bleeding were characterized depending on main disease nature and degree of compensation. Minimally invasive methods for primary prevention including endoscopic, endovascular techniques and medical therapy were compared. The authors discuss some unsolved problems of primary prevention of bleeding in patients with intrahepatic and extrahepatic portal hypertension, as well as in primary distribution of varices in stomach.
About the Authors
G. V. Manukyan
B.V. Petrovsky Russian Research Center of Surgery.
Russian Federation
Manuk'yan Garik Vaganovich — Doct. of Med. Sci., Head of the Department of Emergency Surgery and Portal Hypertension
Russian Federation
Manuk'yan Garik Vaganovich — Doct. of Med. Sci., Head of the Department of Emergency Surgery and Portal Hypertension
A. G. Shertsinger
B.V. Petrovsky Russian Research Center of Surgery.
Russian Federation
Shertsinger Alexander Georgievich — Doct. of Med. Sci., Professor, Senior Researcher of the Department of Emergency Surgery and Portal Hypertension
Russian Federation
Shertsinger Alexander Georgievich — Doct. of Med. Sci., Professor, Senior Researcher of the Department of Emergency Surgery and Portal Hypertension
S. V. Zhigalova
B.V. Petrovsky Russian Research Center of Surgery.
Russian Federation
Russian Federation
Zhigalova Svetlana Borisovna — Doct. of Med. Sci., Senior Researcher of the Department of Emergency Surgery and Portal Hypertension
For correspondence: Zhigalova Svetlana Borisovna — Apt. 38, building 1, d.33, Zhulebinsky Boulevard, Moscow, 109431, Russian Federation
T. S. Semenova
B.V. Petrovsky Russian Research Center of Surgery.
Russian Federation
Semenova Tatyana Semenovna — Cand. of Med. Sci., Researcher of the Department of Emergency Surgery and Portal Hypertension
Russian Federation
Semenova Tatyana Semenovna — Cand. of Med. Sci., Researcher of the Department of Emergency Surgery and Portal Hypertension
R. A. Martirosyan
B.V. Petrovsky Russian Research Center of Surgery.
Russian Federation
Martirosyan Rosa Armenovna — Postgraduate of the Department of Emergency Surgery and Portal Hypertension
Russian Federation
Martirosyan Rosa Armenovna — Postgraduate of the Department of Emergency Surgery and Portal Hypertension
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For citations:
Manukyan G.V., Shertsinger A.G., Zhigalova S.V., Semenova T.S., Martirosyan R.A. PRIMARY PREVENTION OF BLEEDING FROM ESOPHAGEAL AND GASTRIC VARICES IN PATIENTS WITH PORTAL HYPERTENSION. Annaly khirurgicheskoy gepatologii = Annals of HPB Surgery. 2016;21(2):93-104. (In Russ.) https://doi.org/10.16931/1995-5464.2016293-104
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